The relationship between serum malondialdehyde levels and severity of acne vulgaris on male

Abstract

Acne vulgaris is a multifactorial disorder characterized by seborrhea, microcomedones, comedones,
papules, pustules, nodules and possibly scarring. The pathogenesis of acne is not completely
understood. Recent studies reported the possible role of reactive oxygen spesies (ROS) especially
lipid peroxides in mediating acne inflammation. Malondialdehyde (MDA) is one of the final products
of the lipid peroxidation that commonly used as a lipid peroxidation marker. This study was conducted
to evaluate the correlation between serum MDA levels and severity of acne on male patients. A total
60 patients with acne who attended in Polyclinic of Department of Dermatology and Venereology,
Dr Sardjito General Hospital and met the inclusion and exclusion were involved in the study. The
patients were then classified using combined acne severity classification method into three group as
mild, modrate and severe acnes. Blood sample were then taken from all subjects and serum MDA
levels were determined spectrophotometer. The mean serum MDA levels of severe acne group
(1.85 ± 0.368 μmol/L) were significantly higher than that moderate acne group (0.79 ± 0.159
μmol/L) (p = 0.000) and that mild acne group (0.52 ± 0.239 μmol/L) (p = 0.000). Moreover, the
mean MDA levels of moderate acne group were also significantly higher than that mild acne group
(p = 0.002). Significantly positive correlation was observed between serum MDA levels and acne
lesions total count (r = 0.714; p = 0.000). It can be concluded, there is positive relationship
between serum MDA levels and severity of acne vulgaris on male patients.