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* Corresponding Author
A Review of Component and Pharmacology Activities of Black Garlic
https://doi.org/10.22146/mot.45277 Novitaria Br Sembiring(1*), Yoppi Iskandar(2)
(1) 1) Master Program of Pharmacy, Faculty of Pharmacy, Universitas Padjajaran, Sumedang 2) Department of Biology Pharmacy, Faculty of Pharmacy, Universitas Padjajaran, Sumedang, Indonesia
(2) Department of Biology Pharmacy, Faculty of Pharmacy, Universitas Padjajaran, Sumedang, Indonesia
(*) Corresponding Author
Abstract
Black garlic is garlic fermented in high temperature and humidity, and the fermentation compound chemical in garlic changes to new chemicals, such as S-allyl cysteine (SAC), S-allylmercapto-cysteine, and arginine. The color changed to dark brown during the aging period because of the Maillard reaction, known as non-enzymatic browning reaction. Black garlic has 57.14% of fructose, 6.78% of glucose, and 7.62% of sucrose, which were mainly saccharides in black garlic to answer for its sweet taste. It is such a pharmacological activity which contains antioxidant, anti-cancer, hepatoprotective, can improve the immune system, reduce hyperglycemia, dyslipidemia, and anti-allergic. We summarize the current knowledge of a change in the components, bioactivity, production, and applications of black garlic, as well as the proposed future prospects on their possible applications as a functional pharmacy product.
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Belloir, C., Singh, V., Daurat, C., Siess, M. H. & Le Bon, A. M. 2006. Protective effects of garlic sulfur compounds against DNA damage induced by direct- and indirect-acting genotoxic agents in HepG2 cells. Food Chem. Toxicol. 44, 827–834.
Dong.M., Guiqing. Y., Hanchen. L., Xiaoxu. L., Sixiang. L., Dongnung. S. & Yishan. W. “Aged Black Garlic Extract Inhibits HT29 Colon Cancer Cell Growth via the PI3K/Akt Signaling Pathway”. Biomedical Reports, vol. 2, no. 2, 2014, pp. 250–54.
Jeong, Y.Y., Ji, H.Y., Jung-Hye. S., Min, J.K., Jae, R.K., Jaehee, H. & Dawon, K. 2016. Comparison of Anti-Oxidant and Anti-Inflammatory Effects between Fresh and Aged Black Garlic Extracts. Molecules, 21: 1-15.
Kim, J. H., Nam, S. H., Rico, C. W. & Kang, M. Y. 2012. A comparative study on the antioxidative and anti-allergic activities of fresh and aged black garlic extracts. Int. J. Food Sci. Technol,47, 1176–1182.
Kim, M.H., Min, J.K., Jeung, H.L., Jang, I.H., Jin, H.K., Dai-Eun, S. & Mee, R.K. 2011. Hepatoprotective Effect of Aged Black Garlic on Chronic Alcohol-Induced Liver Injury in Rats. Journal Of Medicinal Food, 14:732-738.
Kim, M. J. Yoo, Y.C., Hyun, J.K., Suk, K.S., Eun, J.S., A-Young, M., Nak, Y.S., and Mee, R.K. 2014. Aged black garlic exerts anti-inflammatory effects by decreasing NO and proinflammatory cytokine production with less cytoxicity in LPS-stimulated RAW 264.7 macrophages and LPS-induced septicemia mice. J. Med. Food. 17, 1057–1063.
Lee, Y.M., Gweon, O.C., Seo, Y.J., Im, J., Kang, M.J., Kim, M.J., and Kim, I. K. 2009. Antioxidant effect of garlic and aged black garlic in animal model of type 2 diabetes melitus. Nutrition Research and Practice, 3, 156-161.
Liang. T., Wei. F., Lu. Y., & Kodani. Y. 2015. Comprehensive NMR analysis of compositional changes of black garlic during thermal processing. J Agric Food Chem, 63: 683-691.
Lu, X., Li, N., Qiao, X., Qiu, Z. and Liu, P. 2017. Composition analysis and antioxidant properties of black garlic extract. J. Food Drug Anal. 25, 340–349.
Moelyono MW. Etnofarmasi. Deepublish, Yogyakarta, 2014, pp. 42, 149, 156, 163.
Nagaoka, I., Kaori, S., Taisuke, M., Francois, N., Hirosi, T and Michimasa, H. “Evaluation of the Effect of Alpha Defensin Human Neutrophil Peptides on Neutrophil Apoptosis”. International Journal of Molecular Medicine, vol. 23, no. 4, 2009, pp. 521–27.
Park. C., Sejin. P., Yoon. H.C., Gi-Young. K., Young. W.C., Byung. W.K. and Yung. H.Y. 2014. Induction of Apoptosis by a Hexane Extract of Aged Black Garlic in the Human Leukemic U937 Cells”. Nutrition Research and Practice. 8 (2), 132–37.
Qian, Y., Corum, L., Meng, Q., Blenis, J., Zheng, J,Z, Shi, X., Flynn, D,C., and Jiang, B.H. 2004. PI3K induced actin filament remodeling through Akt and p70S6K1: Implication of essential role in cell migration. Am. J. Physiol. - Cell Physiol., 286, 153–163.
Sasaki, J., Chao, L., Machiya, E., Takahashi, M. & Hamada, K. 2007. Processed Black Garlic (Allium sativum) Extracts Enhance Anti-Tumor Potency against Mouse Tumors. Glob. Sci, 2007, Books 4–7.
Seo. Y-J., Oh-Cheon. G., Jieun. I., Young-Min. L., Min-Jung. K. & Jung-In. K. 2009. Effect of Garlic and Aged Black Garlic on Hyperglycemia and Dyslipidemia in Animal Model of Type 2 Diabetes Melitus. J Food Sci Nutr.14:1-7.
Sook, Cha, H. S. and Lee, Y. S. 2014. Physicochemical and antioxidant properties of black garlic. Molecules. 19, 16811–16823.
Tran, G. B., Dam, S. M. and Le, N. T. T. Amelioration of Single Clove Black Garlic Aqueous Extract on Dyslipidemia and Hepatitis in Chronic Carbon Tetrachloride Intoxicated Swiss Albino Mice. Int. J. Hepatol, 2018.
Wang, D., Yonghui, F., Jun, L., Jianzhong, Y., Meiru, W., Jin-ichi & Changlong, L. 2010. Black Garlic (Allium sativum) Extracts Enhance the Immune System. Medicinal and Aromatic Plant Science and Biotechnology 4(1), 37-40.
Wang, X., Fei, J., Qin-Wen, W., Juan, W., Ke-Yang., Rong-Rong, H., Han-Chen, L., Hong-Yang, W., and Yi-Shan, W. 2012. Aged Black Garlic Extract Induces Inhibition of Gastric Cancer Cell Growth in Vitro and in Vivo. Molecular Medicine Reports 5 (1), 66–72.
Zhang, Z., Mengmeng, L., Rui, L., Yunfeng, G., Mengying, X. and Min, Z. 2015. Evaluation Of Alliin, Saccharide Contents and Antioxidant Activities Of Black Garlic During Thermal Processing. Journal of Food Biochemistry.P:1-9.
DOI: https://doi.org/10.22146/mot.45277
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