Level kadmium darah dan fungsi ginjal ditinjau dari kadar ureum dan kreatinin pekerja las bengkel knalpot di Purbalingga

Septiono Bangun Sugiharto; Suwarso Suwarso; Widharto Prawirohardjono

doi:10.22146/bkm.7326

Level kadmium darah dan fungsi ginjal ditinjau dari kadar ureum dan kreatinin pekerja las bengkel knalpot di Purbalingga

https://doi.org/10.22146/bkm.7326

Septiono Bangun Sugiharto^(1*), Suwarso Suwarso⁽²⁾, Widharto Prawirohardjono⁽³⁾

(1) Departemen Perilaku Kesehatan, Lingkungan, dan Kedokteran Sosial, Fakultas Kedokteran, Universitas Gadjah Mada
(2) Departemen Patologi Klinik, Fakultas Kedokteran, Universitas Gadjah Mada
(3) Departemen Farmakologi dan Farmakoterapi, Fakultas Kedokteran, Universitas Gadjah Mada
(*) Corresponding Author

Abstract

Level of cadmium and kidney function reviewed from ureum rate and kreatinin of exhaust welding workers

Purpose

This research aimed to analyze the correlation between levels of cadmium level in blood and decreasing kidney function reviewed from ureum and creatinine levels in exhaust welders in Purbalingga Lor.

Method

This research used a cross-sectional design. Samples were counted by using random sampling formula and there were 36 respondents chosen. 32 respondents participated in this research.

Results

There was no correlation between the outside variables (age, smoking habit, self higienity, working period, the number of working hours per week, use of the mask) and the independent variable (levels of cadmium). There was no correlation between independent variable (levels of cadmium) and dependent variables (levels of ureum and creatinine) on exhaust welders in Purbalingga Lor.

Conclusion

This study contributes to the knowledge that levels of cadmium in the blood have no correlation on the levels of ureum and creatinine in kidneys of exhaust welding workers. This study recommends to develop research on other types of heavy metals that may potentially interfere with the health of welding workers.

Keywords

levels of cadmium; ureum; creatinine; exhaust welding worker

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References

Luckett BG, Su LJ, Rood JC, Fontham ET. Cadmium exposure and pancreatic cancer in south Louisiana. Journal of environmental and public health. 2012;2012.
Idham, Muhamad. Studi tentang Hubungan Pemaparan Fume Cadmium dan Penggunaan Alat Pelindung Diri dengan Kadar Cadmium dalam Darah Pekerja di Bagian Pengelasan PT. YIMM Tahun 2004. Tesis. Program Studi Magister Keselamatan dan Kesehatan Kerja, Fakultas Kesehatan Masyarakat, Universitas Indonesia, Jakarta. 2004.
Aminian O, Eftekhari S, Mazaheri M, Sharifian SA, Sadeghniiat-Haghighi K. Urinary [Beta] 2 Microglobulin in Workers Exposed to Arc Welding Fumes. Acta Medica Iranica. 2011 Nov 1;49(11):748.
Kile ML, Fang S, Baccarelli AA, Tarantini L, Cavallari J, Christiani DC. A panel study of occupational exposure to fine particulate matter and changes in DNA methylation over a single workday and years worked in boilermaker welders. Environmental Health. 2013 Dec;12(1):47.
Rumahlatu D. Biomonitoring: Sebagai Alat Asesmen Kualitas Perairan Akibat Logam Berat Kadmium pada Invertebrata Perairan. SAINSTIS. 2012 Apr 23.
Bernard A. Cadmium & its adverse effects on human health. Indian Journal of Medical Research. 2008 Oct 1;128(4):557.
Johri N, Jacquillet G, Unwin R. Heavy metal poisoning: the effects of cadmium on the kidney. Biometals. 2010 Oct 1;23(5):783-92.
Sudoyo AW, Bambang S, Idrus A, Marcellus SK, Siti S. Buku Ajar Ilmu Penyakit Dalam. Jilid II Edisi V. Penerbit: Interna Publishing, Jakarta. 2009.
Liu Jie, Robert A, Goyer, Michael P, Waalkes. Toxic Effects of Metals. Casarett and Doull’s Toxicology The Basic Science of Poisons. Seventh Edition. By The McGraw-Hill Companies, Inc. 2008.
Olsson M, Bensryd I, Lundh T, Ottosson H, Skerfving S, Oskarsson A. Cadmium in blood and urine--impact of sex, age, dietary intake, iron status, and former smoking--association of renal effects. Environmental health perspectives. 2002 Dec;110(12):1185.
Ghazali AR, Razak A, Ezzazulianie N, Othman MS, Othman H, Ishak I, Lubis SH, Mohammad N, Abd Hamid Z, Harun Z, Kamarulzaman F. Study of heavy metal levels among farmers of Muda Agricultural Development Authority, Malaysia. Journal of environmental and public health. 2012;2012.
Hambach R. D Lison, PC D’Haese, J Weyler, E De Graef, A De Schryver, LV Lamberts, M Van Sprundel. Co-exsposure to leads increases the renal response to low levels of cadmium in metallurgy workers. Toxicology Letters 222 (2013) 233-238.
Mulder TP, Peters WH. Variability of glutathione S-transferase α in human liver and plasma. Clinical chemistry. 1999 Mar 1;45(3):355-9.
Yang H, Shu Y. Cadmium transporters in the kidney and cadmium-induced nephrotoxicity. International journal of molecular sciences. 2015 Jan 9;16(1):1484-94.
Bernhoft Robin A. Cadmium Toxicity and Treatment. Review Article. Hindawi Publishing Corporation. The Scientific World Journal. 2013.
Deviandhoko D, Wahyuningsih NE, Nurjazuli N. Faktor-Faktor Yang Berhubungan Dengan Gangguan Fungsi Paru Pada Pekerja Pengelasan di Kota Pontianak. Jurnal Kesehatan Lingkungan Indonesia. 2013 May 30;11(2):123-9.
El Safty A, Helal S, Maksoud NA, Samir A. Occupational Health Hazards among Double Sided Printed Circuit Board Manufacturers. British Journal of Applied Science & Technology. 2014 Apr 11;4(11):1634.