EFFERVESCENT TABLETS FORMULATION OF GINGER RHIZOME (Zingiber officinale Rosc.) WITH VARIATION OF CITRIC ACID AND TARTARIC ACID LEVEL

https://doi.org/10.22146/tradmedj.8082

Mufrod Mufrod(1*), Sekararum Diah Kartikasari(2), Yosi Bayu Murti(3)

(1) Faculty of Pharmacy, Universitas Gadjah Mada
(2) Faculty of Pharmacy, Universitas Gadjah Mada
(3) Faculty of Pharmacy, Universitas Gadjah Mada
(*) Corresponding Author

Abstract


Ginger (Zingiber officinale Rosc.) has efficacy as an anti-emetic. Ginger rhizome is usually consumed as instant beverages, so that need to be made into a dosage form that more effective, efficient and attractive. This research aims to formulate ginger into effervescent tablets by using variation of the levels of citric acid and tartaric acid. Dried extract of ginger was made with percolation method using ethanol 70% and evaporated using spray dryer. Extract was made for 5 formulas with variation of acid source using smelting method. Granules were tested its physical properties include flow time, tap index, angle of repose, water absorption, compactibility, mass density, water content, and total phenolic level. Granules were compressed become tablets and tested for physical properties include weight uniformity, friability, hardness, dissolve time, flavor response test and total phenolic level. Data were analyzed with Anova One Way using 95% confidence level. The result shown that formula III was the best formula because it meets the physical requirements of granules and tablets. While the formula V (100% tartaric acid) was a formula that provides the greatest stability phenolic levels.


Keywords


Zingiber officinale Rosc. (jahe), effervescent tablet, variation of acid source



References

Anonim, 1979, Farmakope Indonesia Edisi III, 7, 510, Departemen Kesehatan RI, Jakarta

Ansel, H.C., Allen, L.V., dan Popovich, N.G., 1999, Pharmaceutical Dosage Forms and Drug Delivery System, 7th Ed., 168, 176,178, Lippincott Williams and Wilkins, Philadelphia

Banker, G.S., dan Anderson, N.R., 1986, Tablets, dalam Lachman, L., Lieberman, H.A., dan Kanig, J.L., (Eds), The Theory and Practice of Industrial Pharmacy 3rd Ed., 299, 311-318, 326, 328, 334, Lea & Febiger, Philadelphia

Chaudry, M.A., Bibi, N., Khan, F., dan Suttara, 1998, Phenolics and Quality of Solar Cabinet Dried Persimmon During Storage, Ital. J. Food Sci., 10, 269-275

Ebadi, M.S., 2002, Pharmacodynamic Basis of Herbal Medicine, 145, CRC Press, Florida

Fassihi, A.R., dan Kanfer, I., 1986, Effect of Compressibility and Powder Flow Properties on Tablet Weight Variation : Drug Development and Industrial Pharmacy, 12th Ed., 321-358, Marcel Dekker Inc., New York, cit Priati, R.D., 2007, Tablet effervescent Ekstrak Kelopak Bunga Rosela (Hibiscus sabdariffa L.) dengan Berbagai Vaiasai Sumber Asam, Skripsi, Fakultas Farmasi, Universitas Gadjah Mada, Yogyakarta

Fransisco, M.L., 2008, Total Phenolic and Antioxidant Capacity of Heat-Treated Peanut Skins, Journal of Food Composition and Analysis, 22s, 16-24

Fudholi, A., 1983, Metodologi Formulasi dalam Kompresi Direk, Medika, no.7, 586-593, tahun ke-9 cit Santoso, I.B., 2006, Pembuatan Tablet Effervescent Fraksi Kurkuminoid Temulawak (Curcuma xanthorriza Roxb.), Skripsi, Fakultas Farmasi, Universitas Gadjah Mada, Yogyakarta

Halim, R.G., 2008, pengaruh Pemberian Ekstrak Etanolik Jahe Emprit pada Tikus Jantan Galur Wistar terhadap Pengososngan Lambung (Symptom sekunder Motion Sickness), Skripsi, Fakultas Farmasi, Universitas Gadjah Mada, Yogyakarta

Hutapea, J.R., 2001, Inventaris Tanaman ObatIndonesia (I) Jilid 2, 347-348, Departemen Kesehatan danKesejahteraan Sosial RI Badan Penelitian dan Pengembangan Kesehatan, Jakarta

Mohrle, R., 1980, Effervescent Tablets dalam Lieberman, H.A., dan Lachman L., (Eds), Pharmaceutical Dosage Forms : Tablets, Volume I, 226-230, 240, Marcel Dekker Inc, New York & Basel

Panjaitan, E.S., Saragih, A., purba, D., 2012, Formulasi Gel dari Ekstrak Rimpang Jahe Merah (Zingiber officinale Rosc.), Journal of Pharmaceutics and Pharmacology, 1(1) : 9-20

Parrott, E.L., 1971, Pharmaceutical Technology Fundamental Pharmaceutics, 3rd Ed,82, Burgess Publishing Company, Minneapolis

Prior, R.L., Wu, X., dan Schaich, K., 2005, Standardized method for the determination of antioxidant capacity and phenolic in food and dietary supplements, J. Agric.Food Chem., 53, 4290-4302

Singleton, V., Orthofer, R., dan Lamuela-Raventos, R., 1999, Analysis of Total Phennnols and Other Oxidation Substrates and antioxidants by Means of Folin-Ciocalteu reagent, dalam L.Parkeer (Ed.), Oxidants and Antioxidants Part A ,,, Methods inEnzymology, Vol 299, 152-178, Academic press, New York cit Hinneburg, I., Dorman, H., J.Hilyunen, R., 2005, Antioxidant Activities of Extracts from selected Culinary Herbs and Spices, J.Food Chem, 97, 122-129

Wadke, D.A., Serajuddin, A.T.M., dan Jacobson, A., 1989, Preformulation Testing, dalam Lieberman, H.A., Lachman, L., dan Schwartz, J.B., (Eds), Phamaceutical Dosage Forms : Tablets, Volume 1, 2nd Ed., 55, Marcel Dekker Inc, New York.

Zin, Z.M., Hamid, A. A., Osman, A., dan Saari, N.,2004, Antioxidative Activities of Chromatographic Fractions Obtained from Root,Fruit and leaf of Mengkudu (Morinda citrifolia), Food Chem, 94, 169-178



DOI: https://doi.org/10.22146/tradmedj.8082

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