Relationship between perimenopause symptoms and bone mineral density
https://doi.org/10.19106/JMedScie004601201404
. Aida
(1*) , Djaswadi Dasuki
(2) , Siswishanto Rukmono
(3)
(1) Department of Obstetry and Gynecology, Universitas Gadjah Mada/Dr. Sardjito General Hospital, Yogyakarta
(2) Department of Obstetry and Gynecology, Universitas Gadjah Mada/Dr. Sardjito General Hospital, Yogyakarta
(3) Department of Obstetry and Gynecology, Universitas Gadjah Mada/Dr. Sardjito General Hospital, Yogyakarta
(*) Corresponding Author
Abstract
The menopausal transition or perimenopause is associated with numerous symptoms. Women entering perimonopause normally have menstrual irregular periods due to an imbalance of serum estradiol. Since the status of estrogen is known as an important determinant of bone mass density, menopausal symptoms can be an effective indicator of bone status in women. This study aimed to evaluate the relationship between perimenopause symptoms and bone mineral density (BMD). This was an observational study using cross-sectional design conducted during three months periode from June to August 2010 in Kalangan Village, Banguntapan, Bantul District. Subjects were women between the aged 46-55 years who fulfilled the inclusion and exclusion criteria. After underwent history taking, subjects underwent physical examination according to International Physical Activity Questionnaires (IPAQ). The BMD of subjects was than measured using dual-energy X-ray absorptiometry (DEXA). The relationship between perimenopause symptoms and BMD was then evaluated using multivariate analysis. The results showed that perimenopause symptoms increase abnormal BMD of subjects 1.38 times higher than those without perimenopause symptoms (RR=1.38; 95%CI 1.39-13.78; p=0.01). In conclusion, the perimenopause symptoms is associated with the high proportion of abnormal BMD in women.
Keywords
perimenopause - symptoms - bone mineral density – dual-energy x-ray absorptiometry - estrogen
DOI:
https://doi.org/10.19106/JMedScie004601201404
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Copyright (c) 1970 . Aida, Djaswadi Dasuki, Siswishanto Rukmono
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