Potential of Macroalgae for Anti Alopecia: A Systematic Review
Keywords:
Macroalgae, Algae, Androgenetic alopecia, alopecia areata, mechanism of action
Abstract
Alopecia or baldness is a disease where the amount of hair that falls out is greater than the hair that grows. The most common alopecias are androgenetic alopecia (AGA) and alopecia areata (AA). Macroalgae contain secondary metabolites that have quite large ecological potential that can be utilized, namely red algae (Rhodophyta), green algae (Chlorophyta), and brown algae (Phaeophyta). Bioactive components one of the benefits of this macroalgae is as anti-alopecia. The purpose of this review article is to discuss a summary of the mechanisms of action of macroalgae with their active compounds for the treatment of alopecia by stimulating hair growth in hair follicles. This review uses the literature study method of several articles from the online databases PubMed, Sciencedirect, Google Scholar in the form of secondary data analysis with the keywords "algae for androgenetic alopecia and algae for alopecia". The results of this review presented 18 articles on different types of algae, which have the potential to become alternative anti- alopecia drugs with different mechanisms of action. From this review of macroalgae, it is hoped that it can be developed into an anti-alopecia herbal medicinal product.
References
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Danilenko, M., Ring, D., & Pierce, F. (1996). Growth factors and cytokines in insights from and the potentials. Molecular Medicine Today, 2(11), 460–467.
Festi, J. & A. L. (2022). Identifikasi jenis-jenis makroalga di perairan pantai sombano kabupaten wakatobi. Jurnal Penelitian Biologi Dan Kependidikan, 1(1), 11–24.
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6. https://doi.org/10.1186/1471-5945-13-15
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https://doi.org/10.1016/S0006-2952(02)00848-1
Huang. C-Yu, Huang. C-Yen, Yang. C, L. ., & Chang.J. (2022). Hair growth-promoting effects of Sargassum glaucescens oligosaccharides extracts. Journal of the Taiwan Institute of Chemical Engineers, 134, 104307. https://doi.org/10.1016/j.jtice.2022.104307
Huang, C. Y., Huang, C. Y., Yang, C. C., Lee, T. M., & Chang, J. S. (2022). Hair growth-promoting effects of Sargassum glaucescens oligosaccharides extracts. Journal of the Taiwan Institute of Chemical Engineers, 134, 104307. https://doi.org/10.1016/j.jtice.2022.104307
Jung-Il Kang, Jungeun Kim, Sang-Cheol Kim, Sang- Chul Han, Ji-Hyeok Lee, J. L., & Euijun Noh,
You-Jin Jeon, Eun-Sook Yoo, and H.-K. K.
(2020). The Effect of Glucopyranosyldiacylglycerol from padina.pdf. Kor. J. Pharmacogn., 51, 41–48.
Kang. Jung Il, Kim. Sang Cheol, K. M. K., & Boo. Hye Jin, Jeon. You Jin, Koh. Sang Young, Yoo. Eun Sook, Kang. Sung Myung, K. H. K. (2012). Effect of dieckol, a component of ecklonia cava, on the promotion of hair growth. International Journal of Molecular Sciences, 13(5), 6407–6423. https://doi.org/
10.3390/ijms13056407
Kang, J. Il, Kim, J., Kim, S. C., Han, S. C., Lee, J. H., Lee, J., Noh, E., Jeon, Y. J., Yoo, E. S., & Kang, H. K. (2020). The effect of Glucopyranosyldiacylglycerol from Padina arborescens on the prevention of hair-loss. Korean Journal of Pharmacognosy, 51(1), 41–48.
