* Corresponding Author
FAKTOR RISIKO KEJADIAN DRUG RELATED PROBLEMS PADA PASIEN PENYAKIT KRONIS RAWAT JALAN DI POLIKLINIK PENYAKIT DALAM
https://doi.org/10.22146/jmpf.260 Yovita Dwi Arini(1*), Fita Rahmawati(2), Tri Murti Andayani(3)
(1)
(2)
(3)
(*) Corresponding Author
Abstract
Peranan farmasi klinik antara lain mengidentifikasi, mencegah, dan mengatasi Drug Related Problems (DRPs). Penelitian - penelitian sebelumnya menunjukkan faktor risiko terjadinya DRPs antara lain: usia, jenis kelamin, polifarmasi, jumlah obat yang diterima, diagnosa serta penyakit penyerta. Prevalensi penyakit dalam menurut Riskesdas pada tahun 2013 cenderung mengalami peningkatan. Oleh karena itu perlu adanya penelitian yang bertujuan untuk mengkaji hubungan faktor risiko terhadap kejadian DRPs pada pasien penyakit dalam. Penyakit kronis yang diteliti adalah diabetes melitus, hipertensi, hipertiroid, hipotiroid, sirosis hepatik dan PPOK.
Penelitian ini merupakan penelitian case control dengan pengambilan data menggunakan metode purposive sampling. Data diambil dari resep rawat jalan poliklinik penyakit dalam pada bulan Mei 2015. Analisis data dilakukan dengan statistik deskriptif untuk menunjukkan kejadian DRPs. Untuk melihat hubungan faktor risiko dengan DRPs digunakan Metode Chi square dengan tingkat kepercayaan 95%. Untuk mengetahui hubungan antar faktor-faktor risiko dianalisis dengan metode regresi linear logistik berpasangan (multivariat).
Hasil peneltian menunjukkan sebanyak 185 kejadian DRPs pasien rawat jalan dengan penyakit kronis Jenis kejadian DRP berturut- turut dari yang paling banyak adalah indikasi tanpa terapi 46 kejadian (24,73%), dosis obat berlebih 41 kejadian (22,04%), ROTD 41 kejadian (22,04%), obat tidak efektif 38 kejadian (20,43%), terapi tanpa indikasi 11 kejadian (5,92%) dan dosis obat kurang sebanyak 9 kejadian (4,48%). Usia lanjut, multiple comorbid, dan polifarmasi, berpengaruh terhadap kejadian DRPs (p < 0,05).
Kata kunci: faktor risiko, DRPs, peresepan rawat jalan, penyakit kronis
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Allemann, S.S., van Mil, J.W.F., Botermann, L., Berger, K., Griese, N., dan Hersberger, K.E., 2014. Pharmaceutical Care: the PCNE definition 2013. International Journal of Clinical Pharmacy, 36: 544–555.
ASH, A.H.C., 2015. 'American Diabetes Association 2015 Summary PDF.pdf', http://www.ndei.org.URL:http://www.ndei.org/uploadedFiles/Common/NDEI/Treatment_Guidelines/ADA%202015%20Summary%20PDF.pdf (diakses tanggal 17/3/2016).
Basheti, I.A., Qunaibi, E.A., Bulatova, N.R., Samara, S., dan AbuRuz, S., 2013. Treatment related problems for outpatients with chronic diseases in Jordan: the value of home medication reviews. International Journal of Clinical Pharmacy, 35: 92–100.
Blix, H.S., Viktil, K.K., Reikvam, S., Moger, T.A., Hjemaas, B.J., Pretsch, P., dkk., 2004. The majority of hospitalised patients have drug-related problems: results from a prospective study in general hospitals. European Journal of Clinical Pharmacology, 60: 651–658.
Bruix, J. dan Sherman, M., 2005. AASLD (American Association for the Study of Liver Diseases) PRACTICE GUIDELINE-Management of Hepatocellular Carcinoma. Hepatology, .
Camargo, A.L., Cardoso Ferreira, M.B., dan Heineck, I., 2006. Adverse drug reactions: a cohort study in internal medicine units at a university hospital. European Journal of Clinical Pharmacology, 62: 143–149.
Chobanian, A.V., 2004. JNC-7-Full Text.pdf.
Cipolle, R.J., Strand, L.M., dan Morley, P.C., 2004. Pharmaceutical Care Practice : The Clinician’s Guide, 2nd ed. McGraw-Hill Companies.
DiPiro, J.T., Talbert, R., Yee, G., Wells, B., dan Posey, L. (Editor), 2014. Pharmacotherapy: A Pathophysiologic Approach, 9th ed. ed. McGraw-Hill Medical, New York.
Gandhi, T.K., Weingart, S.N., Borus, J., Seger, A.C., Peterson, J., Burdick, E., dkk., 2003. Adverse Drug Events in Ambulatory Care. New England Journal of Medicine, 348: 1556–1564.
