Antimicrobial activity of bioactive compounds isolated from Swietenia mahagoni (L) Jacq. against Staphylococcus aureus and Pseudomonas aeruginosa
https://doi.org/10.19106/JMedScie004604201402
Handry Darussalam,
(1*) , Titik Nuryastuti
(2) , . Mursiti
(3) , . Mustofa
(4)
(1) Health Polytechnic of East Kalimantan, Minitry of Health,
(2) Department of Microbiology, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta,
(3) Department of Chesmistry, Universitas Negeri Semarang, Semarang,
(4) Department of Pharmacology and Therapy, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia
(*) Corresponding Author
Abstract
Widespread bacterial resistance has led to more difficult to treat infectious diseases with available antibiotics. Therefore, new antibiotics are needed face of the growing antibiotic resistance. Swietenia mahagoni (L.) Jacq. is one of potential medicinal plants as a source new antibiotics. Five compounds have been isolated from an ethanolic extract of S. mahagoni (L.) Jacq., however its antimicrobial activity has not been investigated, yet. This study was conducted to evaluate the antimicrobial activity of these compounds. Minimal Inhibitory Concentration (MIC) and Minimal Bactericidal Concentration (MBC) were determined against Staphylococcus aureus and Pseudomonas aeruginosa strains. Among five compounds tested, compound 3 (3,4,5,6,7-pentaethyl-1-methoxy-1H-indazole) and compound 4 (5-ethyl-6-methoxymethyl-2-methyl-1,2-dihydropyridine) were found to be active against the bactrial strains tested with the MICs and MBCs values ranged from 50 to 100 μg/mL. In conclusion, among five compounds isolated from S. mahagoni (L.) Jacq., compound 3 and 4 showed moderate antimicrobial activity against S. aureus and P. aeruginosa strains.
Keywords
Swietenia mahogany – active compounds – antimicrobial activity - Staphylococcus aureus - Pseudomonas aeruginosa
DOI:
https://doi.org/10.19106/JMedScie004604201402
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