Capsule Formulation of Ethanolic Extract of Pasak Bumi (Eurycoma Longifolia Jack.,) and its Effect on Human Health Vital Signs

https://doi.org/10.22146/tradmedj.27919

Laela Hayu Nurani(1*), Eka Kumalasari(2), Abdul Rohman(3), Sitarina Widyarini(4)

(1) Faculty of Pharmacy, Ahmad Dahlan University, Yogakarta
(2) Faculty of Pharmacy, Ahmad Dahlan University, Yogyakarta
(3) Faculty of Pharmacy, Universitas Gadjah Mada
(4) Faculty of Veterinary Medicine, Universitas Gadjah Mada, Yogyakarta
(*) Corresponding Author

Abstract


Pasak bumi (Eurycoma longifolia) has the potential to be developed as antihypertensive, antipyretic, aphrodisiacs and health supplements. The use of E. longifolia as a traditional medicine needs to be pursued in the form of more effective and appropriate formulation. The capsule preparations are easy to make and can
cover the bitter taste of E. longifolia. Clinical trials in this study use design pre-post treatment in healthy humans. Subjects used were male - healthy men and healthy women who met inclusion criteria and were subjected with formulated capsule for 14 days. The study resulted capsule formula comprising of the ethanolic extract of E. longifolia 300 mg, vivapur 101 300 mg, 58 mg maydis starch, aerosil 3%, talc 2%, and Mg stearate 1%. The results showed that the capsule of E. longifolia did not affect the value of heart rate, respiration rate, body temperature and weight (P > 0.05), based on paired t-test, but they causes a decrease in blood pressure of healthy human. The ethanol extract of E. longifolia caused vasodilation of blood vessels that can be used in antihypertensive therapy.


Keywords


Akar pasak bumi; kapsul; Eurycoma longifolia; capsules; vital sign

Full Text:

PDF


References

Ahmad, N.S., Nazrun, S., Mohd, F.A.B., Tajul, A.BS., Norliza M., Norazlina M., & Ima NS., 2011. The anti-osteoporotic effect of Eurycoma Longifolia in aged orchidectomised rat mode. Aging Male 14(3): 150–154.

Ariff, A.S.T., Ima, N.S., Pramanik., J., & Ahmad, N.S., 2012. Effects of Eurycoma longifolia on Testosterone Level and Bone Structure in an Aged Orchidectomised Rat Model. Evidence-Based Complementary and Alternative Medicine, Article ID 818072, 7 pages

Augsburger, L.L., 2000. Modern Pharmaceutics: Hard and Soft Gelatin Capsules, (2nd Ed.), New York: Mercel Dekker.

Bedir, E., Gazar, H., A., Ngwendson, J., N., & Khan, I., A., 2003, Eurycomaoside: A New Quassinoid-Type Glycoside from the Roots of Eurycoma longifolia. Chemical and Pharmaceutical Bulletin 51: 1301-1303.

Dewoto, H.R., 2007, Pengembangan Obat Tradisional Indonesia Menjadi Fitofarmaka. Majalah Kedokteran Indonesia 57: 7-11.

Eng, A,. 2007. Correcting systemic androgen levels using Eurycoma longifolia. U.S. Patent Application 11/176,464, filed July 7, 2005, U.S. patent 20070009621.

Hayati, F., 2013,. Uji Praklinik dan Uji Klinik Fase I Ekstrak Air Akar Pasak Bumi (Eurycoma longifolia Jack) Terstandar sebagai Afrodisiaka, Disertasi, Fakultas Kedokteran Universitas Gadjah Mada, Yogyakarta.

Henkel, R. R., et al, 2013. Tongkat Ali as a Potential Herbal Supplement for Physically Active Male and Female Seniors-A Pilot Study. Phytotherapy Research 28(4): 44-50.

Kearney, P.M., Whelton, M., Reynolds, K., Muntner, P., Whelton, P.K., & He, J. 2005, Global burden of hypertension: analysis of worldwide data. Lancet 2005; 365: 217–23.

Malkin, C.J., Jones, R.D., Jones, T.H., Channer, K.S., 2006. Effect of testosterone on ex vivo vascular reactivity in man. Clinical Sciences 111: 265-74.

Minorsky, P.V, 2004. On the inside. Plant Physiology 131(3):1157-1158.

Mokhtar, R.H., Abdullah, N., & Ayob A., 2014. Effects of Eurycoma Longifolia Extract on the Isolated Rat Heart. The international Medical Journal Malaysia 13: 1-10.

Muffichatum, 2006. Hubungan antara Tekanan Panas, Denyut Nadi dan Produktivitas Kerja pada pekerja Pandai Besi Paguyuban Wesi Aji Dororejo Batang. http://digilib.unnes.ac.id. Diakses pada tanggal 12 Agustus 2016

Muhamad, AZ., Keong, C.C., Kiew, O.F., Abdullah., M.R., Lam., C.K., 2010. Effects of Eurycoma longifolia Jack supplementation on recreational athletes’ endurance running capacity and physiological responses in the heat. International Journal of Applied Sports Sciences 22(2): 1-19.

Novianti, S, 2015. Pemberian ekstrak etanol akar pasak bumi secara oral meningkatkan kadar hormon testosterone tikus wistar jantan tua, Tesis, Program Pasca Sarjana Universitas Udayana, Denpasar, Bali.

Pugh, P.J., Jones, R.D., Jones, T.H., Channer, K.S., 2002. Intrinsic response of rat coronary arteries in vitro. Endocrine 19: 155-61.

Roselyndiar, 2012, Formulasi Kapsul Kombinasi Ekstrak Herba Seledri (Apium graveolens L.) dan Daun Tempuyung (Sonchus arvensis L.), Skripsi, Fakultas MIPA, Universitas Indonesia Schriger, D.L., 2007, Approach to the patient with abnormal vital signs. Goldman L, Ausiello D. Cecil Textbook of Medicine. 23rd Ed. Philadelphia, USA: Elsevier.

Tee, B.H., Hoe, S.Z., Cheah, S.H., Lam, S.K., 2016, First Report of Eurycoma longifolia Jack Root Extract CausingRelaxation of Aortic Rings in Rats. BioMed Research International Volume 2016, Article ID 1361508, 9 pages.

Udani, J.K., Annie, A.G., Mufiza, M., Michael, N.P., Azreena, A., 2013. Effects of a Proprietary Freeze-Dried Water Extract of Eurycoma longifolia (Physta) and Polygonum minus on Sexual Performance and Well-Being in Men: A Randomized, Double-Blind, Placebo-Controlled Study. Evidence-Based Complementary and Alternative Medicine, Article ID 179529, 10 pages.



DOI: https://doi.org/10.22146/tradmedj.27919

Article Metrics

Abstract views : 1102 | views : 4882

Refbacks

  • There are currently no refbacks.




Copyright (c) 2017 Majalah Obat Tradisional (Traditional Medicine Journal)

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

©Majalah Obat Tradisional (Trad.Med.J) 
Faculty of Pharmacy
Universitas Gadjah Mada