THE PHYSICAL STABILITY OF LOTION O/W AND W/O FROM Phaleria macrocarpa FRUIT EXTRACT AS SUNSCREEN AND PRIMARY IRRITATION TEST ON RABBIT

https://doi.org/10.22146/tradmedj.8216

Abdul Karim Zulkarnain(1*), Meiroza Susanti(2), Aliva Nur Lathifa(3)

(1) Faculty of Pharmacy, Universitas Gadjah Mada
(2) Faculty of Pharmacy, Universitas Gadjah Mada
(3) Faculty of Pharmacy, Universitas Gadjah Mada
(*) Corresponding Author

Abstract


Phalerin in extract of Phaleria macrocarpa fruit has activity as a sunscreen. The aims of this research was to discover the physical stability of extract in lotion  and primary irritation test. The optimal formulation o/w was determined by Simplex Lattice Design (LSD) method using software Design Expert® version 8.0.7 with variety of cetyl alcohol, stearic acid, and triethanolamine and lotion w/o with variety of cera alba, span 80 and cetyl alcohol. Lotion was made in 10 optimum formula then the physical characteristics were measured. The phycical characteristics was employed to create the optimum formula. The difference of physical characteristic between experimental and software was analyzed by one sample t-test analysis statistics. Optimum formula of lotion was determined on skin white rabbit. The optimum formula lotion o/w were cetyl alcohol 2,690%, stearic acid 4,146%, and triethanolamine 3,164% and lotion w/o were cera alba 12,136%; span 80 7,181%; and cetyl alkohol 3,683%. The result of one sample t-test gave no signifficant differences on physical characteristics between experimental and software. Optimum formula of lotion o/w was not irritant at topical on white rabbit skin.


Keywords


Phaleria macrocarpa, lotion, stability, SLD, in vivo



References

Ansel, H.C., 1989, Pengantar Bentuk Sediaan Farmasi, diterjemahkan oleh Farida Ibrahim, Cetakan I, 376, 519, UI Press, Jakarta

Bonner, M.C., 2009, Lanolin, dalam Rowe, R.C., Sheskey, P.J., and Quinn, M.E., Handbook of Pharmaceutical Excipients, 6th Ed, 380, Pharmaceutical Press, London

Dalimartha, S., 2003, Atlas Tumbuhan Obat Indonesia, Jilid III, 62-65, Trubus Agriwidya, Jakarta

Finnen, M. J., cit Rahmi & Iqmal, 2005, Analisis in Silico Aktivitas Tabir Surya Senyawa Turunan Oksibenzon Menggunakan Perhitungan Orbital Molekul Semiempirik Zindo/s, Jurnal Farmasi Indonesia, vol. 2 No. 1, 2

Glaister, J.R., 1986, Priciples of Toxicological Pathology, Taylor and Francis, London

Halliwel, B., and Gutteridge, J. M. C., 1999, Free Radical in Biology and Medicine, Oxford University Press, New York

Lachman, L., Lieberman, H.A., and Kanig, J.L., 1994, Teori dan Praktek Farmasi Industri, diterjemahkan oleh Siti Suyatmi, Jilid 2, Edisi III, 1081, Penerbit Universitas Indonesia Press, Jakarta

Lu, F.C., 1995, Toksikologi Dasar, Asas, Organ Sasaran, dan Penilaian Risiko, diterjemahkan oleh Nugroho, E., Edisi kedua, UI-Press, Jakarta

Owen, S.C., 2005, Mineral Oil, dalam Rowe, R.C., Sheskey, P.J., and Owen, S.C., Handbook of Pharmaceutical Excipient, Fifth Edition, 471-473, Pharmaceutical Press, London

Pradiptayani, S.L., 2011, Stabilitas Fisik dan Aktivitas Lotion o/w Ekstrak Etanolik Buah Mahkota Dewa [Phaleria macrocarpa (Scheff.) Boerl.] Sebagai Tabir Surya Pada Mencit, Skripsi, Fakultas Farmasi Universitas Gadjah Mada, Yogyakarta

Price, J.C., 2005, Glycerin, dalam Rowe, R.C., Sheskey, P.J., and Owen, S.C., Handbook of Pharmaceutical Excipients, 301-301, Pharmaceutical Press, London

Perwitasari, I, Chandra, D.K., Etnawati dan Suyoto, 1999, Peran Tabir Surya Kombinasi Sinamat dan Benzophenon pada Perubahan Warna Kulit Konstitutif Akibat Pajanan UV-B, Kumpulan Jurnal Kosmetik Medik, FKU-UGM, Yogyakarta

Raspanti, 1997, cit Rahmi & Iqmal, 2005, Analisis in Silico Aktivitas Tabir Surya Senyawa Turunan Oksibenzon Menggunakan Perhitungan Orbital Molekul Semiempirik Zindo/s, Jurnal Farmasi Indonesia, vol. 2 No. 1, 2

Trilestari, 2002, Hand and Body Lotion : Pengaruh Penambahan Nipagin, Nipasol, dan Campuran Keduanya Terhadap Stabilitas Fisika dan Efektifitasnya sebagai Anti Jamur, Skripsi, Fakultas Farmasi Universitas Gadjah Mada, Yogyakarta

Wahyuningsih, M.S., Mubarika, S., Gandjar, I.G., Hamann, M.T., Rao, K.V., dan Wahyuono, S., 2005, Phalerin, Glukosida Benzophenon Baru Diisolasi dari Ekstrak Metanolik Mahkota Dewa [Phaleria macrocarpa (Scheff) Boerl.], Majalah Farmasi Indonesia, 16(1), 51-57

Wasitaatmadja. S.M., 1997, Penuntun Ilmu Kosmetik Medik, Universitas Indonesia Press, Jakarta

Yunita, Vidya, 2011, Stabilitas Fisik dan Aktivitas Sediaan Lotion W/O Ekstrak Etanolik Buah Mahkota Dewa [Phaleria macrocarpa (Scheff) Boerl.] sebagai Tabir Surya pada Mencit, Skripsi, Fakultas Farmasi Universitas Gadjah Mada, Yogyakarta



DOI: https://doi.org/10.22146/tradmedj.8216

Article Metrics

Abstract views : 817 | views : 3481

Refbacks

  • There are currently no refbacks.




Copyright (c) 2015 Majalah Obat Tradisional

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

©Majalah Obat Tradisional (Trad.Med.J) 
Faculty of Pharmacy
Universitas Gadjah Mada