.png)
.png)
* Corresponding Author
Evaluation of Gastroprotective Activity of Cemot Leaves (Passiflora foetida L.) Extracted by Ultrasonic Assisted Extraction (UAE) Against Ethanol-Induced Gastric Lesions in Rats
https://doi.org/10.22146/mot.53691 Elsa Trinovita(1*), Fatmaria Fatmaria(2)
(1) Department of Pharmacology and Pharmacotherapy Faculty of Medicine Universitas Palangka Raya, Palangka Raya, Central Borneo
(2) Department of Pharmacology and Pharmacotherapy Faculty of Medicine Universitas Palangka Raya, Palangka Raya, Central Borneo
(*) Corresponding Author
Abstract
Peptic ulcers are one of the global health problems in the world. However, most of these drugs have unwanted side effects and drug interactions that this research focuses on the use of plant products as an anti gastric ulcer. The phytochemical of Passiflora foetida L. leaves or better known by the name of the Central Borneo with 'Cemot' such as flavonoids, alkaloids, and tannin has potential as a gastroprotective. This study used the method of extraction of non-conventional, namely the UAE, because it has advantages compared with other conventional methods. This study aims to investigate the gastroprotective activities of ethanol extract of Passiflora foetida leaves-UAE. Cemot extract was obtained by UAE method using a concentration of ethanol (70%), the ratio of sample/liquid (10g/mL) for 3 minutes. Three groups of rats treated with a respective dose of the extract (50, 100 and 200 mg/kg BW), one group of rats treated with omeprazole 36 mg/kg BW for seven days before peptic ulcer induction using ethanol. The activity gastroprotective with measurement of lesion of gastric ulcer index and the percentage of inhibition ulcer. Group of rats treated with 200 mg/kg BW extract showed a decreased the ulcer index and ulcer inhibition than the other extract dosage groups, respectively 2.83 and 35.34%. Conclusion: Based on the results of this study concluded that the cemot extract has potential as a gastroprotective.
Keywords
Full Text:
PDFReferences
Chan, F., K., L. & Leung, W.,K., 2002, 'Peptic-ulcer disease ', The Lancet. 360, 933–941.
Chemat, F., Rombaut, N., Sicaire, A., Meullemiestre, A. & Abert-vian, M, 2016, 'Ultrasound assisted extraction of food and natural products. Mechanism, techniques, combinations, protocols ', Ultrasonics-Sonochemistry. 34, 540–560.
Cvjetko Bubalo, M., Curko, N., Tomasevic, M., Kovacevic Ganic, K. & Radojcic Redovnikovic, I. 2016, 'Green extraction of grape skin phenolics by using deep eutectic solvents ', Food Chemistry. 200, 159–166.
Dahlan, S., 2014, ‘Statistik Untuk Kedokteran dan Kesehatan : Deskriptif, Bivariat dan Multivariat Dilengkapi Aplikasi Menggunakan SPSS Edisi 6’, Salemba Medika.
Dai, J. & Mumper, R.J, 2010, 'Plant Phenolics: Extraction, Analysis and Their Antioxidant and Anticancer Properties', Molecules.15(10), 7313–7352.
Dias, P.,C., Foglio, M.,A., Possenti, A. & de Carvalho, J.,E., 2000, 'Antiulcerogenic activity of crude hydroalcoholic extract of Rosmarinus officinalis L.', J Ethnopharmacol. 69, 57–62.
Duke, J.,A, 2009, 'Medicinal Plants of Latin America.New York', CRC Press. 501-502.
Falleh, H., Ksouri, R., Lucchessi, M. & Magne, C., 2012, 'Ultrasound-assisted extraction: Effect of extraction time and solvent power on the levels of polyphenols and antioxidant activity of Mesembryanthemum edule L. Aizoaceae Shoots', 11(2), 243–249.
Guaman-balcazar, M.,C., Setyaningsih, W., Palma, M. & Barroso, C.G., 2016. 'Ultrasound-assisted extraction of resveratrol from functional foods', Food Chemistry.103, 207-213.
Hernani, 2011, ‘Pengembangan Biofarmaka sebagai Obat Herbal untuk Kesehatan’. Buletin Teknologi Pascapanen Pertanian. 7(1). 20-29.
Jeong, K.,M., Zhao, J., Jin, Y., Heo, S. R., Han, S. Y., Yoo, D. E., & Lee, J., 2015, 'Highly efficient extraction of anthocyanins from grape skin using deep eutectic solvents as green and tunable media'. Arch Pharm Res, 38(12), 2143-52.
Katzung, B.,G., Masters, S.,B. & Trevor, A.,J, 2009. Basic & Clinical Pharmacology, 11thEd. McGraw-Hill.
