Traditional medicine and its impact on patient outcomes in type 2 diabetes mellitus therapy
Keywords:
Compliance, Perception, Type 2 Diabetes Mellitus, Therapy Outcome
Abstract
The growing number of people with diabetes mellitus enhance the increasing number of antidiabetic medicine used and also the use of traditional medicine as a complementary medicine. The choice of treatment is depend on the patients’ perception and will have an effect on compliance and clinical outcome. This study aimed to determine the relationship between patients’ perception of consuming a combination of Traditional Medicine (TM) and Synthetic Medicine (SM) and their compliance with medication, as well as to examine its impact on the outcomes of type 2 DM treatment at three community health centers in Yogyakarta. This study is a cross-sectional study. Participants that met the inclusion criterias were 110 patients with type 2 diabetes mellitus who had been taking TM-SM combination at least one month at three community health centers in the City of Yogyakarta. The main outcome is the relationship between perception and compliance, as well as the outcome of therapy. Result showed that from 110 patients, only 40 (36.4%) had a good perception of the use of TM-SM combination, and 32 patients (29.1%) succeeded in adhering to the recommended administration of synthetic drugs. A total of 49 patients (44.5%) reported controlled blood sugar levels as the outcome of DM management. Patients' perception of drug combination was proven unrelated to patient compliance and treatment outcome (p> 0.05). For the conclusion, there is no relationship between patients’ perception of taking a combination medication with adherence and treatment outcomes.
Keywords: Compliance, Perception, Type 2 Diabetes Mellitus, Therapy Outcome
References
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Paramitha, M. D., & Rahamanisa, S. (2016). Ekstrak etanol herba sambiloto (Andrographis paniculata) sebagai antidiabetik terhadap mencit wistar terinduksi aloksan. Majority, 5(5), 75–79.
Rahmadani, M. A. (2018). Hubungan Kepatuhan Terapi Obat Terhadap Kualitas Hidup Pada Pasien Hipertensi Dengan Komplikasi Diabetes Melitus di Puskesmas Wilayah Kota Yogyakarta. Universitas Ahmad Dahlan.
Ranadheer Chowdary, P., Praveen, D., & Vijey Aanandhi, M. (2017). A prospective study on incidence of dyslipidemia in diabetes mellitus. Research Journal of Pharmacy and Technology. https://doi.org/10.5958/0974-360x.2017.00086.5
S.K, A., & Vijey Aanandhi, M. (2018). An improvement in patient compliance in diabetes mellitus. Research Journal of Pharmacy and Technology. https://doi.org/10.5958/0974-360X.2018.00108.7
Sabate, E. (2003). Adherence to Long-Term Therapies, Evidence for Action. Geneva: World Health Organization.
Schectman, J. M., Nadkarni, M. M., & Voss, J. D. (2002). The Association Between Diabetes Metabolic Control and Drug Adherence in an Indigent Population. Diabetes Care, 25(6), 1015–1021.
Sheikhrabori, A., Dehghan, M., Ghaedi, F., & Khademi, G. R. (2017). Complementary and Alternative Medicine Usage and Its Determinant Factors Among Diabetic Patients: An Iranian Case. Journal of Evidence-Based Complementary and Alternative Medicine, 22(3), 449–454. https://doi.org/10.1177/2156587216675079
Sugiyono. (2013). Metode Penelitian Administrasi. Bandung: Alfabeta.
Suswardany, D. L., Sibbritt, D. W., Supardi, S., Pardosi, J. F., Chang, S., & Adams, J. (2017). A cross-sectional analysis of traditional medicine use for malaria alongside free antimalarial drugs treatment amongst adults in high-risk malaria endemic provinces of Indonesia. 1–15.
Teo, T. Y., Yap, J., Shen, T., & Yeo, K. K. (2016). Complementary and alternative medicine use amongst patients with cardiovascular disease in Singapore. BMC Complementary and Alternative Medicine, 16(1), 1–7. https://doi.org/10.1186/s12906-016-1430-4
Torri, M. (2013). Knowledge and Risk Perceptions of Traditional Jamu Medicine among Urban Consumers. European Journal of Medicinal Plants, 3(1), 25–39. https://doi.org/10.9734/ejmp/2013/1813
Usman, Muh Amir, M., Erika, F., Nurdin, M., & Kuncoro, H. (2019). Antidiabetic activity of leaf extract from three types of mangrove originating from sambera coastal region Indonesia. Research Journal of Pharmacy and Technology. https://doi.org/10.5958/0974-360X.2019.00284.1
Wieland,L.Susan; Manheimer,E; Berman, B. (2011). Development and classification of an operational definition of complementary and alternative medicine for the Cochrane Collaboration. Altern Ther Health Med, 17(2), 50–59. https://doi.org/10.1038/jid.2014.371
World Health Organization. (2010). Traditional Medicine in Republic of Indonesia. 23–36. Retrieved from http://www.searo.who.int/entity/medicines/topics/traditional_medicines_in_republic_of_indonesia.pdf
World Health Organization. (2013). Adherence to Long-Term Therapies, Evidence for Action. In World Health Organization. https://doi.org/10.4028/www.scientific.net/AMM.321-324.1779
Arisman. (2010). Obesitas, diabetes mellitus & dislipidemia. Jakarta: Buku Kedokteran EGC.
