ANTI-INFLAMMATORY ACTIVITYY OF Piper crocatum Ruiz & Pav. LEAVES METANOLIC EXTRACT IN RATS

https://doi.org/10.22146/tradmedj.8020

Atik Fitriyani(1), Lina Winarti(2*), Siti Muslichah(3), Nuri Nuri(4)

(1) Faculty of Pharmacy, University of Jember
(2) Faculty of Pharmacy, University of Jember
(3) Faculty of Pharmacy, University of Jember
(4) Faculty of Pharmacy, University of Jember
(*) Corresponding Author

Abstract


Inflammation is a natural respon for tissue damage. To reduce inflammation, people used a NSAID (Non Steroid Antiinflammatory Drugs). This agent caused many side effects. One of medicinal plant empirically used for traditional medicine is Piper Crocatum Ruiz & Pav. This plant is potential to be developed as medicine for anti-inflammatory because its contains flavonoid, saponin, tannin, and alkaloid. The aim of this study was to investigate the anti-inflammatory effect of the P.Crocatum extract  using carrageenan-induced rat oedema test. For the anti-inflammatory activity measurement, five different groups were established and piper extract was administered  in three different doses : 25, 50 and 100 mg/kgBW. Acetosal was used as a reference agent. It was found that reduction in the flammation was 77.58% for acetosal,  72.37% for 25 mg/kg extract, 85.60% for 50mg/kg, and 81.02% mg/kg for 100mg/kg extract. Extract of P. Crocatum at 50 mg/kg showed the strongest anti-inflammatory activity among the doses used. The results showed that P. Crocatum extract posseses promising anti-inflammatory effect.


Keywords


extract P.Crocatum, anti-inflammatory effect, Acetosal



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DOI: https://doi.org/10.22146/tradmedj.8020

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