Physical Stability, Photostability, and Sunscreen Effectiveness of Combination Cream of Arabica Green Coffee Bean Extract (Coffea arabica) and Octyl Methoxycinnamate

https://doi.org/10.22146/mot.84443

Nanda Tsalasani Zulfaidah(1), Endang Lukitaningsih(2), Abdul Karim Zulkarnain(3*)

(1) Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta
(2) Department of Pharmaceutical Chemistry, Universitas Gadjah Mada, Yogyakarta
(3) Department of Pharmaceutics, Universitas Gadjah Mada
(*) Corresponding Author

Abstract


Arabica green coffee beans (AGCB) have antioxidant compounds as photo protectors. It’s used to stabilize and increase the SPF value of octyl methoxycinnamate in sunscreen because its effectiveness will be decreased when exposed to UV light. The purpose of this study was to determine the effect of a combination of various concentrations of arabica green coffee bean (AGCB) extract and octyl methoxycinnamate (OMC) on the physical properties and SPF value of sunscreen cream. AGCB extract with concentrations (F1) 0%; (F2) 2.5%; (F3) 5%; (F4) 7.5% (with the addition of OMC concentration of 7.5%), and (F5) 7.5% (without the addition of OMC). The formulas were tested for physical properties to determine stability in 4 weeks of storage, cycling test for 4 cycles, and photostability to determine the SPF value and irritation test on the best formula. The results of the physical stability test on the five formulas showed a sig value > 0.05 which means the preparation is stable. Formulas F1, F2, F3, F4, and F5 with exposure of 1 hour, 5 hours, and 10 hours obtained a significance value > 0.05, which means that the presence of UV light exposure in the AGCB extract combination cream can stabilize the decrease in SPF value. Formula 4, which is stable without separation during the cycling test and the stability of the SPF value of 41, then in the irritation test does not cause irritation so it can be concluded that formula 4 is the optimum formula.


Keywords


Arabica green coffee bean extract; Octyl methoxycinnamate; Physical stability; Photostability, SPF

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References

Arianto, A., Cella, G., & Bangun, H. (2019). Preparation and Evaluation of Sunscreen Nanoemulsions with Synergistic Efficacy on SPF by Combination of Soybean Oil, Avobenzone, and Octyl Methoxycinnamate. Open Access Macedonian Journal of Medical Sciences, 7(17), 2751–2756. https://doi.org/10.3889/oamjms.2019.745

Babova, O., Occhipinti, A., & Maffei, M. E. (2016). Chemical partitioning and antioxidant capacity of green coffee (Coffea arabica and Coffea canephora) of different geographical origin. Phytochemistry, 123, 33–39. https://doi.org/10.1016/j.phytochem.2016.01.016

BPOM. (2014). Peraturan Kepala Badan Pengawas Obat Dan Makanan Republik Indonesia Nomor 7 Tahun 2014 Tentang Pedoman Uji Toksisitas Nonklinik Secara In Vivo.

Desai, J., & Mallya, R. (2021). Development of Green Coffee Beans Extract Loaded Anti-aging Liposomal Gel. Indian Journal of Pharmaceutical Education and Research, 55(4), 979–988. https://doi.org/10.5530/ijper.55.4.198

Hamdani, I., & Nurman, S. (2020). Ekstrak Etanol Kopi Hijau Arabika (Coffea arabica L.) sebagai Antihiperglikemi pada Mencit (Mus musculus). Jurnal Kefarmasian Indonesia, 140–147. https://doi.org/10.22435/jki.v10i2.2122

Hamsinah, H., Darijanto, S. D., & Mauluddin, R. (2016). Uji Stabilitas Formulasi Krim Tabir Surya Serbuk Rumput Laut (Eucheuma cottonii. Doty). Jurnal Fitofarmaka Indonesia, 3(2), 155–158. https://doi.org/10.33096/jffi.v3i2.215

Khafifa, I. N., Shabrina, A., & Rochman, M. F. (2022). Stability And Sunscreen Activity Of Nutmeg Seed Oil Emulgel With Carbopol 940 Variation As Gel Base. Jurnal Farmasi Sains Dan Praktis, 167–176. https://doi.org/10.31603/pharmacy.v8i2.6085

