Abnormality of PaO2 and FiO2 Ratio and Clinical Outcome of Severe Traumatic Brain Injury



Desin Pambudi Sejahtera(1*), Ismail Setyopranoto(2), Indarwati Setyaningsih(3), Sri Sutarni(4), Tri Ratnaningsih(5)

(1) Department of Neurology. Faculty of Medicine, Public Health & Nursing. Universitas Gadjah Mada. Yogyakarta.
(2) Department of Neurology. Faculty of Medicine Public Health & Nursing. Universitas Gadjah Mada. Yogyakarta.
(3) Department of Neurology. Faculty of Medicine, Public Health & Nursing. Universitas Gadjah Mada. Yogyakarta.
(4) Department of Neurology. Faculty of Medicine, Public Health & Nursing. Universitas Gadjah Mada. Yogyakarta.
(5) Department of Clinical Pathology, Faculty of Medicine, Public Health & Nursing, Universitas Gadjah Mada, Yogyakarta
(*) Corresponding Author

Abstract


Introduction:

An accurate prognosis of severe traumatic brain injury (TBI) is still one of the  important challenge for neurologist in order to make a proper decision and good education for patients.

Aim:

Evaluation and assessment the correlation abnormality PaO2 and FiO2 ratio of arterial blood gas analysis (ABG) and the outcome (mortality) of severe TBI.

Method:

In this study, we reviewed the medical records data from severe TBI cases in Sardjito General Hospital from January 2015 untill July 2016. The data consists of age, gender, neuroimaging, ABG, electrolyte, and mortality. Chi square analytic and logistic regression were used to analyse the data significancy and potential confounding factor determination.

Results:

Seventy patients of Severe TBI and 35 of them were died. The analysis of each components and interpretation of ABG showed no significancy between ABG and the mortality of severe TBI. Other factors that has prognostic significance were under 40 of age (OR=1.143, p=0,015), multiple injury (OR=5.712, p=0,045), sistolic blood pressure (OR=3.852, p=0,008), hyponatremia (OR=3.667, p=0,027), hypercalemia (OR=1.771, p=0,030) and subarachnoid hemorrhage (SAH) (OR=6,526, p=0,003).

Conclusion:

Abnormality of PaO2 and FiO2 ratio may not be used as the outcome predictor for severe TBI patients, meanwhile multiple injury, sistolic blood pressure, hyponatremia and SAH may has prognostic value as mortality predictor.

Keywords:

PaO2 and FiO2 ratio, arterial blood gas analysis, mortality, severe traumatic brain injury


Keywords


PaO2 and FiO2 ratio, arterial blood gas analysis, mortality, severe traumatic brain injury



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