Optimizing Formula of Fast Disintegrating Tablet of Belimbing Wuluh Leaf Extract with Crospovidone and Croscarmellose Sodium as Superdisintegrant


Citra Ariani Edityaningrum(1*), Tantri Sofia Fauziah(2), Zainab Zainab(3), Hardi Astuti Witasari(4)

(1) Faculty of Pharmacy, Ahmad Dahlan University
(2) Faculty of Pharmacy, Ahmad Dahlan University
(3) Faculty of Pharmacy, Ahmad Dahlan University
(4) Faculty of Pharmacy, Ahmad Dahlan University
(*) Corresponding Author


Averrhoa bilimbi L. leaves can be used as an antidiabetic in the presence of flavonoid. Antidiabetic drugs were widely consumed by elderly patients who often had difficulty in consuming conventional tablets. Research in developing formulations of an antidiabetic drug that is capable of rapid disintegration and quickly dissolves when placed on the tounge is necessary, therefore it is formulated in fast disintegrating tablet dosage forms. The research aimed to formulate FDT of ethanol extract of Averrhoa bilimbi L. leaves with variation of superdisintegrant crospovidone and croscarmellose sodium. Fast disintegrating tablet of Averrhoa bilimbi L. leaves extract was manufactured by direct compression. Furthermore, the tablet was evaluated with physical properties and the results were analyzed using Design expert 10.1.3 program to bring in simplex lattice design (SLD) equation to get the optimum formula. Data which had been obtained was then analyzed byone sample test with confidence interval 95%. Based on the research results, the combinations of crospovidone and croscarmellose sodium was able to reduce the response of physical properties such as weight variation, hardness, friability, disintegration time, and wetting time. The optimum formula consist of 6.8 mg crospovidone and 12.2 mg croscarmellose sodium which resulted in 4.41 kg of hardness response, 0.59% of friability, 11.21 seconds of wetting time, and 3,85 seconds of disintegration time. Analysis of one sample t-test showed that there was no significant difference between the parameter values predicted results with the results of the research, so it can be concluded that SLD equation can be used to develop a formula that gives optimum parameters of FDT.


ekstrak daun belimbing wuluh (Averrhoa bilimbi L.); fast disintegrating tablet; crospovidone; croscarmellose sodium; fast disintegrating tablet; crospovidone; croscarmellose sodium

Full Text:



Allen, L., V., Popovisch, N.G. dan Ansel, H.C., 2011, Ansel’s Dossage Forms and Drug Delivery Systems, 9th Ed., Lippinkott Williams and Wilkins, Philadelphia.

Anonim, 1979, Farmakope Indonesia Edisi III, 5-6, Departemen Kesehatan Republik Indonesia, Jakarta.

Balasubrmaniam, J. 2009, ‘Influence of Superdisintegrants on The Rate of Drug Dissolution from Oral Solid Dosage Forms’, Pharmaceutical Technology, April.

Bhowmik, D., Chiranjib, B., Krishnakanth, Pankaj, dan Chandira, R.M., 2009, ‘Fast Dissolving Tablet: An Overview’, JoCPR, 2009, 1(1), 163-177.

Brahmachari, G., 2011, ‘Bio-Flavonoids With Promising Antidiabetic Potensials: A Critical Survey’, Research Signpost, 187-212.

Chatap, V.K., Marathe, G.M., Maurya, A.R, dan Patil, N.D., 2013, ‘Formulation and Evaluation of Zaltoprofen Fast Disintegrating Tablet’, J. PharmaSciTech., 3(1), 20.

Department of Health, 2009, British Pharmacopoiea, The Departement of Health, London.

Diniatik, 2016, ‘Potensi Penangkapan Radikal Bebas Hasil Hidrolisis Ekstrak Etanol Daun Kepel (Stelechocarpus Burahol, (Bl.) Hook F. & Th.) dengan Metode DPPH’, Media Farmasi, 13(2), 258.

Giri, K.T., Jana, P., dan Sa, B., 2008, ‘Rapidly disintegrating fast release tablets of diazepam using solid dispersion: development and evaluation’, J. Sci. and Indust. Res., 67, 436-439.

HyunhBa, K., 2008, Handbook of Stability Testing in Pharmaceutical Development, Springer, New York.

Irawan, W., dan Sulaiman, T.N.S., 2016, ‘Optimasi Formula Fast Disintegrating Tablet Natrium Diklofenak Terinklusi Β-Siklodekstrin dengan Superdisintegrant Crospovidone dan Filler Binder Mikrokristalin Selulosa Ph 102’, Majalah Farmaseutik, 12(2), 443-452.

Jain, C.P. dan Naruka, P.S., 2009, ‘Formulation and Evaluation of Fast Dissolving Tablets of Valsartan’, International Journal of Pharmacy and Pharmaceutical Sciences, 1, 219-221.

Kibbe, A.H., 2009, Crospovidone, dalam Rowe, R.C, Sheskey, P.J., Quinn, M.E., (Eds.), Handbook of Pharmaceutical Excipients, 6th Edition, 208-209, Pharmaceutical Press and American Pharmacists Association, USA.

Kumar, G. P. and Nirmala, R. 2012, ‘Fundamental Aspects of Superdisintegrants: a Concise Review’, Journal of Global Pharma Technology, 4 (2), 1-12.

Mothilal, M., Kota, S., Babu, S.G., Kumar, G., Manimaran, V., Damodharan, N., 2012, ‘Formulation and Evaluation of Rizatripan Benzoate Orally Disintegrating Tablets’, Int. J.Drug Dev. and Res., 4(2), 117-123

Panigrahi, R., dan Behera, S., 2010, ‘A review on Fast Dissolving Tablets’, Webmed Central Quality and Pasien Safety, 1(9).

Puspharaj, P.N., 2004, Evaluation of the Anti-diabetic Properties of Averrhoa bilimbi in Animal with Experimental Diabetes, National University of Singapore, Singapore.

Sulaiman, T.N.S., 2007, Teknologi dan Formulasi Sediaan Tablet, Edisi I, Pustaka Laboratorium Teknologi Farmasi UGM, Yogyakarta.

Torne, S., Sakarkar, D.M., Pawar, S.R., & Abdul, R., 2010, ‘Fast Disintegrating Tablets of Ondansentron Hydrochlride by Direct Compression Technique’, Int. J.Pharm. Tech. Res., 2(1), 433-437.

DOI: https://doi.org/10.22146/mot.32002

Article Metrics

Abstract views : 4006 | views : 11084


Copyright (c) 2018 Majalah Obat Tradisional

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

©Majalah Obat Tradisional (Traditional Medicine Journal)
 ISSN 2406-9086
Faculty of Pharmacy
Universitas Gadjah Mada