Resistin associated with higher cardiovascular events in intermediate grace score of acute coronary syndrome

https://doi.org/10.19106/JMedSci005303202105

Rizki Amalia Gumilang(1*), Nahar Taufiq(2), Budi Yuli Setianto(3)

(1) Academic Hospital, Universitas Gadjah Mada/ Department of Cardiology and Vascular Medicine, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr. Sardjito General Hospital, Yogyakarta
(2) Department of Cardiology and Vascular Medicine, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr. Sardjito General Hospital, Yogyakarta
(3) Department of Cardiology and Vascular Medicine, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr. Sardjito General Hospital, Yogyakarta
(*) Corresponding Author

Abstract


Previous studies revealed that inflammatory biomarkers have a role in the
clinical outcomes of acute coronary syndromes (ACS) and also in prediction
of cardiovascular events using GRACE score. Resistin, a recently identified
inflammatory biomarker, also has a role in clinical outcomes of ACS but
its role related to GRACE score risk stratification is unknown. Three risk
stratifications of ACS based on GRACE scores were used i.e. low, intermediate,
and high.  Some studies reported that inflammatory biomarkers have a role
in cardiovascular events of patients with low risk GRACE scores, but their role
in the patients with intermediate risk still needs to be elucidated. This study
aimed to investigate the role of resistin in cardiovascular events of ACS patients
with intermediate risk GRACE score. This was an observational study using a
cross-sectional design involving sixty-three patients with ACS who fulfilled the
inclusion and exclusion criteria. Blood samples were drawn 24 h after onset.
Resistin level was analyzed and classified according to its median values.
The cardiovascular event was defined as mortality, ischemic events, acute
heart failure or arrhythmia during hospitalization. The result showed that
cardiovascular events were significantly higher in patients with resistin levels
higher than median i.e. 23.8% compared to those with resistin levels similar or
lower than median i.e. 11.1% (OR 3.348, 95%CI: 1.125-10.007 p=0.027). It can be
concluded high resistin level is associated with an increase of cardiovascular
events of ACS with intermediate risk GRACE score.

Keywords


resistin; cardiovascular events; acute coronary syndrome; GRACE score; biomarker

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References



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DOI: https://doi.org/10.19106/JMedSci005303202105

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