PHYSICAL STABILITY AND ACTIVITY OF CREAM W/O ETANOLIK FRUIT EXTRACT MAHKOTA DEWA (Phaleria macrocarph (scheff.) Boerl,) AS A SUNSCREEN

https://doi.org/10.22146/tradmedj.8041

Hidayatu Hana Shovyana(1), A. Karim Zulkarnain(2*)

(1) Faculty of Pharmacy, Universitas Gadjah Mada
(2) Faculty of Pharmacy, Universitas Gadjah Mada
(*) Corresponding Author

Abstract


Cream of Ethanolic extract Mahkota dewa fruit (Phaleria macrocarph (scheff.) Boerl,) has been reported as a sunscreen in in-vivo. The objective of this study is to evaluate the activity of sunscreen and physical stability. Determination of sunscreen was done by defining values of SPF (Sun Protection Factor) using Switzerland Weber strain mice with in vivo method. In this test we used 1 group without treatment, one negative control group (base), and 4 group treatments. Group treatment is a cream w/o ethanolic extract Mahkota dewa fruit. The value of SPF is a comparison of the DEM on the skin which were given sunscreen cream with DEM on the skin without the cream. We also did some physical stability test on the cream such as the viscosity test, spreading power, latched power, and the ratio of segregation. The Data were analyzed using SPSS to find the effect for addition of extract and prolonged storage of stability of cream. The results showed that a cream Mahkota dewa at concentration 4.6, d and 10% have an activity as a sunscreen with an SPF value of 1.25; 1.56; 2.4; and 3.05. In addition the Mahkota dewa have a good physical stability during storage.


Keywords


Mahkota dewa, cream, sun screen



References

Anonim, 1995, Farmakope Indonesia, Edisi IV, 6-7, 63, Departemen Kesehatan Republik Indonesia, Jakarta

Anief, M., 2005, Farmasetika, 117, Gadjah Mada University Press, Yogyakarta

Anonim, 2010, http://www.skin-science.com/, 25 Oktober 2011

Anonim, 2011, http://en.wikipedia.org/wiki/ sunscreen, 30 April 2011

Betageri, G. And Prabhu, S., 2002, Semisolid Preparation, dalam Swarbick, J. And Boylan, J.C., (Eds.), Encyclopedia of Pharmaceutical technology, 2nd Ed, Vol. 3, 2436, 2453-2456, Marcel Dekker Inc., New York

Djuanda, 1999, Ilmu Penyakit Kulit dan Kelamin, Edisi ke-2, 2-5, FKUI Press, Jakarta

Faried, A., Kurnia, D., Faried, L.S., Usman, N., Miyazaki, T, Kato, H., And Kuwono, H., 2007, Anticancer Effects of Gallic Acid Isolated from Indonesian Herbal Medicine, Phaleria Macrocarapa (Scheff.) Boerl, on Human Cancer Cell Lines, International Journal Of Oncology30: 605-613

Halliwel, B., and Gutteridge, J.M.C., 1999, Free Radical in Biology and Medicine, 1-231, 353-425, Oxford University Press, New York

Hardiyanto, & Soedirman, S., 1981, Gangguan Kosmetik karena Kelainan Pigmentasi Kulit, Journal of the Medical Sciences, XIII (4), 172

Harmanto, N., 2002, Mahkota Dewa Obat Pusaka Para Dewa, Cetakan IV, Agro Media Pusaka, Jakarta

Howard, G.M., 1974, Perfumes, Cosmetics, and Soap Vol III, 7th Edition, B. I. Publication, New Delhi

Koechevar, N.E., Pathak, M.A., and Parish, J.A.M., 1993, Photophysics, Photochemistry, and Ohotobiology, dalam Fitzpatrick, T.B., Eisen, A.Z., Walff, K.,Freedberg, I.M., Aisten, K.F. (Eds), Dermatology in General Medicine, 1627-1638, 4th Ed, Mc Graw-Hill, Book-Co, New York

