Fibroadenoma of the breast with florid epithelial cells hyperplasia: a case report

Abstract

Fibroadenoma is a benign biphasic tumor of the breast, composed of an epithelial and a stroma component.
Fibroadenoma with epithelial cells hyperplasia may contribute to the higher risk of breast cancer, especially
for florid and atypical hyperplasia. The distinction between fibroadenoma with florid epithelial cells
hyperplasia, in-situ carcinoma and invasive duct carcinoma of the breast ban be difficult morphologically.
To solve the problem, immunohistochemical staining with specific andibodies will be helpfull in distinguishing
usual duct hyperplasia from ductal carcinoma in situ.
A case of fibroadenoma with florid epithelial cells hyperplasia has been reported. Morphologically, this
tumor is difficult to be differentiated from ductal carcinoma. Immunohistochemical staining with High
molecular weight cytokeratins 34BE12, Smooth Muscle Actin (SMA),E-cadherin could be used to determine the
diagnosis of this tumor.