Alissya Swastika NSP(1), Mufrod Mufrod(2), Purwanto Purwanto(3*)

(1) Faculty of Pharmacy, Universitas Gadjah Mada
(2) Faculty of Pharmacy, Universitas Gadjah Mada
(3) Faculty of Pharmacy, Universitas Gadjah Mada
(*) Corresponding Author


Premature aging skin condition characterized by dry, scaly, rough and accompanied by the appearance of wrinkles and dark spots or blemishes has become to be a women fearing thing, especially among women in reproductive age. Factors causing premature aging are internal factors (health, stamina, stress and hormonal changes) and external factors (free radicals, sunlight and pollutants). Free radicals can be prevented by antioxidant compounds either synthetic or natural materials. Tomato is one of the natural antioxidants. The most antioxidant content in tomato is lycopene. Tomato is used in the form of tomato juice made by extraction method. Tomato in their use directly is less effective so that tomato is made in the form of cream. Cream compositions were made by variation concentration of tomato juice (5%, 10%, 15%, and 20%). The antioxidant activity was tested by DPPH method. Physical stability parameters tested in this research were homogenity, viscosity, dispersive power, adhesion, cream separation ratio and pH. Data were analyzed by Kolmogorov-Smirnov test, one way ANOVA test and Tukey test. Organoleptic test data, the physical properties of the cream, and the type of emulsion were analyzed descriptively .The results showed that tomato juice has antioxidant activity with IC50 value 2,69%. The increase in the concentration of tomato juice gave significantly different results in all formulas except the formulas III and IV that were not significantly different. The IC50 values cream of tomato juice were 9,12%; 708%; 3,61%; and 2,85% respectively for the cream with tomato extract concentration of 5%, 10%, 15%, 20%. This showed that the higher the concentration of tomato juice, the higher the antioxidant activity as indicated by the lower of IC50 value. The increase in the concentration of tomato juice as active ingredients provided significantly different results for difference antioxidant activity, color, and smell, but did not cause significant differences in the consistency, viscosity, dispersive power, time and pH.


cream, tomato juice, antioxidant, DPPH method


Ansel, H.C., Allen L.V, dan Popovich, N.G., 1999, Pharmaceutical Dosage Forms and Drugs Delivery System, pp. 364-374, Lippincott Williams & Willems, Philadelphia

Dwiastuti, R., 2007, Optimasi Proses Pembuatan Krim Sunscreen Ekstrak Kering Polifenol Teh Hijau (Camelia sinensis L.) dengan Metode Desain Faktorial, Tesis, Fakultas Farmasi, Universitas Gadjah Mada, Yogyakarta

Lachman, L., Lieberman, H.A. dan Kanig, J.L, 1986, Teori dan Praktek Farmasi Industri, diterjemahkan oleh Siti Suyatmi, Ed. III, 1076-1088, UI Press, Jakarta

Martin, A., Swarbick, J. dan Cammarata, A., 1993, Farmasi Fisik 2, Dasar-dasar Kimia Fisik dalam Ilmu Farmasetik, diterjemahkan oleh Yoshita, Edisi III, 1143, 1151, 1157, 1162, Universitas Indonesia Press, Jakarta

Molllet, H. dan Grubenmann, A., 2001, Formulation Technology Emulsions, Suspensions, Solid Forms, diterjemahkan oleh Payne, H.R., 59-62, 177, 259-262, Willey-VCH, Weinheim

Prior, R.L., Wu, X., and Schaich, K., 2005, Standardized Methods for the Determination of Antioxidant Capacity and Phenolic in Foods and Dietary Supplements, J. Agric. Food Chem., 55, 2698A-J

Sibuea, P., 2003, Antioksidan Senyawa Ajaib Penangkal Penuaan Dini, Sinar Harapan, Yogyakarta

Wasitaatmadja, S.M., 1997, Penuntun Ilmu Kosmetik Medik, Universitas Indonesia Press, Jakarta

Windono, T., 2001, Uji Peredam Radikal Bebas Terhadap 1, 1-Diphenyl-2-picrylhidrazil (DPPH) dari Ekstrak Kulit Buah dan Biji Anggur (Vitis vinifera) Probolinggo biru dan Bali, Artikel Hasil Penelitian, Artocarpus, Vol I no.1: Fakultas Farmasi UNAIR, Surabaya hal 34–43

Zhao, Y.P., Turay R. Dan Hundley L., 2007, Monitoring and Predicting Emulsion Stability of Metal Working Fluids by Salt titration and Turbiscan,, diakses tanggal 6 Januari 2013


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