Martin, A., Swarbick, J., & Cammarata, A., 2000, Farmasi Fisik 2, Dasar-Dasar Kimia Fisik Dalam Ilmu Farmasetik, diterjemahkan oleh Yoshita, Edisi III, 1143, 1146, 1161, Universitas Indonesia Press, Jakarta

Martini, D., Wirohadidjojo, Y.W., & Soebono, H., 1995, Potensi Tabir Surya Kombinasi Sinamat dan Benzofenon pada Berbagai Konsentrasi, Berkala Ilmu Kedokteran, 27(3), 137

Mitsui, T., 1997, New Cosmetic Science, 13,19-23, 32-36, Elsevier Science B.V., Netherlands

Mollet, H & Grubenmann, A., 2001, Formulation Technology : Emulsions, Suspensions, Solid Form, 261-262, Wiley-Vch, Toronto.

Oroh, E. &Harun, E.S., 2001, Tabir Surya (Sunscreen),Berkala Ilmu Penyakit Kulit & Kelamin, 13(1), 1

Oshimi, S., Zaima, K., Matsuno, Y., Hirasawa, Y., Lizuka, T., Studiawan, H., Indrayanto, G., Zaini, N.C., and Morita, H., 2008, Studies on The Constituents from The Fruits of Phaleria macrocarpa, J Nat Med (62):207-210

Shaat, N.A., 1990, The Chemistry of Sunscreen, dalam Lowe, N.J., Shaat, N.A., Sunscreen : Development, Evaluation, and Regulatory Aspect, (Eds.), 211-232, Marcel Derkker Inc., New York

Tambunan, R.M., dan Simanjuntak, P., 2006, Penentuan Struktur Kimia Antioksidan Benzofenon Glikosida dari Ekstrak n-Butanol Mahkota dewa, Majalah Farmasi Indonesiavol.17 (4), 184-189

Wahyuningsih, M.S.H., Mubarika, S., Gandjar, I.G., Hamann, M.T., Rao, K.V., and Wahyuono, S., 2005, Phalerin a New Benzophenoic glucoside isolated from the Methanol Extract of Mahkota Dewa [Phaleria macrocarpa (Scheff). Boerl.] Leaves, Majalah Farmasi Indonesia, 16 (1) 51-57

Wang, S.Q., Stanfield, M.S., Osterwalder, U., 2008, In Vitro Assessment of UV A Protection by Populer Sunscreen Available in the United States, J Am Dermatol 59: 934-42

Wasitaatmadja, S.M., 1997, Penuntun Ilmu Kosmetik Medik, 119-120,Universitas Indonesia Press, Jakarta

Wijanarko., Wahyuningsih M.S.H., Mubarika S., Ganjar, I.G and Wahyuono S., 2005, Aktivitas Phalerin Hasil Isolasi dari Daun Mahkota Dewa [Phaleria macrocarpa (Scheff). Boerl.] sebagai pemacu fagositosis makrofag In Vitro, Majalah Obat Tradisisonal, 10(33), 11-15

Wijanarko., Wahyuningsih M.S.H., Mubarika S., Ganjar, I.G and Wahyuono S., 2006, Aktivitas Antiradikal Phalerin Hasil Isolasi dari Daun Mahkota Dewa [Phaleria macrocarpa (Scheff). Boerl.], Majalah Obat Tradisisonal, 11(35), 16-20

Wilkinson, J.B., and Moore, R.J., 1982, The Principles and Practice of Modern Cosmetic, 7th Ed, 222, 226-228, Leonard Hill Book, London

Wolf, R., Wolf, D., Morganti, P., Ruocco, V., 2001, Sunscreen, Clinics in Dermatology, 19:252-459



DOI: https://doi.org/10.22146/tradmedj.8041

Article Metrics

Abstract views : 333 | views : 1232

Refbacks

  • There are currently no refbacks.




Copyright (c) 2013 Majalah Obat Tradisional

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

©Majalah Obat Tradisional (Trad.Med.J) 
Faculty of Pharmacy
Universitas Gadjah Mada