Molecular subtypes and clinicopathological features of breastcancer
https://doi.org/10.19106/JMedScie004501201306
. Irianiwati
(1*)
(1) Department of Anatomical Pathology, Faculty of Medicine, Universitas Gadjah Mada/Dr. Sardjito General Hospital, Yogyakarta
(*) Corresponding Author
Abstract
Breast cancer is a heterogeneous disease with regard to morphological spectrum, clinical presentation and response to therapy. Based on immunohistochemistry detection of estrogen receptor, progesterone receptor, Her-2 status, proliferation rate and clusters of basal gene expression, breast cancers can be classified into luminal A, luminal B, basal-like/triple negative, and Her-2 positive. It was suggested that there was a close relationship between molecular subtypes and clinicopathological features of breast cancer, as they are very important to predict prognosis and therapeutic implications.
Keywords
molecular subtypes - breast cancer- clinicopathological features -heterogeneity –theraputicimplications
DOI:
https://doi.org/10.19106/JMedScie004501201306
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