ANALGESIC ACTIVITY STUDY OF ETHANOLIC EXTRACT OF Callicarpa longifolia Lamk. IN MICE

https://doi.org/10.22146/tradmedj.12824

Eka Siswanto Syamsul(1*), Fitriya Andani(2), Yulistia Budianti Soemarie(3)

(1) Academy of Pharmacy Samarinda
(2) Academy of Pharmacy Samarinda
(3) Academy of Pharmacy Samarinda
(*) Corresponding Author

Abstract


Pain is a sensory and emotional feelings associated with tissue damage. Leaves kerehau recognized by people Dayak and Kutai as postpartum pain medication. Kerehau leaf has long been known by the public because many have efficacy in medicine. This research to determine the analgesic activity of ethanolic extract of leaves kerehau (Callicarpa longifolia Lamk.) on male white mice (Mus musculus). This is experimental research, randomized complete unidirectional pattern. The animals test were divided into 5 groups with each treatment of 5 mice. Group I (Na CMC 0.5% negative control), Group II (ibuprofen as a positive control), group III - V the ethanol extract of leaves kerehau dose of 150 mg , 300 mg and 600 mg/ Kg BW). Inductor pain acetic acid 0.5 % (ip). Observed number of writhing in mice for 1 hour and calculated percent analgesic . The results obtained in this study has efficacy as an analgesic with Strength of power dose I: 51.65 %, dose II: 65.40 %, and dose III: 75.98 %.

Keywords


analgetic, Callicarpa longifolia leaf, analgetic effect, asetic acid



References

Departemen Kesehatan RI. 1989. Materia Medika Indonesia Edisi IV. Jakarta: Departemen Kesehatan RI.

Fazriannur, 2015 Aktivitas Antioksidan Ekstrak Etanol Daun Kerehau( Callicarpa longifolia Lamk.) Dengan Metode Penangkal Radikal DPPH (2,2- Difenil 1-Pikrihidrazil). Karya Tulis Ilmiah. Samarinda : Akademi Farmasi

Gunawan, D. dan Mulyani,S. 2004. Ilmu Obat Alam (Farmakognosi). Jakarta : Penebar Swadaya.

Keth N.T., J. Gleye. Lavergne de Cervol, E. Stanisla, 1977, Flavonoides de Phyllanthus niruri L. P. urinaria L., P. orbiculatus LC. Rich, Tome XI, Plants Medicinales et Phytotherapie.

Lumbessy, M., Abidjulu, J., Paendong, J.E. 2013.Uji Total Flavonoid Pada Beberapa Tanaman Obat Tradisional Di Desa Kecamatan Mangoi Timur Kabupaten Kepulauan Sula Maluku Utara.JURNALI FMIPA UNSTRA.

Mohan, N., Gulecha, V.S., Aurangbadkar, V.M., Balaraman, R., Austin, A. & Thirugananasampathan, S. (2009). Analgesic And Anti-Inflammatory Activity of a Polyherbal Formulation (PHF-AROGH). Oriental Pharmacy and Experimental Medicine, 9 (3), 232-237.

Muhammad, N., Saeed, M. & Khan, H. (2012).Antypyretic,Analgesic And AntiInflammatory Activity of Viola betonicfolia Whole Plant. BMC

Semiawan, F., Ahmad, I., Masruhim, M. A. 2015.Aktifitas AntiInflamasi Ekstrak Etanol Daun Kerehau (Callicarpa longifolia Lamk) Jurnal Sains dan Kesehatan.(2015). Vol 1.No. 1. P-ISSN: 2303-0627, e-ISSN: 2407-608. Samarinda: Fakultas Farmasi Universitas Mulawarman.

Siregar, K., 1984. "Biostatistik Untuk Ilmu-Ilmu Kesehatan", FKM Universitas Indonesia, Jakarta.

Sudarsono, Pudjoarinto, A., Gunawan, D., Donatus, I.A., Drajad, M.,Wibowo, S.,dan Ngatidjan, 2006, Tumbuhan Obat I, Pusat Penelitian Obat Tradisional, Universitas Gadjah Mada, Yogyakarta.

Suryanto, E. 2013, Potensi Ekstrak Fenolik Buah Pisang Goroho (Musa Spp.) Terhadap Gula Darah Tikus Putih (Rattus norvegicus), Chem. Prog.,6 (1), 6-10

Tjay, T.H. dan Rahardja, K. 2007.Obat-obat penting.Edisi VI. Jakarta: PT. Elek Media Komputindo Kelompok Gramedia.



DOI: https://doi.org/10.22146/tradmedj.12824

Article Metrics

Abstract views : 5069 | views : 70330

Refbacks

  • There are currently no refbacks.


Bookmark and Share


Copyright (c) 2016 Majalah Obat Tradisional

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

©Majalah Obat Tradisional (Traditional Medicine Journal)
 ISSN 2406-9086
Faculty of Pharmacy
Universitas Gadjah Mada