The rotavirus causing acute gastroenteritis in children of under 5-year of age in Indonesia 1972-2018: a review

https://doi.org/10.19106/JMedSci005301202105

Abu Tholib Aman(1*)

(1) Department of Microbiology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta
(*) Corresponding Author

Abstract


The reason of this review is the absence of thorough information of rotavirus
infection that had been the major cause of severe diarrhea in children of under
5-years of age in Indonesia, despite numerous publications elaborating rotavirus
infection in some geographic areas of Indonesia. A review was conducted
towards 52 published articles covering rotavirus research in Indonesia during
period of 1972-2018.A thirty three selected articles were match with review
criteria which comprises rotavirus positive rate, clinical features, and severity
of rotavirus infection, as well as genotypes of the rotavirus. Rotavirus has been
known as the major cause of severe diarrhea among children under 5 years of
age world wide including in Indonesia. The rotavirus positive rates were range
from 31.1 to 90.9%, which variably to different subject’s population, study
criteria and methods, and time. Rotavirus can cause severe diarrhea with
majority of infected children suffered from dehydration, vomiting, and fever.
The first genotyping conducted in Indonesia in the early 1980s revealed the
predominant genotypes were G3 and G4, followed by G2, and small proportion
of G1 and mixed genotypes. However the following decades G1 and G2 were on
the raise with G3 predominantly re-appeared on 2015. G9 was first identified in
2004, and occasionally detected until 2015. The P genotyping revealed P[4], P[6],
and P[8] were the common genotypes detected. Mixed and untyped genotypes
were also detected in various proportion. Rotavirus diarrhea is a vaccination
preventable disease, after natural infection, the immune system will produce
protective antibodies that will protect from infection of both homotypic and
heterotypic, however homotypic infection will protect stronger. Therefore this
review recommends continuous rotavirus genotypes surveillance in Indonesia.

Keywords


otavirus;children of under 5-years of age; Indonesia

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DOI: https://doi.org/10.19106/JMedSci005301202105

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Journal of the Medical Sciences (Berkala Ilmu Kedokteran) by  Universitas Gadjah Mada is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
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