Utilization of Artocarpus heterophylla Lamk. As UV Protector In mice exposed to UV-B

https://doi.org/10.22146/mot.37407

Ketut Agus Adrianta(1*), I Made Agus Sunadi Putra(2)

(1) Akademi Farmasi Saraswati Denpasar, Bali
(2) Akademi Farmasi Saraswati Denpasar, Bali
(*) Corresponding Author

Abstract


In daily life, Artocarpus heterophylla Lamk., the leaves are rarely used even just as animal feed. In the bark of Artocarpus heterophylla Lamk there are new flavonoid compounds namely morusin, artokarpin, artonin E, cycloartobilosantone, and artonol B. This research is an experimental design with randomized posttest only with control group design. A total of 21 mice were divided into 3 groups, each consisting of 7 mice, group 1: negative control given oral placebo and exposed to UV-B rays, group 2:giving Vitamin C cream 4% mg and exposed to UV-B rays, group 3: giving cream of Artocarpus heterophylla Lamk leaf extract 4% and exposed to UV-B rays. The total of UV radiation dose of 600 mJ / cm² for 3 weeks, then performed a biopsy for examination of the amount of dermis collagen. The average number of collagen in the three groups after treatment was given significantly different (p <0.05). Mean and Significant level of collagen density of group 1 : 51,42 ± 5,16; group P2 ± 91,18 ± 1,13; and P3 group: 88,77 ± 1,10. Conclusion : Cream of 4% Artocarpus heterophylla Lamk leaf extract can increase the amount of collagen density in mice exposed to UV-B rays.

Keywords


Artocarpus heterophylla Lamk; artokarpin; uv-protector; collagen

Full Text:

PDF


References

Almatsier,  Sunita.  2004. Prinsip  Dasar  Ilmu  Gizi. Jakarta : PT. Gramedia Pustaka Utama.

Ersam, T. 2001. Senyawa Kimia Makromolekul Beberapa Tumbuhan Artocarpus HutanTropika Sumatera Barat, (Disertasi). Bandung : ITB.

Federer, W. T. 2011. Statistical Design and Analysis for Intercropping Experiments. New York : Springer. p 30-33.

Fisher, G. J., Kang S., Varani, J., Bata-Csorgo, Z., Wan, Y., Datta, S., and Voorhees, J. J. 2002. Mechanisms of Photoaging and Chronological Skin Aging. Arch Dermatology. 138:1462-70.

Gonzaga, E.R. 2009. Role of UV Light in Photodamage, Skin Aging, and Skin Cancer. Importance of Photoprotection. Am J Clin Dermatol. 10 (1): 19-24.

Helfrich, Y.R., Sachs, D. L., and Voorhees, J. J. 2009. The Biology of Skin Ageing. European Dermatology. 39-42.

Kadler, K. E., Holmes, D. F., Trotter, J. A., & Chapman, J. A. 1996. No Title Collagen fibril formation. Biochemical Journal, 316, 1.

Marczyk., Geoffrey, R.,  Dematteo, D.,    Festinger,   D.

2005. Experimental design. In: Dematteo, D., David., editors. Essential of Research Design and Methodology. First edition. New Jersey : John-Wiley. p 48-56.

Nichols, J.A., Katiyar, S.K. 2010. Skin Photoprotection by Natural Polyphenols: Antiinflammatory, Anti-oxidant and DNA repair mechanisms. Arch Dermatol Res. 302(2): 71.

Rukmana, R. 1997. Nangka Budidaya dan Pasca panen. Yogyakarta : Kanisius.

Sauermann, K., Jaspers, S., Koop, U., and Wenek, H. 2004. Topically Applied Vitamin C Increases The Density of Dermal Papillae in Aged Human Skin. BMC Dermatology. 4:13.

Scott, D., Bennion, M. S. 2011. Structure and Function of The Skin. In: Fitzpatrick, J. E., Morelli, J. G., editors. Dermatology Secret Plus. Fourth edition. Philadelphia : Elsevier Mosby. P 6-13.

Soeratri, W., Hadinoto, I.,  &  Anastasia, T. Penentuan Nilai SPF In Vitro Sediaan Krim  Tabir  Surya  Matahari  Etilheksil-p-metoksisinamat  dan  Oksibenson. Majalah Farmasi Airlangga.

Varani, et al., 2001. Inhibition of Type I Procollagen Synthesis by Damage Collagen in Photoaged Skin and by Collagenase-Degraded Collagen in Vitro. The Journal of Pathology. 158(3): 931-42.

Wilkinson, J.B. 1982. Harry's Cosmeticology 7th Edition. London : George Godwin.

Yulia. 2009. Penentuan Komposisi Optimal Kombinasi Sulisobenzon dan Dietilamino Hidroksibenzoil Heksil Benzoat dalam Sediaan Krim Tabir Surya. Bandung : Universitas Jenderal Achmad Yan.


 

 



DOI: https://doi.org/10.22146/mot.37407

Article Metrics

Abstract views : 85 | views : 104

Refbacks

  • There are currently no refbacks.




Copyright (c) 2018 Majalah Obat Tradisional (Traditional Medicine Journal)

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

©Majalah Obat Tradisional (Trad.Med.J) 
Faculty of Pharmacy
Universitas Gadjah Mada