The Extract of Purple Sweet Potato Against Heat-Shock Protein 70 Expression in White Male Rat of Atherosclerosis Model

https://doi.org/10.22146/mot.66254

Meddy Setiawan(1*), Fitriana Yulanda(2)

(1) Department of Internal Medicine, Faculty of Medicine, University of Muhammadiyah Malang, Jl. Bendungan Sutami, No.188, Sumbersari, Lowokwaru, Malang, East Java 65145, Indonesia
(2) Department of Internal Medicine, Faculty of Medicine, University of Muhammadiyah Malang, Jl. Bendungan Sutami, No.188, Sumbersari, Lowokwaru, Malang, East Java 65145, Indonesia
(*) Corresponding Author

Abstract


Shock protein 70 (Hsp-70) molecule is pro-inflammatory mediator cytokine that trigger atherosclerosis. The purple sweet potato has many natural antioxidants such as flavonoids (anthocyanins) and is valuable for reducing Hsp-70 expression due to its antioxidant content.This study aims to determine the effect of purple sweet potato (Ipoema batatas L.) extract in reducing the Hsp-70 levels in the white male rat atherosclerosis model.This study was a posttest-only control group design with normality, homogeneity, ANOVA, post hoc test, correlation, and regression tests. There were five groups in this study. Groups 1 (negative control) and 2 (positive control) were given 2 ml/day of high-cholesterol diet for eight weeks, and the other three groups were given purple sweet potato extract at 24, 48, and 96 mg/kg doses weight per day for eight weeks. Results: The purple sweet potato extract affected the Hsp-70 levels in Wistar strain rats (p < 0.05). There was a significant difference in the Hsp-70 level between the positive control group and the group with purple sweet potato extract. The highest Hsp-70 level reduction was seen in the group with a 96 mg/day dose of purple sweet potato extract. In conclusion, theadministration of purple sweet potato extract (I. batatas L.) reduced the Hsp-70 levels. The dose of 96 mg/kg BW/day had the highest effect on decreasing Hsp-70 levels in the male rat atherosclerosis model.


Keywords


Atherosclerosis; Purple sweet potatoes extract; Heat shock protein 70

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DOI: https://doi.org/10.22146/mot.66254

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