ANTI ACNE CREAM EFFECTIVITY OF METHANOL EXTRACT OF Impatiens balsamina Linn. LEAVES

https://doi.org/10.22146/tradmedj.8851

Abdurraafi' Maududi Dermawan(1*), Liza Pratiwi(2), Indri Kusharyanti(3)

(1) Pharmacy Study Program, Faculty of Medicine, Tanjungpura University
(2) Pharmacy Study Program, Faculty of Medicine, Tanjungpura University
(3) Pharmacy Study Program, Faculty of Medicine, Tanjungpura University
(*) Corresponding Author

Abstract


Many studies have found that Impatiens balsamina leaves contain antibacterial activity. The present study was conducted to evaluate antiacne effect from cream of methanolic extract from leaves of Impatiens balsamina L. towards Propionibacterium acnes and Staphylococcus epidermidis, which concentration that gives the most effective antiacne and to evaluate physical and chemical properties of creams. The simplicia was extracted by soxhlet technique and using methanol as solvent. Kirby-Baeur diffusion method was used to measure the antibacterial activity. The extract was formulated in cream with concentration of 10%, 15% and 20%. Evaluation of physical and chemical properties was done by organoleptic testing, spreadability, adhesive force, pH and antibacterial effectiveness. Data was analyzed using R-Commander program 2.14.1 Version. Formula II which contained 15% extract showed the most effective inhibiton to the growth of bacteria. The evaluation of FII cream showed that the cream was homogen, the spreadability was 21,24 + 1,464cm2, adhesive force more than 60 minutes, and pH of 6,53 + 0,057.


Keywords


Impatiens balsamina leaves, methanol extract, Propionibacterium acnes, Staphylococcus epidermidis

Full Text:

PDF


References

Anief M. 2002. Formulasi Obat Topikal dengan Dasar Penyakit Kulit. Yogyakarta: UGM Press. pp 25.

Betageri G., Prabhu S. 2002. Semisolid Preparation, dalam Swarbick, J. And Boylan, J.C., (Eds.), Encyclopedia of Pharmaceutical Technology, 2nd Ed. New York: Marcel Dekker Inc. 3: 2436, 2453-2456.

Departemen Kesehatan Republik Indonesia. 2000. Parameter Standar Umum Ekstrak Tumbuhan Obat. Jakarta: Direktorat Jenderal Pengawasan Obat dan Makanan.

ICMR. 2009. Detection of Antimicrobial Resistance in Common Gram Negative and Gram Positive Pacteria Encountered in Infectious Deseases- An Update. ICMR Bulletin ISSN 0377-4910 . Vol. 39: 1-3.

Jawetz E., Melnick JL., Adelberg EA., Brooks GF., Butel JS., Ornston LN. 2001. Mikrobiologi Kedokteran. Terjemahan E. Nugroho dan RF. Maulany. ed ke-20. Jakarta: EGC. pp 211-217.

Kielhorn J., Kollmuβ SM., Mangelsdorf I. 2006. Dermal Absorption. Dalam: Environmental health criteria 235. World Health Organization.

Kuswahyuning R., Saifullah. 2008. Teknologi dan Formulasi Sediaan Semipadat. Yogyakarta: Laboratorium Teknologi Farmasi Fakultas Farmasi UGM.

Lim YH., Kim IH., Seo JJ. 2007. In vitro Activity of Kaemferol Isolated from The Impatiens balsamina alone and in Combination with Erythromycin or Clindamycin against Propionibacterium acnes. J Microbiol. 45:420-455.

Muhammad M., Rosen T. 2013. A Controversial Proposal: No More Antibiotics for Acne!. Skin Therapy Letter: Indexed by the US National Library of Medicine and PubMed. 18: 1-4.

Oprica C. 2004. Antibiotic Resistant Propionibacterium acnes on The Skin of Patient with Moderate to Severe Acne. Journal of Pharmacology. 10(3): 155-164.

Plaper A., Golob M., Hafner I., Oblak M., Solmajer T., Jerala R. 2003. Characterization of Quercetin Binding Site on DNA Gyrase. Biochem. Biophy.s Res. Commun. 306: 530–6.

Ray C., Trivedi P., Sharma V. 2013. Review Article: Acne and Its Treatment Lines. Int. J. Res. in Pharm. Biosci. 3(1): 1-16.

Rowe RC., Sheskey PJ., Quinn ME. 2009. Handbook of Pharmaceutical Excipients, 6th Edition. Washington DC: Pharmaceutical Press and American Pharmacist Association. pp 122, 283, 441, 697, 754, 766.

Sakunphueak A., Panichayupakaranant P. 2012. Comparison of Antimicrobial Activities of Naphtoquinones from Impatiens balsamina. Nat Prod Res. 26(12): 1119-1124.

Suardi M., Armenia, dan Maryawati A. 2005. Formulasi dan Uji klinik Gel Anti Jerawat Benzoil Peroksida-HPMC, Karya Ilmiah, Padang, Fakultas Farmasi Universitas Andalas.

Tranggono, RI., dan Latifah F. 2007. Buku Pegangan Ilmu Pengetahuan Kosmetik. Jakarta: PT. Gramedia.

Trommer H., Neubert RHH. 2006. Overcoming The Stratum Corneum: The Modulation of Skin Penetration. Skin Pharmacology and Physiology. 19: 106-121.

Utari P. 2011. Skrining Fitokimia dan Uji Aktivitas Antibakteri Ekstrak Daun dari Tumbuhan Pacar Air (Impatiens Balsamina L.) Terhadap Bakteri Staphylococcus aureus, Staphylococcus epidermidis dan Pseudomonas aeruginosa, Skripsi, Medan, Universitas Sumatera Utara.

Wang YC., Li WY., Wu DC., Wang JJ., Wu CH., Liao JJ., Lin CK. 2009. In Vitro Activity of 2-methoxy-1,4-Naphthoquinone and Stigmasta-7,22 diene-3β-ol from Impatiens balsamina L. Against Multiple Antibiotic-Resistant Helicobacter pylori. Hindawi Publishing Corporation. pp. 1-8.

Wasitaatmadja SM. 1997. Penuntun Ilmu Kosmetik Medik. Jakarta: Penerbit UI-Press. 1997. pp 23.

Wasistaatmadja SM. 2002. Masalah Jerawat Pada Remaja. Di dalam: Tjokronegoro A, Utama A. Pengobatan Mutakhir Dermatologi pada Anak Remaja. Jakarta: FK-UI.



DOI: https://doi.org/10.22146/tradmedj.8851

Article Metrics

Abstract views : 4643 | views : 11357

Refbacks

  • There are currently no refbacks.


Bookmark and Share


Copyright (c) 2020 Majalah Obat Tradisional

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

©Majalah Obat Tradisional (Traditional Medicine Journal)
 ISSN 2406-9086
Faculty of Pharmacy
Universitas Gadjah Mada