EFFECT OF KEPEL LEAVES’ EXTRACT (Stelechocarpus burahol (BL) Hook f. & Th.) CONCENTRATIONON THE ANTIOXIDANT ACTIVITY AND ITS PHYSICAL PROPERTIES WITHIN CREAM FORMULATION

https://doi.org/10.22146/tradmedj.8004

Anita Oktaviani Suwandi(1), Suwidjiyo Pramono(2), Mufrod Mufrod(3*)

(1) Faculty of Pharmacy, Universitas Gadjah Mada
(2) Faculty of Pharmacy, Universitas Gadjah Mada
(3) Faculty of Pharmacy, Universitas Gadjah Mada
(*) Corresponding Author

Abstract


This research was aimed to determine the effect of concentrations of Kepel leaves’ (Stelechocarpus burahol (BL) Hook f. & Th.)extract to antioxidant activity and physical properties of cream. Kepel leaves’ extract were made by infundation method. The antioxidant activity was tested by DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging method. Cream was made in three formulas with variation concentrations of Kepel leaves’ extract (2,5; 5,0; 7,5%b/b) using w/o basis. Physical stability parameters tested in this research were homogenity, dispersive power, adhesion, and viscosity. Data were then analyzed statistically by ANOVA One Way and Turkey Test at 95% level of significance. The results showed that concentration of Kepel leaves’ extract as an active ingredient cause different color, odor, and viscosity of the cream. The concentrationdifference of Kepel Leaves’ extract as an active ingredient was not affected the homogenity, adhesion, and the separation ratio of the cream. The difference concentration was not cause affected daya sebar cream unless the formula II (5.0% w/w) and formula III (7.5% w/w). Increasing concentration of Kepel leaves’ extract caused a different antioxidant activity unless the formula II (5.0% w/w) and formula III (7.5% w/w).


Keywords


Stelechocarpus burahol (BL) Hook f. & Th., cream, antioxidant, physical properties



References

Amarowicz, R., Naczk, M., and Shahidi, F., 2000, Antioxidant Activity of Crude Tannins of Canola and Rapeseed Hulls, JAOCS, 77, 957-961

Anonim, 1960, The United States Pharmacopeial, Ed XIV, 629, Mack Printing Company, Easton, PA

Gulcin, I., Uguz, M.T., Oktay, M., 2004, Evaluation of the Antioxidant & Antimicrobial Activities of Clary Sage (Salvia sclareaL.), Turk I. Agric. For., 28: 25-33

Mollet, H., dan Grubenmann, A., 2001, Formulation Technology Emulsions, Suspensions, Solid Forms, diterjemahkan oleh Payne, H.R., 59-62, 177, 259-262, Willey-VCH, Weinheim

Parrott, E.L., 1971, Pharmaceutical Technology : Fundamental Pharmaceuties, 3rd Ed., 365-366, Burges Publishing Company, Mineapoli.

Pujimulyani, D., 2003, Pengaruh bleanching terhadap Sifat Antioksidasi Sirup Kunir Putih (Curcuma mangga Val.), Agritech.,23 (3), 137-141

Tepe, B., Sokmen, M., Akpulkat, H.A., Sokmen, A., 2006, Screening of the antioxidant potentials of six Salvia species from Turkey, Food Chem., 95, 200-204

Sunarni, T., 2006, Isolasi dan Identifikasi Senyawa Flavonoid Antioksidan Penangkap Radikaldari Daun Kepel, Tesis, Fakultas Farmasi Pascasarjana, Universitas Gadjah Mada, Yogyakarta

Wijaya, A., 1996, Radikal Bebas dan Parameter Status Antioksidan, Forum Diagnosticum, I, 1-4

Zou, Y., Lu, Y. and Wei, D., 2004, Antioxidant activity of flavonoid – rich extract of Hypericumperforatum L in vitro, Agric. Food Chem., 52, 5032-5039



DOI: https://doi.org/10.22146/tradmedj.8004

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