Role of NfkB on Mind Body Interventions in Systemic Lupus Erythematosus Patients



Deddy Nur Wachid Achadiono(1*), Nyoman Kertia(2), Achmad Husain Asdie(3), Bambang Udji Djoko Riyanto(4)

(1) Doctoral Programmme Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada / Dr. Sardjito Hospital, Yogyakarta
(2) Departement of Internal Medicine, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada/Dr. Sardjito Hospital, Yogyakarta
(3) Departement of Internal Medicine, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada/Dr. Sardjito Hospital, Yogyakarta
(4) Department of E.N.T and Head – Neck, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada/Dr. Sardjito Hospital, Yogyakarta
(*) Corresponding Author

Abstract


ABSTRACT

 

Mind body interventions (MBIs) emphasize the use of brain in conjunction with the body to assist the healing process as well as to manage symptoms and improve well being. MBIs are expected to be supporting therapy in patients with autoimmune disease such as Systemic Lupus Erythematosus (SLE) to improve patients’ activities and to reduce fatigue, stress, and depression. One type of MBIs that could potentially be applied in Indonesia is Latihan Pasrah Diri. Several studies have shown that MBIs could affect expression of many pro and anti inflammatory mediators. Nuclear factor-κB (NF-κB) is a transcription factor group that controls gene expression related to many physiological responses such as inflammation, proliferation, cell differentiation, and apoptosis. NF-κB target gene is involved in several aspect of immune function, starting from development, activation, and differentiation of lymphocyte up to maturation and inflammatory function of natural immune cells. There are two different pathways for NF-κB activation, consisting of canonical and alternative pathway. This review will discuss about MBIs potential on improving SLE patients condition through NF-κB regulation based on existing studies.

 


Keywords


Mind body interventions; Latihan Pasrah Diri; Nuclear factor-κB; Systemic Lupus Erythematosus





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Journal of the Medical Sciences (Berkala Ilmu Kedokteran) by  Universitas Gadjah Mada is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Based on a work at http://jurnal.ugm.ac.id/bik/.