Pro-inflammatory cytokine (IL-6) and total count lymphocyte profiles in COVID-19 patients with different severity levels
Shinta Dewi Permata Sari(1*), Wening Tri Mawanti(2), Dewi Martalena(3), Erlin Listiyaningsih(4), Rizkyana Avissa(5), Rini Latifah(6), Wawang S Sukarya(7)
(1) Faculty of Medicine, Universitas Muhammadiyah Prof. DR. HAMKA, Jakarta
(2) Faculty of Medicine, Universitas Muhammadiyah Prof. DR. HAMKA/Jakarta Islamic Hospital, Pondok Kopi, Jakarta
(3) Faculty of Medicine, Universitas Muhammadiyah Prof. DR. HAMKA/Jakarta Islamic Hospital, Pondok Kopi, Jakarta
(4) Faculty of Medicine, Universitas Muhammadiyah Prof. DR. HAMKA, Jakarta
(5) Faculty of Medicine, Universitas Muhammadiyah Prof. DR. HAMKA, Jakarta
(6) Faculty of Medicine, Universitas Muhammadiyah Prof. DR. HAMKA, Jakarta/Dr. M Goenawan Partowidigdo Pulmonary Hospital, Bogor, Indonesia
(7) Faculty of Medicine, Universitas Muhammadiyah Prof. DR. HAMKA, Jakarta
(*) Corresponding Author
Abstract
Keywords
Full Text:
PDFReferences
Li Q, Guan X, Wu P, Wang X, Zhou L, Tong Y, et al. Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia. N Engl J Med 2020; 382(13):1199-207.
https://doi.org/10.1056/NEJMoa2001316
2.https://covid19.go.id/peta-sebaran. Peta Sebaran.
3.Aziza L, Aqmarina A, Ihsan M. Pedoman pencegahan dan pengendalian Corona virus disease (COVID-19). Kementrian Kesehatan, RI; 2020.
4.Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 2020; 395(10223): 497-506.
https://doi.org/10.1016/S0140-6736(20)30183-5
5.Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel Coronavirus-infected pneumonia in Wuhan, China. JAMA 2020; 323(11):1061-9.
https://doi.org/10.1001/jama.2020.1585
6.Duan G. Intuition on virology, epidemiology, pathogenesis, and control of COVID-19. Nov Res Microbiol J 2020; 4(5):955-67.
https://doi.org/10.21608/nrmj.2020.118446
7.Woo YL, Kamarulzaman A, Augustin Y, Staines H, Altice F, Krishna S. A genetic predisposition for cytokine storm in life threatening COVID-19 infection. J Petrol 2013; 369(1):1689-99.
8.Cárdenas DM, Sánchez AC, Rosas DA, Rivero E, Paparoni MD, Cruz MA, et al. Preliminary analysis of single-nucleotide polymorphisms in IL-10, IL-4, and IL-4Rα genes and profile of circulating cytokines in patients with gastric cancer. BMC Gastroenterol 2018; 18(1):1-13.
https://doi.org/10.1186/s12876-018-0913-9
9.Nielsen HG, Øktedalen O, Opstad P-K, Lyberg T. Plasma cytokine profiles in long-term strenuous exercise. J Sports Med 2016; 2016:1-7.
https://doi.org/10.1155/2016/7186137
10.Polz-Dacewicz M, Strycharz-Dudziak M, Dworzański J, Stec A, Kocot J. Salivary and serum IL-10, TNF-α, TGF-β, VEGF levels in oropharyngeal squamous cell carcinoma and correlation with HPV and EBV infections. Infect Agent Cancer 2016; 11(1):1-8.
https://doi.org/10.1186/s13027-016-0093-6
11.de Brito R de CCM, Lucena-Silva N, Torres LC, Luna CF, Correia J de B, da Silva GAP. The balance between the serum levels of IL-6 and IL-10 cytokines discriminates mild and severe acute pneumonia. BMC Pulm Med 2016; 16(1):19-21.
https://doi.org/10.1186/s12890-016-0324-z
12.Marin BG, Aghagoli G, Lavine K, Yang L, Siff EJ, Chiang SS, et al. Predictors of COVID-19 severity: a literature review. Rev Med Virol 2021; 31(1):1-10.
https://doi.org/10.1002/rmv.2146
13.Zhang J, Hao Y, Ou W, Ming F, Liang G, Qian Y, et al. Serum interleukin-6 is an indicator for severity in 901 patients with SARS-CoV-2 infection: a cohort study. J Transl Med 2020; 18(1):1-8.
https://doi.org/10.1186/s12967-020-02571-x
14.Kumar S, Kumari N, Mittal RD, Mohindra S, Ghoshal UC. Association between pro-(IL-8) and anti-inflammatory (IL-10) cytokine variants and their serum levels and H. pylori-related gastric carcinogenesis in northern India. Meta Gene 2015; 6:9-16.
https://doi.org/10.1016/j.mgene.2015.07.008
15.Mehta P, McAuley D, Brown M, Sanchez E, Tattersall R, Manson J. COVID-19: consider cytokine storm syndromes and immunosuppression. Lancet 2020; 395(10229):1033-4.
https://doi.org/10.1016/S0140-6736(20)30628-0
16.Jafarzadeh A, Jafarzadeh S, Nozari P, Mokhtari P, Nemati M. Lymphopenia an important immunological abnormality in patients with COVID-19: possible mechanisms. Scand J Immunol 2021; 93(2):1-16.
https://doi.org/10.1111/sji.12967
17.Chen G, Wu D, Guo W, Cao Y, Huang D, Wang H, et al. Clinical and immunological features of severe and moderate coronavirus disease 2019. J Clin Invest. 2020; 130(5):2620-9.
https://doi.org/10.1172/JCI137244
DOI: https://doi.org/10.19106/JMedSci005303202101
Article Metrics
Abstract views : 2682 | views : 2453Copyright (c) 2021 Shinta Dewi Permata Sari, Wening Tri Mawanti, Dewi Martalena, Erlin Listiyaningsih, Rizkyana Avissa, Rini Latifah, Wawang S Sukarya
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
-