In Vivo Antihypercholesterolemic Potential of Uncaria cordata (Lour.) Merr as Ethanolic Extract

https://doi.org/10.22146/mot.64531

Meiriza Djohari(1*), Mira Febrina(2), Tri Wahyuni(3)

(1) Sekolah Tinggi Ilmu Farmasi Riau, Jalan Kamboja, Simpang Baru Panam, 28292
(2) Sekolah Tinggi Ilmu Farmasi Riau, Jalan Kamboja, Simpang Baru Panam, 28292
(3) Sekolah Tinggi Ilmu Farmasi Riau, Jalan Kamboja, Simpang Baru Panam, 28292
(*) Corresponding Author

Abstract


The present investigation aims to evaluate the antihypercholesterolemic potential of Uncaria cordata (Lour.) Merr. as an ethanolic extract in diet-induced hypercholesterolemic male white mice model. In this study, white mice were segregated into 6 groups; all the groups except the normal control group were given a high-fat diet to induce hypercholesterolemia. After induction of cholesterolemia, normal and negative control groups were treated with NaCMC, the positive control group was treated with atorvastatin, and the remaining three groups received ethanolic extract Uncaria cordata (Lour.) Merr. in three doses (100, 200, and 400 mg/Kg BW) for a treatment period of 29 days. Measurement of cholesterol levels was performed on days 0, 15, 22, and 29 using EasyTouch® GCU digital devices. The results were analyzed by one way ANOVA test and ANOVA Repeated test. The results showed that the ethanol extract of the Uncaria cordata (Lour.) Merr. root plant dose 100, 200, and 400 mg/Kg BW effect in lowering total cholesterol in male white mice significantly (P <0,05). Ethanol extract from Uncaria cordata (Lour.) Merr. a dose of 200 mg/Kg BW showed a better decrease in cholesterol levels on day 29 compared to day 22.


Keywords


Ethanol Extract; Cholesterol; Flavonoid; Uncaria cordata (Lour.) Merr

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References

Azhari, B., Luliana, S., dan Robiyanto, 2017, Uji Aktivitas Antihiperkolesterolemia Ekstrak Air Buah Belimbing Wuluh (Averrhoa bilimbi Linn.) Pada Pemodelan Tikus Jantan Galur Wistar Hiperkolesterolemia, Traditional Medicine Journal, 22 (1):57-62.

Bertram, 2010, Farmakologi Dasar dan Klinik, 10th Edition, EGC, Jakarta.

Dahlan, M. S.m 2019, Statistik Untuk Kedokteran Dan Kesehatan. Edisi 3. ECG. Jakarta

Depkes, 2006, Pharmaceutical Care Untuk Pasien Penyakit Jantung Koroner Akut, Direktorat Bina Farmasi Klinik dan Komunitas, Jakarta.

rinanda, D., Efrizal., dan Rahayu, R, 2014, Efektivitas Gambir (Uncaria gambir Roxb.) sebagai Anti Hiperkolesterolemia dan Stabilisator Nilai Darah pada Mencit Putih (Mus musculus) Jantan, Jurnal Biologi Universitas Andalas, 3(3): 231-237.

Heizment, M. E., Neto, C. C., Winiarz, E., Vaisberg, A. J., dan Hammond, G. B, 2005, Ethnobotany, Phytochemistry and Pharmacology of Uncaria, Review Article, 66(1): 5-29.

Kemenkes, 2010, Pedoman Pemeriksaan Kimia Klinik, Menteri Kesehatan Repubik Indonesia, Jakarta

Kemenkes, 2019, Laporan Hasil Riset Kesehatan Dasar Penyakit Tidak Menular. Balitbangkes, Jakarta

Kusuma, A, M, A. M., Asarina, Y, Rahmawati, Y. I., dan Susanti, 2016, Efek Ekstrak Bawang Dayak (Eleutherine palmifolia (Lour.) Merr.) Terhadap Penurunan Kadar Kolesterol dan Trigliserida darah tikus Jantan, Jurnal Kefarmasian Indonesia, 6(2): 108-116.

Liman, H. H., dan Hartadi, C, 2002, Rhapdomiolisis Efek Samping Yang Mungkin Dijumpai pada Penggunaan Preparat Statin, Meditek, 10(27): 54-60.

Marjoni, R, 2016, Dasar-Dasar Fitokimia, CV. Trans Info Media, Jakarta.

Muhtadi., Haryanto., Sujono, T. A., Indrayudha, P., dan Suhendi, A 2013, Pengembangan Potensi Ekstrak Kulit Buah Rambutan Sebagai Bahan Obat Herbal Anthiperkolesterol, Jurnal Biomedika, 5 (2): 22-25.

Murray, R.K., Granner, D.K., Rodwell, V.W., 2009, Biokimia Harper, translated by Pendit, B.U., EGC, Jakarta.

Rocio, A., Chavez, S., Janet, A., Gutierrez, U., Sergio, O., and Serna S, 2013, Effect of Flavonoids and Saponins Extracted From Black Bean (Phaseolus vulgaris L.) Seed Coats as Cholesterol Micelle Disruptors. Plant Food Hum Nut, 68: 416-423.

Sefralisa, W, 2015, Uji Aktivitas Antiinflamasi Ekstrak Etanol Daun Tumbuhan Akar Kaik-kaik (Uncaria cordata (Lour.) Mer. pada Tikus Putih (Rattus norvegicus) Jantan. Skripsi, Sekolah Tinggi Ilmu Farmasi Riau.

Sekhon, S, 2012, Antioxidant, Anti-inflammatory and Hypolipidemic Properties of Apple Flavonol, Dalhousie University Halifax: Nova Scotia.

Sudoyo, W.A., Setiyohadi, B., Alwi, I., K, S.M., Setiati, S., 2009, Buku Ajar Ilmu Penyakit Dalam, Edisi ke-4 Jilid 3, Pusat Penerbitan Departemen Ilmu Penyakit Dalam Fakultas Kedokteran Universitas Indonesia, Jakarta Pusat.

Umami, S. R., Hapizah, S. S., Fitri, R., dan Hakim, A, 2016, Uji Penurunan Kolesterol pada Mencit Putih (Mus musculus) Secara In-Vivo Menggunakan Ekstrak Metanol Umbi Talas (Colocasia esculenta L) Sebagai Upaya Pencegahan Cardiovascular Disease, Jurnal Pijar MIPA, 11(2): 121-124.



DOI: https://doi.org/10.22146/mot.64531

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