Studi Potensi Interaksi Obat pada Resep Polifarmasi di Dua Apotek Kota Bandung

https://doi.org/10.22146/jmpf.56931

Irianti Bahana Maulida Reyaan(1*), Cempaka Kuning(2), I Ketut Adnyana(3)

(1) Sekolah Farmasi, Institut Teknologi Bandung
(2) Sekolah Farmasi, Institut Teknologi Bandung
(3) Sekolah Farmasi, Institut Teknologi Bandung
(*) Corresponding Author

Abstract


Polypharmacy prescription very commonly occurs on patient’s prescription in every health facilities. Polypharmacy may increase the risk of Drug-drug Interactions (DDI’s) which mostly causes harm impact in the patient’s therapy. Drug interactions considered clinically significant if it increases the toxicity or decreases the effectiveness of therapy. The objective of this study was to analyze the potential drug interactions in polypharmacy prescriptions in two pharmacy at Bandung city in general, based on the severity, and mechanism. This study was a non-experimental study that was carried out retrospectively by taken prescription data that received by two Pharmacies in Bandung City for the period of October- December 2018. Samples were obtained by purposive sampling technique and were analyzed by using Stockley’s Drug Interaction 9th Edition and database such as micromedexsolutions.com to determine the potential for drug interactions based on its severity and mechanism of interactions. A total of 1218 prescriptions were analyzed,  of which 896 prescription  (73.56%) were included in the inclusion criteria, and 569 prescription (63.50%) had potential drug-drug interactions. Based on the severity, majority of drug-drug interaction is moderate (85.60%), followed by minor interactions (9.28%), and major interactions (5.12%). Based on the mechanism, majority of drug-drug interactions is pharmacodynamic interactions (90.34%), and followed by pharmacokinetic interactions (9.66%). Based on the many of potential drug interactions, polypharmacy prescribing should be avoided and management of potential DDI’s should be performed.


Keywords


Pharmacy; Drug-Drug Interactions (DDI); Polypharmacy

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References

  1. Baxter K. Stockley’s Drug Interaction, 9th edition, 2010. Pharmaceutical Press, London.
  2. Bushra R, Aslam N, Khan AY. Food-drug interactions. Oman Med J. 2011 Mar;26(2):77-83. doi: 10.5001/omj.2011.21.
  3. Siti Mariam, 2016. EVALUASI KEJADIAN INTERAKSI OBAT PADA PASIEN RAWAT INAP GERIATRI PENDERITA GAGAL JANTUNG. ath 1. https://doi.org/10.47219/ath.v1i1.42
  4. USA: Thomson Micromedex; 2010. Micromedex-Drug Reax System.
  5. Patel VK, Acharya LD, Rajakannan T, Surulivelrajan M, Guddattu V, Padmakumar R. Potential drug interactions in patients admitted to cardiology wards of a south Indian teaching hospital. Australas Med J. 2011;4(1):9-14. doi:10.4066/AMJ.2011.450
  6. Palleria C, Di Paolo A, Giofrè C, Caglioti C, Leuzzi G, Siniscalchi A, De Sarro G, Gallelli L. Pharmacokinetic drug-drug interaction and their implication in clinical management. J Res Med Sci. 2013 Jul;18(7):601-10
  7. Hermann M, Carstens N, Kvinge L, Fjell A, Wennersberg M, Folleso K, Skaug K, Seiger A, Cronfalk BS, Bostrom AM. Polypharmacy and Potential Drug–Drug Interactions in Home-Dwelling Older People – A Cross-Sectional Study. J Multidiscip Healthc. 2021;14:589-597 https://doi.org/10.2147/JMDH.S297423
  8. Herdaningsih S, Muhtadi A, Lestari K, Annisa N. Potensi Interaksi Obat-Obat pada Resep Polifarmasi : Studi Retrospektif pada Salah satu Apotek di Kota Bandung. Indones J Clin Pharm. 2016;5(4) : 288-292.
  9. Sjahadat GA, Mutmainah S. Analisis Interaksi Obat Pasien Rawat Inap Anak di Rumah Sakit di Palu Indones J Clin Pharm. 2013; 2(4): 153-158.
  10. Kulkarni V, Bora SS, Sirisha S, Saji M, Sundaran S. A study on drug-drug interactions through prescription analysis in a South Indian teaching hospital. Ther Adv Drug Saf. 2013 Aug;4(4):141-6. doi: 10.1177/2042098613490009
  11. Risna Agustina, Nurul Annisa, Wisnu Cahyo Prabowo, 2015. Potensi Interaksi Obat Resep Pasien Hipertensi di Salah Satu Rumah Sakit Pemerintah di Kota Samarinda. J. Sains. Kes. 1. https://doi.org/10.25026/jsk.v1i4.41
  12. Monégat, M., 2014. Polypharmacy: definitions, measurement and stakes involved. Review of the literature and measurement tests 8.
  13. Dasopang, E., Urip Harahap, Dharma Lindarto. Polifarmasi dan Interaksi Obat Pasien Usia Lanjut Rawat Jalan dengan Penyakit Metabolik, Indones J Clin Pharm. 2015; 4(4): 235-241.
  14. Sari A, Wahyono D, Raharjo B. Identifikasi potensi interaksi obat pada pasien rawat inap penyakit dalam di RSUP Prof. dr. Margono Soekarjo Purwokerto dengan metode observasional retrospektif periode November 2009 – Januari 2010, Pharmaciana, 2012;2(2): 195–203.
  15. Nursanti, Fitri. Potensi Interaksi Obat Pada Resep Pasien Pediatri Studi Retrospektif di 3 Apotek Kota Surakarta Periode Juli - Desember 2014. Skripsi thesis, Universitas Muhammadiyah Surakarta. 2016
  16. BNF, British National Formulary, ed 76, 2016. BMJ Publishing Group, London, 1332.
  17. Rama M, Viswanathan G, Acharya LD, Attur RP, Reddy PN, Raghavan SV. Assessment of Drug-Drug Interactions among Renal Failure Patients of Nephrology Ward in a South Indian Tertiary Care Hospital. Indian J Pharm Sci. 2012;74(1):63-68. doi:10.4103/0250-474X.102545
  18. Pasangka IT, Tjitrosantoso H, Lolo WA. Identifikasi Potensi Interaksi Obat pada Pasien Gagal Ginjal Rawat Inap di RSUP Prof. Dr. D. Kandou Manado.Pharmacon. 2012; 6(4) : 119-129.
  19. Palanisamy S, Arul Kumaran KS, Rajasekaran A. A Study on Assessment, Monitoring, Documentation, and Reporting of Adverse Drug Reactions at a Multy-Speciality Tertiary CareTeaching Hospital in South India. Int J Pharm Tech Res. 2009;4:1519-1522.
  20. Ansari J. Drug interaction and pharmacist. J Young Pharm. 2010;2(3):326-331. doi:10.4103/0975-1483.66807



DOI: https://doi.org/10.22146/jmpf.56931

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