CEA and Cyfra 21-1 linked to serial miRNA expressions of advanced-stage non-small cell lung cancer in Indonesia

https://doi.org/10.19106/JMedSci005504202303

Arif Riswahyudi Hanafi(1*), Achmad Mulawarman Jayusman(2), Priscillia Imelda(3), Serafim Alfasunu(4), Ahmad Hamim Sadewa(5), Dibyo Pramono(6), Didik Setyo Heriyanto(7), Sofia Mubarika Haryana(8), Siti Boedina Kresno(9)

(1) Department of Pulmonology, Dharmais Cancer Hospital, Jakarta
(2) Department of Pulmonology, Dharmais Cancer Hospital, Jakarta
(3) Lung Cancer Research Team, Department of Pulmonology, Dharmais Cancer Hospital, Jakarta
(4) Department of Pulmonology, Dharmais Cancer Hospital, Jakarta
(5) Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta
(6) Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta
(7) Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta
(8) Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta
(9) Department of Clinical Pathology, Dharmais Cancer Hospital, Jakarta
(*) Corresponding Author

Abstract


Globally, lung cancer is one of the cancers leading to dead, dominated by non-small cell lung cancer (NSCLC). In a previous study has shown those serial miRNA expressions (miR-148, miR-34, miR-222, and miR-155) had prognostic value in advanced-stage NSCLC patients. Meanwhile, CEA and Cyfra 21-1, pulmonary tumor markers, are sometimes considered in the Department of Pulmonology, Dharmais Cancer Hospital, Jakarta, although they are not used in routine clinics for prognostication. Both miRNA and CEA-Cyfra 21-1 are valuable biomarkers in NSCLC. This study aimed to evaluate their correlation between CEA and/or Cyfra 21-1 with miRNA expressions in NSCLC patients. It was a cohort retrospective study using data from the previous study. The correlation between variables was analyzed by Spearman-rho. A positive correlation was observed between CEA and Cyfra 21-1 with miR-148, miR-222, and miR-155 [(CEA: p=0.00369, r=0.522; p=0.00242, r=0.542; p 0.00106, r=0.576) (Cyfra: 21-1= p 0.01252, r=0.378; p=0.00035, r=0.519; p=0.01532, r=0.368)]. In conclusion, CEA and Cyfra 21-1 correlate with miR-148, miR-222, and miR-155 expressions in advanced-stage NSCLC.


Keywords


Advanced stage NSCLC, CEA, Cyfra-21-1, miRNA

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References


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DOI: https://doi.org/10.19106/JMedSci005504202303

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