THE COMBINATION OF MANGOSTEEN PEEL EXTRACT WITH ROSELLA FLOWER PETALS EXTRACT AND ANTHILL PLANT EXTRACT AS CHOLESTEROL AND TRIGLYCERIDES REDUCER ON MALE WHITE RATS

https://doi.org/10.22146/tradmedj.17304

Anjar Mahardian Kusuma(1*), Erza Genatrika(2), Rossy Faizah Nur Utami(3), Trisna Rohmiyati(4), Susanti Susanti(5)

(1) Faculty of Pharmacy, Universitas Muhammadiyah Purwokerto
(2) Faculty of Pharmacy, Universitas Muhammadiyah Purwokerto
(3) Faculty of Pharmacy, Universitas Muhammadiyah Purwokerto
(4) Faculty of Pharmacy, Universitas Muhammadiyah Purwokerto
(5) Faculty of Pharmacy, Universitas Muhammadiyah Purwokerto
(*) Corresponding Author

Abstract


Hypercholesterolemia is a disease associated with high levels of cholesterol and LDL levels in the blood. Utilization of the commercial drugs can be given; however apart from the expensive price, adverse side effects might occur. It makes people choose alternative medication with herbal medicine through the use of natural materials. This study aimed to determine the effect of the combination of mangosteen peel extract-extract of roselle calyx and mangosteen peel extract-extract the ant nest plant as lowering cholesterol and triglyceride levels in male rats. The method used in this study was a laboratory experimental method using device posttest only control group design (simple experimental design). This study used 25 male rats of Wistar strain, divided into 5 groups; Group I: group without treatment, group II: control group solvent (NaCMC 1%), group III: positive control group (Simvastatin), Group IV: combination group mangosteen peel extract (200 mg / kg) - extract of roselle calyx (250 mg / kg), group V: group combination of mangosteen peel extract 200 mg / kg) - extract anthill (270 mg / kg). Induction of cholesterol in rats using quail egg yolk (10 ml / kg). The results showed that there was no significant difference in cholesterol and triglycerides between the combination of both extracts of mangosteen peel with a positive control (p<0,05).

Keywords


cholesterol, combination, mangosteen, rosella, ant nest plant



References

Anonim., 2010, Riset Kesehatan Dasar 2010, Jakarta: Badan Litbangkes Kemenkes RI.

Arief, M.I., R. Novriansyah, I.T. Budianto dan M.B Haryaji, 2012, Potensi Bunga Karumunting (Melastoma malabathricum) terhadap kadar kolesterol total dan trigliserida pada tikus jantan hiperlipid yang diinduksi propiltiourasil. 1(2): 118-126.

Adiputro, Dwi, L., Widodo, M.Aris, Romdoni, R., dan Sargowo, Djunggan, 2013, Ekstract of mangosteen increases high density lipoprotein levels in rats fed high lipid, Malang, Faculty of Medicine, Brawijaya.

Budiyono, Wahyu, 2012, Perbedaan kadar kolesterol total dan trigliserida sebelum dan setelkah pemberian sari daun cincau hijau (Premna oblongifolia Merr.) pada tikus dislipidemia, Semarang, Fakultas Kedokteran, Universitas Diponegoro.

Christianto., A.N., 2012, Aktivitas Hipokolesterolimik Ekstrak Rosella (Hibiscus sabdariffa L)Pada Tikus Putih Diabetes. Madiun: Universitas Katolik Widya Mandala.

Cristyana, To Lidwina Prillya Indra, 2014, Pengaruh pemberian ekstrak kulit manggis (Garcinia mangostana L.) dan simvastatin terhadap kadar kolesterol LDL tikus sprague-dawley dengan pakan tinggi lemak, Semarang, Fakultas Kedokteran, Uneversitas Diponegoro.

Dinayanti, T., 2010, Pengaruh Pemberian Seduhan Kelopak Bunga Rosella (Hibiscus sabdariffa) Terhadap Kadar Kolesterol Total Serum Tikus Sprague-Dawley hiperkolesterolemik [Skripsi].Semarang; Universitas Diponegoro; 2010

Khairuddin, Mangau, Marianti A., Mufidah, 2012, Uji Efek Ekstrak Etanol Sarang Semut (Hydnophytum sp.) terhadap perubahan bobot tubuh mencit (Mus muculus), Makasar,Majalah Farmasi dan Farmakologi, Vol. 16, No 1, Maret 2012

Mutschler, E. 1999, Dinamika Obat, Ed. V, cetakan ketiga. Bandung: ITB Press.

Noorya, Maya Lakshita, 2013, Efektivitas Ekstrak Etanol Batang Sarang Semut (Hydnophytum formicarum) terhadap kadar LDL (Loe Density Lipoprotein) Tikus (Rattus norvegicus) Diabetes terinduksi Alloxan, [Abstrak], Yogyakarta, Fakultas Kedokteran dan Ilmu Kesehatan, Universitas Muhammadiyah Yogyakarta.

Putra, Muhammad Nadhil S., 2014, Pengaruh Pemberian Ekstrak Kulit Manggis (Garcinia mangostana L.) dan Simvastatin terhadap Kadar Kolesterol total Tikus Sprague Dawley dengan pakan Tinggi Lemak, Semarang, Fakultas Kedokteran, Universitas Diponegoro.

Raihan, Md.S., Moazzem, S.M.H., Sariful, Md.I.H., Ashfaqure, Md.R., Avijit, D., 2012, Anti-diarrheal, Analgesic, and Anti-mivrobial activites of the plant Lalmesta (Hibiscus sabdariffa): A review, International Journal of Pharmaceutical and Life Science. ISSN 2305-0330, Vol. 2, Issue 3, Serial 3, November 2012.

Suckow MA, Weisbroth SH, Franklin CL. 2005, The Laboratory Rats. Academic Press.

Wahyuni, A., 2009, Metabolisme kolesterol hati : Khasiat Ramuan Jati Belanda (Guazuma ulmifolia Lamk) dalam mengatur konsentrasi selular, [Skripsi], Bogor, Fakultas MIPA, Institus Pertanian Bogor. 2009

Yang, M. Y., Peng, C. H., Chan, K. C., Yang, Y. S., Huang, C. N., & Wang, C. J. The Hypolipidemic Effect of Hibiscus sabdariffa Polyphenols Via Inhibiting Lipogenesis and Promoting Hepatic Lipid Clearance. Journal of Agricultural and Food Chemistry. 2010; 58(2):850–9



DOI: https://doi.org/10.22146/tradmedj.17304

Article Metrics

Abstract views : 1099 | views : 3252

Refbacks

  • There are currently no refbacks.




Copyright (c) 2016 Majalah Obat Tradisional

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

©Majalah Obat Tradisional (Trad.Med.J) 
Faculty of Pharmacy
Universitas Gadjah Mada