THE EFFECT OF AVOCADO (Persea americana Mill.) SEED STARCH ONCENTRATION ENHANCEMENT AS A BINDER TO THE PHYSICAL CHARACTERISTICS OF THE GRANULE AND Imperata cylincrical (Linn.) ROOT EXTRACT TABLETS

https://doi.org/10.22146/tradmedj.8003

Dyah Hana Kartika(1), Mutmainah Mutmainah(2), Mufrod Mufrod(3*)

(1) Sekolah Tinggi Ilmu Farmasi “YAYASAN PHARMASI” Semarang
(2) Sekolah Tinggi Ilmu Farmasi “YAYASAN PHARMASI” Semarang
(3) Faculty of Pharmacy, Universitas Gadjah Mada
(*) Corresponding Author

Abstract


This research aims to determine the effect of avocado seed starch as a binder to the physical characteristics of the granule that is flow rate, angle of repose and moisture content as well as to the physical characteristics of tablets that is uniformity of weight, hardness, friability and disintegration time. Root of Imperata cylindrical (Linn.) extract was obtained by remaceration process usingethanol 70 % as a solvent. Tablets were made by wet granulation method with increase the avocado seed starch concentration as binder tablet (FI: 10 %, FII: 20 %, and FIII: 30 %) then the physical characteristics of granule and tablets were tested. Data were analyzed theoretically by comparing toliterature and statisticaly using one way ANOVA with a level of confidence up to  95 %,  followed by Scheffe test. The results showed that the granule’s flow rate andangle of repose decrease byincreasing of avocado seed starch concentrations as a binder, while will increase the moist content of granules. Increasing of avocado seed starch concentration as a binder will increase the hardness and disintegration time of tablets as well, while friability of tablets are decrease and weight of tablets are more uniform.

Keywords


Avocado seed starch, binders, tablets, roots of Imperata cylindra (Linn.), Physical characteristics of the granules and tablets



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DOI: https://doi.org/10.22146/tradmedj.8003

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