Legay, M., Gondrexon, N., Person, S. E. L., Boldo, P. & Ebontemps, A, 2011. Enhancement of heat transfer by ultrasound: review and recent advances. International Journal of Chemical Engineering. 2011, 1-17.
Lim, T., K., 2012, Edible Medicinal and Non-Medicinal Plants Volume 4 Fruits, Springer. 166-172.
Mota, K., Dias, G., Pinto, M., Ferreira, A., Brito, A., Lima, C., Filho, J. & Batista, L., 2009, Flavonoids With Gastroprotective Activity, Molecules. (20), 979-1012.
Nascimento, R.,F., Sales, I., R., Formiga R., Filho, J., M., B., Sobral, M.V., Tavares, J.,F., Diniz, M., F., F., M. & Batista, L., M., 2015, Activity of Alkaloids on Peptic Ulcer: What's New?, Molecules. 20(1), 929-950.
Raji, Y., Ajani, I., Amaechi, C. & John, G., 2004. Effects of Azadirachta indica extract on gastric ulceration and acid secretion in rats. Journal of Ethnopharmacology. 90 : 167–170.
Nurhayati, T., Aryanti, D. & Nurjanah, 2009, Kajian Awal Potensi Ekstrak Spons Sebagai Antioksidan. Jurnal Kelautan Nasional. 2, 43 – 51.
Quattrocchi, U., 2012, 'CRC World Dictionary of Medicinal and Poisonous Plants Common Names, Scientific Names, Eponyms, Synonyms and, Etymology', CRC Press. 2803-2804.
Root, L., H., F., Sowndhararajan, K. & Ling, N., 2014. Antioxidant and Anti-Ulcer Effects of Ethyl Acetate Fraction. Agriculture and Agricultural Science Procedia. 2, 406–414.
Sathish, R, Sahu, Alok & Natarajan, K. 2011. Antiulcer and antioxidant activity of ethanolic extract of Passiflora foetida L. Indian Journal of Pharmacology. 43(3), 336–339.
Saputri, F.,C., Sari, P., S. & Mun’im, A., 2008. Pengembangan Metode Induksi Tukak Lambung. Majalah Ilmu Kefarmasian. V(2) : 84–90.
Strasser,M., Noriega,P., Löbenberg,R., Nádia, B. & Bacchi, E.,M, 2014, Antiulcerogenic Potential Activity of Free and Nanoencapsulated Passiflora serratodigitata L. Extracts. BioMed Research International, 1-7.Srikanta, B.,M., Siddaraju, M.,N. & Dharmesh, S.,M., 2007, A novel phenol-bound pectic polysaccharide from Decalepis hamiltonii with multi-step ulcer preventive activity. World Journal of Gastroenterology. 13 (39), 5196–5207.
Sheen, E., Triadafilopoulos, G. 2011. Adverse effects of long-term proton pump inhibitor therapy. Digestive Diseases and Sciences. 56, 931–950.
Suzuki, Y., Hayashi, M., Ito, M., Yamagami, I. 1976. Anti-ulcer effects of 40-(2-carboxyethyl) phenyl trans-4-aminomethyl cyclohexane carboxylate hydrochloride (Cetraxate) on various experimental gastric ulcers in rats. Japanese Journal of Pharmacology. 26, 471–480
Trinovita, E., Saputri, F.,C. & Mun'im, A., 2018, Potential Gastroprotective Activity of Rice Bran (Oryza sativa L.) Extracted by Ionic Liquid-Microwave-Assisted Extraction against Ethanol-Induced Acute Gastric Ulcers in Rat Model, Sci. Pharm. 86(3), 35
Zelickson, M.,S., Bronder C.,M., Johnson B.,L., Camunas J.,A., Smith D.,E., Rawlinson D., Von, S., Stone, H.,H. & Taylor S.,M., 2011. Helicobacter pylori is not the predominant etiology for peptic ulcers requiring operation. The American Surgeon Journal. 77, 1054-1060.
Wijaya, W., Trinovita E., Carmelita, A.,B., 2018. Uji Aktivitas Berbagai Konsentrasi Ekstrak Etanol Daun Cemot (Passiflora foetida) dengan Metode Dilusi Cair Sesudah Inkubasi Pada Pertumbuhan Salmonella typhi. Proceeding Book The 1st National Symposium Medical Faculty of Palangka Raya University, 123-135.
DOI: https://doi.org/10.22146/mot.53691
Article Metrics
Abstract views : 2368
| 
views : 2687
Refbacks
- There are currently no refbacks.
Copyright (c) 2020 Majalah Obat Tradisional
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Faculty of Pharmacy
Universitas Gadjah Mada