THE EFFECT OF COMBINATION OF Curcuma xanthorrhyza Roxb, GINGER, SOYBEAN AND SHRIMP EXTRACTS IN COMPARISON TO DICLOFENAC SODIUM TO LIVER AND KIDNEY FUNCTION OF PATIENTS WITH OSTEOARTHRITIS

https://doi.org/10.22146/tradmedj.8253

Nyoman Kertia(1*), Nastiti Hemas M.(2), Dewa Ayu G. N.(3)

(1) Faculty of Medicine, Universitas Gadjah Mada RSUP Dr. Sardjito
(2) Faculty of Medicine, Universitas Gadjah Mada
(3) Faculty of Medicine, Universitas Gadjah Mada
(*) Corresponding Author

Abstract


Objectives To evaluate the effect of Curcuma xanthorrhyza Roxb extract, ginger, soybean and shrimp shell in combination compared to diclofenac sodium to liver and kidney function of patients with osteoarthritis. Methods twenty one subjects randomly allocated to different groups (Trial and control = diclofenac group). The trial group were treated by the combination of 50 mg temulawak extract, 100 mg ginger, 50 mg soybean and 100 mg shrimp shell three times daily while the control groupwere treated by 25 mg diclofenac sodium three times daily for a couple of week. Blood sample was obtained before and after two weeks therapy to determine the liver enzymes SGOT and SGPT and also serum ureum and creatinin in order to monitor the kidney function. The study was a prospective randomized open end blinded evaluation (PROBE). Result both trial and diclofenac group show significantly increase of SGOT levels (p<0.05) but the difference change among these groups are not significant (p=0.312). In the trial group there was decreasing of SGPT level (p=0.871) whereas there was an increase in level of SGPT in diclofenac group (p=1.000) although the difference between these two was not statistically significant (p=0.912). The change of serum ureum and creatinin level were not significantly different in trial group compared to diclofenac (p>0.05). In the trial group there was decreasing of serum ureum level although not significant (p=0.214). Both trial and diclofenac group showed no statistically significant increasing of creatinin serum levels (p>0.05). Conclusion there is no statistically difference effect between using the combination of temulawak extract, ginger, soybean and shrimp shell compared to diclofenac sodium toward liver and kidney function of osteoarthritis patients during this two weeks treatment.

Keywords


Osteoarthritis, Temulawak, Ginger, Soybean, Shrimp Shell, Diclofenac, Liver Function, Kidney Function



References

Ahmed,S., Anuntiyo, J., Malemud, C.J., Haqqi, T.M., 2005, Biological Basis for the Use of Botanicals in Osteoarthritis and Rheumatoid Asthritis : A Review. Comp.Alt.Med. 2 : 301 – 08

Ajith T.A., Hema U., Aswaty M.S., 2007, Zingiber officinale Roscoe Prevents Acetaminophen – induced Hepatotoxicity by Enhancing Hepatic Antioxidant Status. Food and Medical Toxycology.45:2267-72

Anandita, D.W., 2010, Pengaruh Minyak Atsiri & Ekstrak Etanoik Bebas Minyak Atsiri Rimpang Jahe Merah Terhadap Efek Aprosidiaka Pada Tikus Jantan. KTI Farmasi UGM Yogyakarta

Arjmandi, B.H., 2004, Soy Protein May Alleviate Osteoarthritis Symptoms. Phytomedicine. Phytomedicine 11 : 567 – 575

Benhamou, J.P., 1988, Drug – Induced Hepatitis : Clinical Aspects. In : Guillouzo, A., (Ed): Liver Cells and Drugs vol.164. John Liberty Eurotext, London. pp : 3 – 12

Brouet, I., Ohshima, H., 1995, Curcumin, an Anti-tumour Promoter and Anti-inflammatory Agent, Inhibit Induction of Nitric Oxide Synthase in Active Macrophage. Biochem.Biophys. Res. Comm. 206:533-40

Clegg, D.O., Reda, D.J., Haris, C.L., 2006, Glucosamine, Chondroitin Sulfat, and the Two in Combination For Painfull Knee Osteoarthritis. N Eng J Med 354 : 795 – 808

Cohly, H. H., Taylor, A., Angel, M. F., Salahudeen, A. K., 1998, Effect of Turmeric, Turmerin and Curcumin on H2O2 Induced Renal Epithelial Cell Injury. Free Radic. Med. 24:49-54

Dieppe, P.A., 2008, Osteoarthritis: Clinical Feature in Klippel, J. H., Stone, J. H., Crofford, L. J., White, P. H. (eds) Primer on The Rheumatic Diseases, 13th ed., pp. 224-28

Golden, B. D., Abramson, S. B., 1999, Selective Cyclooxygenase-2 Inhibitors.Rheum. Dis. Clin. North. Am. 25:359-78

Haghighi, A., Tavalei, N., Owlia, M.B., 2006, Effect of Ginger on Primary Knee Osteoarthritis.Indian Journal of Rheumatology.1(1) : 3–7

Hamden, K., 2009, Inhibitory Effect of Estrogen, Phytoestrogen and Caloric Restriction on Oxidative Stress and Hepatotoxicity in Aged Rats.Biomedical and Environmental: 381 - 387

Handoko, Iwan, S., 2003, Tes Fungsi Hati. http://www.klinikku.com.