Huang, T., Ren, J., Huang, J., dan Li, D., 2013. Association of homocysteine with type 2 diabetes: a meta-analysis implementing Mendelian randomization approach. BMC genomics, 14: 1.
Huri, H.Z. dan Wee, H.F., 2013. Drug Related Problems in type 2 diabetes patient with hypertension: a cross-sectional study. OPlosOne, , BMC Endocrine Disorder 13: 1–12.
InaSH, P.D.H.I., 2014. Konsensus Penatalaksanaan Hipertensi 2014. Perhimpunan Dokter Hipertensi Indonesia, Jakarta.
Khanna, D., Fitzgerald, J.D., Khanna, P.P., Bae, S., Singh, M.K., Neogi, T., dkk., 2012. 2012 American College of Rheumatology guidelines for management of gout. Part 1: Systematic nonpharmacologic and pharmacologic therapeutic approaches to hyperuricemia. Arthritis Care & Research, 64: 1431–1446.
Kemenkes RI, 2013. 'Riset Kesehatan Dasar', , RISKESDAS 2013. Badan Penelitian dan Pengembangan Kesehatan Kementrian Kesehatan RI, Jakarta.
Lexicom, 2015. Drug Information Handbook - A Clinically Relevant Resource Fo All Healthcare Professionals, 24th ed. Wolters Kluwer, USA.
Lopez-Sendon, J., McMurray, J., Dargie, H., Lechat, P., Swedberg, K., Tamargo, J., dkk., 2004. ECS guide - Beta Blocker in Cardiovascular Diabetes.pdf. Elsevier, , European Heart Journal 25: 1341–1362.
Limpawattana, P., 2013. Potentially inappropriate prescribing of Thai older adults in an internal medicine outpatient clinic of a tertiary care hospital. African Journal of Pharmacy and Pharmacology, 7: 2417–2422.
Martí-Carvajal, A.J., Solà, I., dan Lathyris, D., 2015. Homocysteine-lowering interventions for preventing cardiovascular events, dalam: The Cochrane Collaboration (Editor), Cochrane Database of Systematic Reviews. John Wiley & Sons, Ltd, Chichester, UK.
Mulder, W.M.C., Meinardi, M., dan Boxtel, C. van, 2004. Outpatient clinic for drug related problems. International Journal of Risk and Safety in Medicine, 16: 171–176.
Nicolas, A., Eickhoff, C., Griese, N., dan Schulz, M., 2013. Drug-related problems in prescribed medicines in Germany at the time of dispensing. International Journal of Clinical Pharmacy, 35: 476–482.
Nurcahya, B.M., 2015. 'Identifikasi dan Analisis Faktor Risiko Kejadian DRPs pada Pasien Rawat Jalan dengan Penyakit Kronis di RS Yogyakarta', , Thesis, . Universitas Gadjah Mada, Yogyakarta.
PERKENI, P.E.I., 2012. Konsensus Pengelolaan Dislipidemia di Indonesia 2012. PERKENI, Jakarta.
Rosendorff, C., Lackland, D.T., Aronow, W.S., Black, H.R., Blumenthal, R.S., Lemos, J.A. de, dkk., 2015. Treatment of Hypertension in Patients With Coronary Artery Disease. American Heart Association, Inc., the American College of Cardiology Foundation, and American Society of Hypertension, Inc, 1–37.
Redmon, B., Caccamo, D., Flavin, P., Michels, R., O’Connor, P., Roberts, J., dkk., 2014. Diagnosis and management of type 2 diabetes mellitus in adults. Institute for Clinical Systems Improvement. Updated July, .
Reiner, Z., Catapano, A.L., De Backer, G., Graham, I., Taskinen, M.-R., Wiklund, O., dkk., 2011. ESC/EAS Guidelines for the management of dyslipidaemias: The Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS). European Heart Journal, 32: 1769–1818.
Sudchada, P., Saokaew, S., Sridetch, S., Incampa, S., Jaiyen, S., dan Khaithong, W., 2012. Effect of folic acid supplementation on plasma total homocysteine levels and glycemic control in patients with type 2 diabetes: A systematic review and meta-analysis. Diabetes Research and Clinical Practice, 98: 151–158.
Soendergaard, B., Kirkeby, B., Dinsen, C., Herborg, H., Kjellberg, J., dan Staehr, P., 2006. Drug-related problems in general practice: results from a development project in Denmark. Pharmacy World & Science, 28: 61–64.
Towheed, T., Maxwell, L., Anastassiades, T.P., Shea, B., Houpt, J., Welch, V., dkk., 2005. Glucosamine therapy for treating osteoarthritis, dalam: The Cochrane Collaboration (Editor), Cochrane Database of Systematic Reviews. John Wiley & Sons, Ltd, Chichester, UK.
WHO, 2016. 'WHO | Women’s health', WHO. URL:http://www.who.int/mediacentre/factsheets/fs334/en/ (diakses tanggal 22/3/2016) DOI: https://doi.org/10.22146/jmpf.260
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