Histocompatibility evaluation of combination of gypsum with carbonated hydroxyapatite as bone substitutes in subcutaneous tissue
Dyah Listyarifah Rina Susilowati Ika Dewi Ana
(1*)
(1) 
(*) Corresponding Author
Abstract
Combination of gypsum with carbonated hydroxyapatite (CHA) has shown to improve bone healing process. Soft tissue biocompatibility test is required prior to clinical application of bone substitutes since the materials contact with the soft tissues upon application and can cause severe inflammatory response. The aim of this study was to evaluate histocompatibility of gypsum compared to combination of gypsum-CHA in subcutaneous tissue. Disks of gypsum and gypsum-CHA were implanted on paravertebral subcutaneous tissue of 25 male Wistar rats. Histological section were stained with Hematoxylin Eosin then evaluated and scored with a histological grading scale for softtissue implants. A two-way ANOVA was used to analyze the histomorphometrical results with 95% confidence interval (p<0.05). The results showed that acute inflammatory cells were found in both groups at 6 hour and on day 5 and 7 after implantation at similar level. Chronic inflammatory cells and capsule were observed on day 7, 14, and 21. Moreover, there was no significant difference (p>0.05) of histomorphometrics score between both implants in each implantation periods. It could be concluded that histocompatibility level of gypsum and combination of gypsum- CHA to soft tissue was the same until day 21 iof mplantation. Key words: gypsum - carbonated hydroxyapatite – biocompatibility – histocompatibility - subcutaneous implant
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