OPTIMIZATION OF LOZENGES FORMULA OF SENGGUGU ROOT BARK (Clerodendrum serratum L. Moon) EXTRACTS FOR MUCUS DILUENT (MUCOLITIC) IN COMBINATION WITH MANNITOL-LACTOSE-SUCROSE FILLERS

https://doi.org/10.22146/tradmedj.8077

T.N. Saifullah Sulaiman(1*), Desi Elvira Cindy Puspita(2), Wahyono Wahyono(3)

(1) Faculty of Pharmacy, Universitas Gadjah Mada
(2) Faculty of Pharmacy, Universitas Gadjah Mada
(3) Faculty of Pharmacy, Universitas Gadjah Mada
(*) Corresponding Author

Abstract


Senggugu root bark (Clerodendrum serratum L. Moon) is known as a mucolitics. Senggugu root bark is made in the dosage form of lozenges in combination with sucrose, mannitol and lactose in order to obtain good flavor and comfortable when consumed. The purpose of this study was to determine the effect of the combination of fillers on the physical properties of granules and tablets as well as the composition of the combination of excipients to produce lozenges of extract of senggugu root bark with optimum physical properties. Seven formulas were made with a combination of mannitol, lactose and sucrose as follows: FI (100%: 0%: 0%), FII (0%: 100%: 0%), FIII (0%: 0%: 100%), FIV (50 %: 50%: 0%), FV (50%: 0%: 50%), FVI (0%: 50%: 50%), and FVII (33.3%: 33.3%: 33.3% ). The results showed that the combination of mannitol, lactose and sucrose affected the physical properties of the granules and lozenges of extract of senggugu root bark i.e. flow rate, hardness, dissolved time, compactibility and perceptive sense. The dominant amount of sucrose and lactose can improve the physical properties of granules and tablets. The optimal composition of the combination of mannitol, lactose and sucrose obtained from Design Expert 7.1.5. program was 5.491%: 37.387%: 57.122%, respectively.


Keywords


senggugu root bark, sucrose, mannitol, lactose, optimization, lozenges, Simplex Lattice Design, Design Expert 7.1.5



References

Anonim, 1995, Farmakope Indonesia, Edisi IV, 4-5, 7, 488-489, 519, 515, Departemen Kesehatan Republik Indonesia, Jakarta

Edge, S., Kibbe, A. & Kussendrager, K., 2005, Lactose, in Rowe, R.C., Sheskey, J.P., and Weller, J.P., Handbook of Pharmaceutical Excipients 5th Ed., 385, 449, 744, The Pharmaceutical Press London

Cooper, J.W. & Gunn, C., 1975, Dispensing for Pharmaceutical Student 6th Ed, 198-200, 97-115, Pitman Medical Pubilsh Co.Ltd., London

Nugrahani, I., Rahmat, H. & Djajadisastra, J., 2005, Karakteristik Granul dan Tablet Propanolol Hidroklorida dengan Metode Granulasi Peleburan, Majalah Ilmu Kefarmasian, II (2), 106, UI Press, Jakarta

Parrot, E.L., 1970, Pharmaceutical Technology Fundamental Pharmaceutics 3rd Ed., 73-78, 82, 84, Burgess Publishing Company, Minneapolis

Pattel, J.J., Acharya, S.R., & Acharya, N.S., 2014, Clerodendrum serratul (L.) Moon. A Review on Traditional Uses, Phytochemistry and Pharmacological Activities, Journal of Ethnopharmacology, 154 (2), 268-285



DOI: https://doi.org/10.22146/tradmedj.8077

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