Atinga, R. A., Yarney, L., & Gavu, N. M. (2018). Factors influencing long-term medication non-adherence among diabetes and hypertensive patients in Ghana: A qualitative investigation. PLoS ONE. https://doi.org/10.1371/journal.pone.0193995
Bahall, M., & Edwards, M. (2015). Perceptions of complementary and alternative medicine among cardiac patients in South Trinidad: A qualitative study. BMC Complementary and Alternative Medicine, 15(1), 1–10. https://doi.org/10.1186/s12906-015-0577-8
Departemen Kesehatan Republik Indonesia. (2007). KEBIJAKAN OBAT TRADISIONAL NASIONAL TAHUN 2007. Jakarta: Departemen Kesehatan Republik Indonesia.
Fadheel, Q. J. (2019). A comparative study of the effect of metformin and metformin plus garlic on blood glucose level in patients with type 2 diabetes mellitus in Iraq. Research Journal of Pharmacy and Technology. https://doi.org/10.5958/0974-360X.2019.00301.9
Falkenberg. (2015). Traditional and Complementary Medicine. In Procedia - Social and Behavioral Sciences (Vol. 170, pp. 262–271). https://doi.org/10.1016/j.sbspro.2015.01.036
Faridah, I. N., Putri, M. N. C., & Perwitasari, D. A. (2017). Validation of A New Questionnaire Assessing Knowledge and Perceptions about Combination between Herbal and Conventional Medicine ( Validasi Kuesioner Baru Menilai Pengetahuan dan Persepsi tentang Kombinasi antara Pengobatan Herbal dan Konvensional ). Jurnal Ilmu Kefarmasian Indonesia, 15(1), 109–113.
Farrukh, M. J., Makmor-Bakry, M., Hatah, E., & Tan, H. J. (2018). Use of complementary and alternative medicine and adherence to antiepileptic drug therapy among epilepsy patients: A systematic review. Patient Preference and Adherence, 12, 2111–2121. https://doi.org/10.2147/PPA.S179031
Gohar, F., Greenfield, S. M., Gareth Beevers, D., Lip, G. Y. H., & Jolly, K. (2008). Self-care and adherence to medication: A survey in the hypertension outpatient clinic. BMC Complementary and Alternative Medicine, 8(1), 1–9. https://doi.org/10.1186/1472-6882-8-4
International Diabetes Federation. (2017). Eight edition 2017. In IDF Diabetes Atlas, 8th edition. https://doi.org/http://dx.doi. org/10.1016/S0140-6736(16)31679-8.
Islahudin, F., & Hasan, S. Z. (2019). Medication adherence and satisfaction among patients in Malaysia. Research Journal of Pharmacy and Technology. https://doi.org/10.5958/0974-360X.2019.00173.2
Jafari, S., Sattari, R., & Ghavamzadeh, S. (2017). Evaluation the effect of 50 and 100 mg doses of Cuminum cyminum essential oil on glycemic indices, insulin resistance and serum inflammatory factors on patients with diabetes type II: A double-blind randomized placebo-controlled clinical trial. Journal of Traditional and Complementary Medicine, 7(3), 332–338. https://doi.org/10.1016/j.jtcme.2016.08.004
Jasamai, M., Islahudin, F., & Samsuddin, N. F. (2017). Attitudes towards complementary alternative medicine among Malaysian adults. Journal of Applied Pharmaceutical Science, 7(6), 190–193. https://doi.org/10.7324/JAPS.2017.70627
Joseph, Dhanish; George,Junia; Mathew, M. M. et al. (2019). A Compilation on Anti-Diabetic Profile of Cocos nucifera. Research J. Pharm. and Tech, 12(8), 3791–3796.
Kementerian Kesehatan Republik Indonesia. (2016). Peraturan Menteri Kesehatan Republik Indonesia Nomor 6 tahun 2016 tentang Formularium Obat Herbal Asli Indonesia. Jakarta: Kementerian Kesehatan Republik Indonesia.
Kementerian Kesehatan Republik Indonesia. (2018). Hasil Utama Riskesdas 2018. Jakarta: Kementerian Kesehatan Republik Indonesia.
Maheshwari, P., Pavithra, D., Neethu, T. T., Shanmugarajan, T. S., & Shanmugasundaram, P. (2017). Study on health outcomes in diabetic patients - association between diabetic foot ulcer and psychological distress. Research Journal of Pharmacy and Technology. https://doi.org/10.5958/0974-360X.2017.00011.7
Mathew,F;Varghese,Bimi;Joseph, D. et al. (2019). An Appraisal of Pharmacological actions of Morus indica: The Indian mulberry with a detailed investigation on its Anti-diabetic potential. Research J. Pharm. and Tech, 12(8), 3654–3658.