Kang, J. Il, Kim, M. K., Lee, J. H., Jeon, Y. J., Hwang, E. K., Koh, Y. S., Hyun, J. W., Kwon, S. Y., Yoo, E. S., & Kang, H. K. (2017). Undariopsis peterseniana promotes hair growth by the activation of Wnt/β-catenin and ERK pathways. Marine Drugs, 15(5). https://doi.org/10.3390/md15050130
Kang, J., Choi, Y. K., Han, S., Nam, H., Lee, G., Kang, J., Koh, Y. S., Hyun, J. W., Yoo, E., & Kang, H. (2022). 5-Bromo-3,4-dihydroxybenzaldehyde Promotes Hair Growth through Activation of Wnt/ -Catenin and Autophagy Pathways and Inhibition of TGF- Pathways in Dermal Papilla Cell.
Kang, J., Kim, E., Kim, M., Jeon, Y., & Kang, S. (2013). The Promoting Effect of Ishige sinicola on Hair
Growth. 1783–1799. https://doi.org/10.3390/md11061783
Kang, J., Kim, S. C., Han, S. C., Hong, H. J., Jeon, Y. J., Kim, B., Koh, Y. S., Yoo, E. S., & Kang, H. K. (2012). Hair-loss preventing effect of Grateloupia elliptica. Biomolecules and Therapeutics, 20(1), 118–120. https://doi.org/10.4062/biomolther.2012.2 0.1.118
Kang, J., Kim, S., Kim, M., Boo, H., & Jeon, Y. (2012). Effect of Dieckol , a Component of Ecklonia cava , on the Promotion of Hair Growth. 0067, 6407–6423. https://doi.org/10.3390/ijms13056407
Kang, J., Yoo, E., Hyun, J., Koh, Y., Lee, H., Ko, M., Ko, C., & Kang, H. (2016). Promotion Effect of Apo-
9 ′ -fucoxanthinone from Sargassum muticum on Hair Growth via the Activation of Wnt / β - Catenin and VEGF-R2. 39(8), 1273–1283.
Lachgar, S., Charveron, M., Gall, Y., & Bonafe, J. L. (1998). Minoxidil upregulates the expression of vascular endothelial growth factor in human hair dermal papilla cells. British Journal of Dermatology, 138(3), 407–411. https://doi.org/10.1046/j.1365-2133.1998.02115.x
Lee, S.W., Juhasz, M., Mobasher, P., Chloe Ekelem, C. and Mesinkovska, N. A. (2018). A Systematic Review of Topical Finasteride in the Treatment of Androgenetic Alopecia in Men and Women. J Drugs Dermatol, 17(1), 457–463.
Lee. Y.R, Bae. S, Kim. J.Y, Lee. J, Cho. D-Hyun, Kim. Hee-sik, An. In-sook, A. S. (2019). Monoterpenoid Loliolide Regulates Hair Follicle Inductivity of Human Dermal Papilla Cells by Activating the AKT/ β -Catenin Signaling Pathway. 29, 1830–1840.
Lestari, I. L., & Mita, S. R. (2013). Review: Potensi Alga Laut dan Kandungan Senyawa Biologisnya Sebagai Bahan Baku Kosmeseutikal. Farmaka, 14(1), 114–126.
Lolli, F., Pallotti, F., Rossi, A., Fortuna, M. C., Caro, G.,
Lenzi, A., Sansone, A., & Lombardo, F. (2017). Androgenetic alopecia: a review. Endocrine,
57(1), 9–17.https://doi.org/10.1007/s12020-017-1280- y
Mak, K. K. L., & Chan, S. Y. (2003). Epidermal growth factor as a biologic switch in hair growth
cycle. Journal of Biological Chemistry,278(28), 26120–26126. https://doi.org/
10.1074/jbc.M212082200
Meidan, V. M., & Touitou, E. (2001). Treatments for androgenetic alopecia and alopecia areata: Current options and future prospects. Drug 61(1), 53–69. https://doi.org/10.2165/00003495- 200161010-00006
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Published
2024-10-07
How to Cite
Ariani, L. W., Zulkarnain, A. K., Hertiani , T., & Nurrochmad, A. (2024). Potential of Macroalgae for Anti Alopecia: A Systematic Review. Indonesian Journal of Pharmacy. https://doi.org/10.22146/ijp.11860
Issue
Section
Review Article
