Activity of -terpineol as a potential anticancer candidate: cytotoxicity, proapoptotic and antiproliferative evaluation in TD47 cell lines

Abstract

Previous study has shown that -terpineol has a cytotoxic effect on NCI-H69 cancer cell line.
This study aimed to evaluate cytotoxicity, proapoptotic, and antiproliferative activities of -
terpineol in T47D cell lines. The cytotoxic activity of -terpineol was determined using MTT cell
viability assay, while apoptosis was tested by the acridine orange-ethidium bromide staining
method. The cell cycle was evaluated by flowcytometry method. The results showed that -
terpineol had cytotoxic effect on the T47D cells with the IC50 value of 135.00 ± 8.74 M.
Furthermore, -terpineol induced the cells apoptosis in a dose-dependent manner. Flowcytometry
analysis showed that -terpineol induced the T47D cell distribution in Go/G1 phase, however
inhibited cell distribution in S phase. This study suggests that -terpineol has a potential anticancer
activity.