The risk factor of metastatic status of retinoblastoma patient in Yogyakarta Tertiary Hospital



Agus Supartoto(1*), Sri Nawung Hartanti(2), Banu Aji Dibyasakti(3), Purjanto Tepo Utomo(4), Datu Respatika(5), Muhammad Bayu Sasongko(6)

(1) Department of Ophthalmology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta
(2) Department of Ophthalmology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta
(3) Department of Ophthalmology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta
(4) Department of Ophthalmology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta
(5) Department of Ophthalmology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta
(6) Department of Ophthalmology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta
(*) Corresponding Author

Abstract


The metastases of the tumor become a serious problem malignancy including retinoblastoma. This study aimed to observe the correlation between several risk factors with the metastatic status of retinoblastoma patients in Yogyakarta Tertiary Hospital. Records of patients with retinoblastoma treated between 2011 and 2017 were obtained for observational analytic study. The gender, laterality, age, Body Mass Index (BMI) classification, BMI for age, type of retinoblastoma, and metastatic status were analyzed. The association was statistically analyzed by the correlation ratio of Eta test. Thirty-seven cases of retinoblastoma were enrolled in this study, with mean age 29.44 (±14.1) months; 14 females and 23 males. Ten patients (27.0%) have no metastases, while 27 patients (72.9%) exhibit metastases. The multivariate logistic regression analysis demonstrated that male gender (OR 8.3; 95% CI 1.07–64.5; p = 0.04) and age below 24 months (OR 17.6; 95% CI 1.26-248.31; p = 0.03) were a predictive of the metastatic status for retinoblastoma. On the other hand, the laterality, BMI classification, BMI for age, and types of retinoblastoma were not associated with the metastatic status of retinoblastoma. The gender and age were significantly associated with the metastatic status of retinoblastoma. Male patients and age below 24 months were more likely to have metastatic disease of retinoblastoma.

Keywords


retinoblastoma - sex - body mass index - familial - metastatic status

Full Text:

PDF


References

Hartono. Mendelisme dalam Oftalmogenetika. Journal of the Medical Sciences (Berkala ilmu Kedokteran). 1988;20(04).

Andreoli MT, Chau FY, Shapiro MJ, Leiderman YI. Epidemiological trends in 1452 cases of retinoblastoma from the Surveillance, Epidemiology, and End Results (SEER) registry. Can J Ophthalmol. 2017;52(6):592-8.

Yun J, Li Y, Xu C-T, Pan B-R. Epidemiology and Rb1 gene of retinoblastoma. International journal of ophthalmology. 2011;4(1):103.

Thompson S, Chinnery H, Noroozi S, Dyer BT, Barratt K. Retinoblastoma: identifying the diagnostic signs for early treatment. International Journal of Neurorehabilitation. 2015;2(2):1-11.

Dimaras H, Corson TW, Cobrinik D, White A, Zhao J, Munier FL, et al. Retinoblastoma. Nature Reviews Disease Primers. 2015;1:15021.

Shields CL, Shields JA. Diagnosis and management of retinoblastoma. Cancer Control. 2004;11(5):317-27.

Natliani F. Agreement between ultrasonography and histopatologic findings in diagnosing retinoblastoma. Journal of the Medical Sciences (Berkala ilmu Kedokteran). 2011;43(01).

Andrassy RJ, Chwals WJ. Nutritional support of the pediatric oncology patient. Nutrition. 1998;14(1):124-9.

Porporato PE. Understanding cachexia as a cancer metabolism syndrome. Oncogenesis. 2016;5:e200.

Bhaskaran K, Douglas I, Forbes H, dos-Santos-Silva I, Leon DA, Smeeth L. Body-mass index and risk of 22 specific cancers: a population-based cohort study of 5.24 million UK adults. Lancet. 2014;384(9945):755-65.

Muscaritoli M, Lucia S, Farcomeni A, Lorusso V, Saracino V, Barone C, et al. Prevalence of malnutrition in patients at first medical oncology visit: the PreMiO study. Oncotarget. 2017;8(45):79884-96.

Maia-Lemos PdS, Ceragioli-Oliveira FL, Monteiro-Caran EM. Nutritional Status at Diagnosis in Children with Cancer in Brazil. Pediatrics & Therapeutics. 2016;6(3):1-d.

Barr R. Nutritional status in children with cancer: Before, during and after therapy. Indian J Cancer. 2015;52(2):173.

Brinksma A. Nutritional status in children with cancer: University of Groningen; 2014.

Brinksma A, Roodbol PF, Sulkers E, Kamps WA, de Bont ES, Boot AM, et al. Changes in nutritional status in childhood cancer patients: a prospective cohort study. Clin Nutr. 2015;34(1):66-73.

Finger PT, Harbour JW, Karcioglu ZA. Risk factors for metastasis in retinoblastoma. Surv Ophthalmol. 2002;47(1):1-16.

Naumova A, Sapienza C. The genetics of retinoblastoma, revisited. Am J Hum Genet. 1994;54(2):264.




Article Metrics

Abstract views : 76 | views : 48




Copyright (c) 2019 Journal of the Medical Sciences (Berkala ilmu Kedokteran)

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

View My Stats

 

Creative Commons License
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) by  Universitas Gadjah Mada is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Based on a work at http://jurnal.ugm.ac.id/bik/.