Mosihuzzaman, M., & Choudhary, M. I. (2008). Protocols on safety, efficacy, standardization, and documentation of herbal medicine (IUPAC technical report). Pure and Applied Chemistry, 80(10), 2195–2230. https://doi.org/10.1351/pac200880102195
Mounika, V., Sarumathy, S., Anisha Ebens, J., & Shanmugarajan, T. S. (2017). A prospective study on incidence of anaemia in type 2 diabetes mellitus patients. Research Journal of Pharmacy and Technology. https://doi.org/10.5958/0974-360X.2017.00003.8
Paramitha, M. D., & Rahamanisa, S. (2016). Ekstrak etanol herba sambiloto (Andrographis paniculata) sebagai antidiabetik terhadap mencit wistar terinduksi aloksan. Majority, 5(5), 75–79.
Rahmadani, M. A. (2018). Hubungan Kepatuhan Terapi Obat Terhadap Kualitas Hidup Pada Pasien Hipertensi Dengan Komplikasi Diabetes Melitus di Puskesmas Wilayah Kota Yogyakarta. Universitas Ahmad Dahlan.
Ranadheer Chowdary, P., Praveen, D., & Vijey Aanandhi, M. (2017). A prospective study on incidence of dyslipidemia in diabetes mellitus. Research Journal of Pharmacy and Technology. https://doi.org/10.5958/0974-360x.2017.00086.5
S.K, A., & Vijey Aanandhi, M. (2018). An improvement in patient compliance in diabetes mellitus. Research Journal of Pharmacy and Technology. https://doi.org/10.5958/0974-360X.2018.00108.7
Sabate, E. (2003). Adherence to Long-Term Therapies, Evidence for Action. Geneva: World Health Organization.
Schectman, J. M., Nadkarni, M. M., & Voss, J. D. (2002). The Association Between Diabetes Metabolic Control and Drug Adherence in an Indigent Population. Diabetes Care, 25(6), 1015–1021.
Sheikhrabori, A., Dehghan, M., Ghaedi, F., & Khademi, G. R. (2017). Complementary and Alternative Medicine Usage and Its Determinant Factors Among Diabetic Patients: An Iranian Case. Journal of Evidence-Based Complementary and Alternative Medicine, 22(3), 449–454. https://doi.org/10.1177/2156587216675079
Sugiyono. (2013). Metode Penelitian Administrasi. Bandung: Alfabeta.
Suswardany, D. L., Sibbritt, D. W., Supardi, S., Pardosi, J. F., Chang, S., & Adams, J. (2017). A cross-sectional analysis of traditional medicine use for malaria alongside free antimalarial drugs treatment amongst adults in high-risk malaria endemic provinces of Indonesia. 1–15.
Teo, T. Y., Yap, J., Shen, T., & Yeo, K. K. (2016). Complementary and alternative medicine use amongst patients with cardiovascular disease in Singapore. BMC Complementary and Alternative Medicine, 16(1), 1–7. https://doi.org/10.1186/s12906-016-1430-4
Torri, M. (2013). Knowledge and Risk Perceptions of Traditional Jamu Medicine among Urban Consumers. European Journal of Medicinal Plants, 3(1), 25–39. https://doi.org/10.9734/ejmp/2013/1813
Usman, Muh Amir, M., Erika, F., Nurdin, M., & Kuncoro, H. (2019). Antidiabetic activity of leaf extract from three types of mangrove originating from sambera coastal region Indonesia. Research Journal of Pharmacy and Technology. https://doi.org/10.5958/0974-360X.2019.00284.1
Wieland,L.Susan; Manheimer,E; Berman, B. (2011). Development and classification of an operational definition of complementary and alternative medicine for the Cochrane Collaboration. Altern Ther Health Med, 17(2), 50–59. https://doi.org/10.1038/jid.2014.371
World Health Organization. (2010). Traditional Medicine in Republic of Indonesia. 23–36. Retrieved from http://www.searo.who.int/entity/medicines/topics/traditional_medicines_in_republic_of_indonesia.pdf
World Health Organization. (2013). Adherence to Long-Term Therapies, Evidence for Action. In World Health Organization. https://doi.org/10.4028/www.scientific.net/AMM.321-324.1779
Published
2022-12-20
How to Cite
Faridah, I. N., Perwitasari, D. A., Maer, K., Octapermatasari, R., & Novitasari, L. (2022). Traditional medicine and its impact on patient outcomes in type 2 diabetes mellitus therapy. Indonesian Journal of Pharmacy, 33(4), 621-629. https://doi.org/10.22146/ijp.2541
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Research Article