Isbagio, H., 2000, Osteoartritis dan Artritis Reumatoud – Perbedaan Patogenensis, Gambaran Klinis dan Terapi.Cermin Dunia Kedokteran .129 : 5 - 8

Joe, B., Vijaykumar, M., Lokesh, B. R., 2004, Biological Properties of Curcumin, Cellular and Molecular Mechanisms of Action. Critic. Rev. Food Sc. Nut. 44:97-111

Kertia N., 2009, Aktivitas Anti – Inflamasi Kurkuminoid Ekstrak Rimpang Kunyit [disertasi]. Universitas Gadjah Mada, Yogyakarta

Kertia, N., 2004, Peran Preferentially Selective COX Inhibitor dalam Pengobatan Nyeri Rematik dalam Simposium Osteoporosis, Nyeri rematik dan Stroke, hal 3 – 14. Fakultas Kedokteran Universitas Gadjah Mada, Yogyakarta

Kertia, N., Danang., Broto, R., Rahardjo, P., Asdie, A. H., 2000, Increase Quality of Service for Patients with Osteoarthritis by Using the Combination of Curcuminoid and Curcumin’s Atsiri Oil in Abstract of 9th Asia Pacific League of Associations for Rheumatology Congress, pp 273. Beijing

Lemeshow, S., Hosmer, J.R., Lwanga, S.K., 1990,.Adequacy of Sample Size in Health Studies.John Willey & Sons, New York

Liu, S.Q., Qiu, B., Chen, L.Y., Peng, H., Du, Y.M., 2005, The effects of carboxymethylated chitosan on metalloproteinase-1, -3 and tissue inhibitor of metalloproteinase-1 gene expression

Novita, Rahma., 2000, Efek Pemberian Ekstrak Rimpang Jahe Emprit Terhadap Penurunan Sel Radang Pada Hepar Tikus Jantan Galur Wistar Akibat Stres. KTI Farmasi UGM Yogyakarta

O’Connor, N.,Dargan, P.I., Jones, A.L., 2003, Hepatocellular Damage from non steroidal anti – inflammatory drugs.Q J Med ; 96 : 787–791

Osman, M., Fayed, S.A., Mahmoud, G.I., Remoeilah, R.M.,2010, Protective Effect of Chitosan, Ascorbic Acid and Gymnema sylvestre Againts Hypercholesterolemia in Male Rats.Australian Journal of Basic and Applied Science 4(1) : 89-98

Pravitasari, Lucy., 2006, Pengaruh Pemberian Ekstrak Air Daun Jambu Biji (Psidium Guajava Linn) Terhadap Kadar Kreatinin dan Urea Serum Tikus Putih (Rattus Norvegicus) Jantan. KTI Farmasi UGM Yogyakarta

Psaty, B., Furberg, C., 2005, COX-2 Inhibitors - Lessons in Drug Safety.N. Engl. J. Med. 352:11-17

Rahmawati, Y., 2006, Perbandingan Efek Samping Ekstrak Kunir dan Natrium Diklofenak Terhadap Fungsi Hati pada Pasien Osteoartritis Lutut.[Skripsi],Yogyakarta

Saladin,K.S., 2007, Anatomy and Physiology 4 ed. McGraw.Hill, New York

Salahuddin A, Jeremy A, Charles J.M., Tariq M.H., 2005, Biological basis for the Use of Botanicals in Osteoarthritis and rheumatoid Arthritis : A Review, Oxford Journals, Vol 2; 3: 301-08

Sampurno., 2004, Informasi Temu Lawak Indonesia.Badan Pengawas Obat dan Makanan Republik Indonesia, Jakarta

Sangha, O., 2000, Epidemiology of Rheumatic Diseases.Rheumatology; 39 (Suppl.2) : 3 – 12

Santosa, Ali., 2000, Pengaruh Ekstrak Kunyit & Temulawak Dibanding Piroksikam pada Penurunan Kadar Proteoglikan dan Kepadatan Serabut Kolagen Cairan Sendi Penderita Osteoartritis Lutut. KTI Fak. Kedokteran UGM, Yogyakarta

Scott, D.L., Smith, C., Lohmander, L.S., Chard, J., 2003,Osteoarthritis.Clin Evid; 11 : 1560 -1588

Song R.J., Kim J.W., Kang K.Y., 2010. Hepatoprotective Effect of Chitosan Oligosaccharides on CCl4- induced Lier Injury in Rats. J. Chitin Chitosan. 15(2) : 80-87

Thapa, B.R., Walia. A., 2007, Liver Function Tests and Their Interpretation dalam Jurnal Simposium Newer Diagnostic Test. Indian Journal of Pediatrics : 74. Chandigarh

Tseng, C. C., Wolfe, M. M., 2000, Nonsteroidal Anti-inflamatory Drugs. Med. Clin. North. Am. 84:1329-44

Yassin, N.A.Z., ElRokh, E.M., El-Shenawy, S.M.A., Ehasn, N.A., Sayed, W.H., Hassanein, H.M.D.E., Ibrahim, B.M.M., 2010, Study of The Hepatoprotective Effect of Ginger Aqueous Infusion in Rats. Journal of Chemical and Pharmaceutical Research.2(4):476-488



DOI: https://doi.org/10.22146/tradmedj.8253

Article Metrics

Abstract views : 2087 | views : 3342

Refbacks

  • There are currently no refbacks.


Bookmark and Share


Copyright (c) 2015 Majalah Obat Tradisional

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

©Majalah Obat Tradisional (Traditional Medicine Journal)
 ISSN 2406-9086
Faculty of Pharmacy
Universitas Gadjah Mada