Gel Formulation from Ethanol Extract of The Leaf of White Guava (Psidium guajava L.)
Rety Setyawaty(1*), Gustin Gustin(2), Ragil Setiyabudi(3)
(1) Pharmacy Academy of Kusuma Husada, Purwokerto, Jawa Tengah
(2) Pharmacy Academy of Kusuma Husada, Purwokerto, Jawa Tengah
(3) Muhammadyah University of Purwokerto, Purwokerto, Jawa Tengah
(*) Corresponding Author
Abstract
White guava is a plant that can grow easily in Indonesia. As a source of vitamin C, white guava leaves have been used as antidiarrheal drugs. Some studies state that white guava leaves contain antioxidants. Aside from having a selling value, white guava leaves are also used as raw materials for facial cosmetics, namely as raw materials for gel. Flavonoids are a large family of plant secondary metabolites that have various and amazing biological functions, including as antioxidants. The study aims to determine the gel preparation formulation of the white guava leaf extract (Psidium guajava L.) as a good antioxidant and the characteristics of the preparation. To extract the active substance in simplicia, maceration is used by using ethanol extract processes. The gel making uses a CMC-Na base. Formulation I uses a concentration of CMC-Na 0.1 gram. Formulation II uses a concentration of CMC-Na 0.3 grams. Formulation III uses a concentration CMC-Na 0.6 gram. The main raw material is 0.2 grams of white guava leaf ethanol extract for each formulation. The maceration process uses 70% ethanol. 250 grams of white guava leaves are used. The yield obtained was 13.92%. The gel product was analyzed organoleptic test, pH test, dispersion test, homogeneity test, and adhesion test. The results showed that the CMC-Na 0.1-grams, 0.3 grams CMC-Na, and 0.6-grams CMC-Na had a distinctive odor of white guava leaves, brownish color, and thick concentration. The gelling product is homogeneous and pH of 6. The formulations under CMC-Na 0.6 grams have good dispersibility. All formulations have good adhesion. The adhesion is more than 4 seconds. The conclusions are the formulation with CMC-Na 0.6 grams fulfills the requirements for topical gel preparation.
Keywords
Full Text:
PDFReferences
Afif K.H., 2006, Peningkatan kadar kurkumin ekstrak etanol temulawak dengan metode ekstraksi cair-cair, Skripsi. Bogor (ID): Institut Pertanian Bogor.
Alfaridz, F., 2018, Review Jurnal: Klasifikasi dan Aktivitas Farmakologi Dari Senyawa Aktif Flavonoid, Farmaka Suplemen, 16 (3): 1-9.
Ansel, H.C., 1989, Pengantar Bentuk Sediaan Farmasi, diterjemahkan oleh Farida Ibrohim, Asmanizar, Iis Aisyah, Edisi keempat, 255-271, 607-608, 700, Jakarta, UI Press.
Astuti, D.P., Husni P., and Kusdi Hartono, 2017, Formulasi dan Uji Stabilitas Fisik Sediaan Gel Antiseptik Tangan Minyak Atsiri Bunga Lavender (Lavandula angustifolia Miller), Farmaka Suplemen, Vol 15 (1): 176-184.
Garg, A, D. Aggarwal, S, Garg, and A, K, Sigla, 2002, Spreading of Semisolid Formulation: An Update.
Hamzah, M. and Mazwadehet Al, 2006, AntiInflammatory Activity ofAchillea and Ruscus Topical Gel on Carrageenan-Induced Paw Edema in Rats, Acta Poloniae Pharmaceutica - Drug Research, 63(4): 277-280.
Handayani, S. A., Purwanti, T., and Erawati, Y., 2012, Pelepasan Na-Diklofenak Sistem Niosom Span 20-Kolesterol dalam Basis Gel, PharmaScientia, Vol 1 (2): 31-43.
Indriani, S., 2006, Aktivitas Antioksidan Ekstrak Daun Jambu Biji (Psidium guajava L.). Jurnal Ilmu Pertanian Indonesia (Indonesian Journal of Agricultural Science), Vol. 11 (1), Pusat Studi Biofarmaka. IPB.
Kurnia, K A., Widyatamaka, S Q., Masyrofah, D., Prayuda, E M., and Nadia Andriani. 2020, Khasiat Daun Jambu Biji sebagai Antidiare. Health Science Growth Journal. Vol. 5 (2): 43-57.
Kusuma, T M., Azalea, M., Dianita, P S., and Naily Syifa, 2018, Pengaruh Variasi Jenis dan Konsentrasi Gelling Agent terhadap Sifat Fisik Gel Hidrokortison, Jurnal Farmasi Sains dan Praktis, Vol. IV (1): 44-49.
MOH (Ministry of Health), 2008, Farmakope Herbal Indonesia (Indonesian Herbal Pharmacopoeia), Ministry of Health Republic of Indonesia, Jakarta
Nurlaela, E., Sugihartini, N., and Ikhsanudin, A., 2012, Optimasi komposisi Tween 80 dan Span 80 sebagai emulgator dalam Repelan minyak atsiri daun Sere (Cymbopogon citratus (D.C) Stapf) terhadap nyamuk Aedes aegypti betina pada basis Vanishing Cream dengan metode Simplex Lattice Design, Pharmaciana, Vol 2(1): 41-54.
Purwandari, R., Subagiyo, S., and Teguh Wibowo, 2018, Uji Antioksidan Ekstrak Daun Jambu Biji, Walisongo Journal of Chemistry, Vol 1 (2), pp. 66-71.
Sayuti, N. A., 2015, Formulasi dan Uji Fisik Sediaan Gel Ekstrak Daun Ketepeng Cina (Cassia alata L.), Jurnal Kefarmasian Indonesia, Vol 5 (2): 74-82.
Suryani, Putri, A.E.P., and Wa Ode Hastriani Fitrih, 2015, Uji Aktivitas Antioksidan dan Stabilitas Fisik Gel Ekstrak Terpurifikasi Daun Jambu Biji (Psidium guajava L.). Pharmauho Majalah Farmasi, Sains, dan Kesehatan, Vol 1 (2): 43-48.
Ulean, Selfie P.J., Banne, Yos Suatan and Ririn A., 2012, Pembuatan Salep Jerawat dari Ekstrak Rimpang Temulawak (Curcumae xanthorrhiza Roxb), Jurnal Ilmiah Farmasi Poltekkes Manado, pp. 45-49.
Voigt, R., 1995, Buku Pelajaran Farmasi Edisi II, Yogyakarta Gajah Mada University Press, Hal 314-382.
DOI: https://doi.org/10.22146/mot.59725
Article Metrics
Abstract views : 2350 | views : 5777Refbacks
- There are currently no refbacks.
Copyright (c) 2021 Majalah Obat Tradisional
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Faculty of Pharmacy
Universitas Gadjah Mada