Kockler, J., Oelgemöller, M., Robertson, S., & Glass, B. D. (2012). Photostability of sunscreens. Journal of Photochemistry and Photobiology C: Photochemistry Reviews, 13(1), 91–110. https://doi.org/10.1016/j.jphotochemrev.2011.12.001

Kusuma, I. M., Aunillah, S., & Djuhariah, Y. S. (2021). Formulasi Krim Lulur Scrub dari Ekstrak Etanol Ubi Jalar Ungu (Ipomoea batatas (L.) Lam.) dan Serbuk Beras Putih (Oryza sativa L.). Jurnal Farmasi Udayana, 177. https://doi.org/10.24843/JFU.2021.v10.i02.p12

Lia Ningsih, M. A., Lianastuti, M., Suciyanti, Q. P., & Yuniarsih, N. (2022). Potensi Tabir Surya Pada Berbagai Tanaman Herbal. Jurnal Health Sains, 3(6), 757–766. https://doi.org/10.46799/jhs.v4i06.511

Mansauda, K. L. R., Jayanto, I., & Tunggal, R. I. (2022). Stabilitas Fisik Krim Ekstrak Biji Alpukat (Persea Americana Mill.) dengan Variasi Emulgator Asam Stearat dan Trietanolamin.

Nurfita, E., Mayefis, D., & Umar, S. (2021). Uji Stabilitas Formulasi Hand and Body Cream Ekstrak Etanol Kulit Buah Naga Merah (Hylocereus lemairei). Jurnal Farmasi Dan Ilmu Kefarmasian Indonesia, 8(2), 125. https://doi.org/10.20473/jfiki.v8i22021.125-131

Rosita, M. R. E., & Murrukmihadi, M. (2014). Pengaruh Kombinasi Oxybenzone Dan Octyl Methoxycinnamate (Omc)Pada Karakteristik Fisik Dan Spf Dalam Sediaan Krim Tabir Surya.

Rosita, N., Haryadi, D., Erawati, T., Nanda, R., & Soeratri, W. (2017). Photostability Study on Character and Antioxidant Activity of Tomato Extract (Solanum lycopersicum l.) in Nanostructured Lipid Carrier(NLC) and Conventional Creame. International Journal of Drug Delivery Technology, 7(1). https://doi.org/10.25258/ijddt.v7i1.8919

Sari, N. (2021). Uji Aktivitas Ekstrak Metanol Daun Kebiul (Caesalpinia Bonduc L.) Sebagai Bahan Aktif Sediaan Tabir Surya. Journal of Applied Chemistry, 9.

Smaoui, S., Ben Hlima, H., Ben Chobba, I., & Kadri, A. (2017). Development and stability studies of sunscreen cream formulations containing three photo-protective filters. Arabian Journal of Chemistry, 10, S1216–S1222. https://doi.org/10.1016/j.arabjc.2013.02.020

Sugihartini, N., Zainab, Z., Laboratory of Phytochemistry, Faculty of Pharmacy, Universitas Ahmad Dahlan, Yogyakarta, Pamungkas, A., & Undergraduate Program Study of Pharmacy, Faculty of Pharmacy, Universitas Ahmad Dahlan, Yogyakarta. (2021). Physical Stability Test And Ethanol Cream Irritation Test Of Moringa oleifera L. Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi Dan Kesehatan, 6(2), 186–195. https://doi.org/10.36387/jiis.v6i2.675

Sutarna, T. H., Alatas, F., & Ratih, H. (2015). Pengaruh Penambahan Vitamin C sebagai Antioksidan terhadap Nilai Sun Proctective Factor (Spf) dari Oktil Metoksisinamat. 4.

Zulkarnain, A. K., Faridhotu, F., & Pr, I. N. (2022). Optimization of Gelling Agent of Sunflower (Helianthus annuus) Seed Oil Gel and Its Stability and Activity Test In Vitro as Sunscreen. Majalah Obat Tradisional, 27(3), 247. https://doi.org/10.22146/mot.80299



DOI: https://doi.org/10.22146/mot.84443

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