Physical Stability of Binahong Leaf Extract (Anredera cordifolia (Ten.) Steenis) with Hydroxypropyl Methylcellulose and Hydroxyethyl Cellulose Gelling Agents

https://doi.org/10.22146/mot.82983

Siska Purnama Sari(1), Abdul Karim Zulkarnain(2*)

(1) Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta
(2) Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta
(*) Corresponding Author

Abstract


Second-degree burns have the highest prevalence and often occur in the household environment. The healing process can be accelerated by traditional medicine. One of the many plants known to have wound-healing abilities is the Binahong plant (Anredera cordifolia (Ten.) Steenis). The gel preparation is chosen because of the many benefits it can provide. The gelling agents used were Hydroxypropyl Methyl Cellulose and Hydroxyethyl Cellulose. The combination of these gelling agents was chosen because both agents are capable of producing gel preparations with good stability during storage. Therefore, the optimization was carried out to obtain the optimum formula that met the requirements. The observed responses were organoleptic, pH, spreadability, adhesion, viscosity, and homogeneity. The data obtained was optimized with the Simplex Lattice Design program in Design Expert software version 13.0.0. The results of the verification test were compared for their significance with the T-test with a 95% confidence level. The optimum gel stability of Binahong leaves (Anredera cordifolia (Ten.) Steenis) was tested using one-way ANOVA and post hoc. The results showed that the optimum formula for Binahong leaf extract gel (Anredera cordifolia (Ten.) Steenis) was obtained with a composition ratio of 0.5% HPMC and 4.5% HEC. The verification results obtained valid values for pH response, viscosity, and spreadability according to SLD predictions. The optimum formula for Binahong leaf extract gel (Anredera cordifolia (Ten.) Steenis) was stable during the cycling test.

 


Keywords


Binahong leaves; physical stability; gel

Full Text:

PDF


References

Angelia, 2022, Formulasi Spray Gel Ekstrak Kulit Jeruk Manis (Citrus sinensis L.) sebagai Anti-aging [Spray Gel Formulation of Peel of Sweet Orange Extract (Citrus sinensis L.) as Anti-Aging], Journal of Research in Pharmacy.

Ansel, 1989, Pengantar Sediaan Farmasi. Jakarta: UI-Press.

Ariani, A. P., (2014), Aplikasi Metodologi Penelitian Kebidanan Kesehatan Reproduksi, Yogyakarta: Nuha Medika.

Barel A.O., Paye M. and Maibach H.I., 2009. Handbook of Cosmetic Science and Technology, 3rd Edition., Informa Healthcare USA, Inc., New York.

Effendy, (1999), Perawatan Pasien Luka Bakar, Jakarta: EGC.

Garg, A., Anggarwal, D., Garg, S., dan Singla, A.K, 2022, Spreading of Semisolid Formulation: An Update. Pharmaceutical Technology, USA 84-104.

Langenbucher & Lange, 2007, Teori dan Praktek Farmasi Industri II . Edisi III, Jakarta: Universitas Indonesia Press.

Laverius, M.F., 2011. Optimasi Tween 80 Dan Span 80 Sebagai Emulsifying Agent Serta Carbopol Sebagai Gelling Agent Dalam Sediaan Emulgel Photoprotector Ekstrak Teh Hijau (Camellia sinensis L.): Aplikasi Desain Faktorial. Graduating paper, B. Pharm.

Manoi, F., 2009, Binahong (Anredera cordifolia)(Ten) Steenis Sebagai Obat, Jurnal Warta Penelitian Dan Pengembangan Tanaman Industri, 15(1).

Marchaban, Fudholi, A., Sulaiman, T.N.S., Mufrod, Martin, R., Bestari, A.N., 2015, Seri Buku Petunjuk Praktikum Teknologi Farmasi: Teknologi Formulasi Sediaan Cair Semi Padat, Pharmaceutical Technology Laboratory, Faculty of Pharmacy, UGM, Yogyakarta.

Martin, A., Swarbrick, J., dan Cammarat, A, 2012, Farmasi Fisik Dasar-Dasar Farmasi Fisik Dalam Ilmu Farmasetik, Jakarta, UI-Press, 1077.

Naibaho, D.H., Yamkan, V,Y., Wiyono. (2013). Pengaruh Basis Salep Terhadap Formulasi Sediaan Salep Ekstrak Daun Kemangi(Ocinum sanchum L.) pada Kulit Punggung Kelinci yang dibuat Infeksi Staphylococcus aureus. Jurnal ilmiah Farmasi, Universitas Sam Ratulangi. Vol.2 N0.02.

Sari L.W.K., Pratiwi P.Y., Widiastuti R., 2021. Formulation and Physical Stability Test for The Preparation of Binahong Leaf (Anredera cordifolia) Ethanol Scrub Cream Extract with Variations of Emulgator Levels. Jurnal Jamu Kusuma, Vol. 1, No. 2 December 2021, pp. 84-95.

Tambunan, S., & Sulaiman, T. N. S. 2018. Gel Formulation of Lemongrass Essential Oil with HPMC and Carbopol Bases, Majalah armaseutik, 14(2), 87-95.

Tranggono, R., & Latifah, F., 2007, Buku Pegangan Ilmu Pengetahuan Kosmetik. Jakarta: PT. Gramedia Pustaka Utama.

Voight, R., 1995, Buku Pelajaran Teknologi Farmasi Edisi V, Yogyakarta: Gajah Mada University Press.

Yati, K., Jufri, M., Gozan, M., Mardiastuti, M., & Dwita, L. P. 2018, The Effect of Hidroxy Propyl Methyl Cellulose (HPMC) Concentration Variation on Physical Stability of Tobacco (Nicotiana tabaccum L.) Extract Gel and Its Activity Against Streptococcus mutans, Pharmaceutical Sciences and Research, 5(3), 4.

Zatz, J., & Kushla, G., 1996, Gels. In: H.A. Lieberman, Pharmaceutical Dosage Forms Disperse System, New York: Marcell Dekker Inc.

Zulkarnain, A.K., Faridhotu, F., Naqsya, I., 2022, Optimization of Gelling Agent of Sunflower (Helianthus annuus) Seed Oil Gel and Its Stability and Activity Test In Vitro as Sunscreen, Traditional Medicine Journal Vol. 27 No. 3:247-256.

Zulfa E., Lailatunnida L., Murukmihadi M., 2018, Formulasi Sediaan Krim Daun Binahong (Anredera cordifolia (Ten.) Steenis): : Kajian Karakteristik Fisika Kimia dan Uji Iritasi Kulit, Jurnal Inovasi Teknik Kimia, 3(1), pp. 46-52



DOI: https://doi.org/10.22146/mot.82983

Article Metrics

Abstract views : 1830 | views : 1239

Refbacks

  • There are currently no refbacks.


Bookmark and Share


Copyright (c) 2023 Majalah Obat Tradisional

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

©Majalah Obat Tradisional (Traditional Medicine Journal)
 ISSN 2406-9086
Faculty of Pharmacy
Universitas Gadjah Mada