THE INFLUENCE OF LATIHAN PASRAH DIRI ON INSULIN RESISTENCE IN INDIVIDUALS WITH DIABETES MELLITUS TYPE 2 WITHOUT DEPRESSION



Agus Siswanto(1*), Muhammad Juffrie(2), Bambang Udji Djoko Rianto(3), H.A.H Asdie(4)

(1) Doctoral Programme of Medical Science Faculty of Medicine, Universitas Gajah Mada
(2) Doctoral Programme of Medical Science Faculty of Medicine, Universitas Gajah Mada
(3) Doctoral Programme of Medical Science Faculty of Medicine, Universitas Gajah Mada
(4) Doctoral Programme of Medical Science Faculty of Medicine, Universitas Gajah Mada
(*) Corresponding Author

Abstract


Abstract

Background. Latihan Pasrah Diri (LPD) is a relatively new form of relaxation therapy that has been increasingly used, not only in the treatment of psychosomatic diseases, but also of other non-psychosomatic diseases. This is supported by so many researches addressing LPD that showed modest improvement on clinical parameters of patients with chronic diseases and infections, one of which is diabetes. Therapy with LPD not only improves symptoms of depression, but also glycemic control. However, it is still not known whether LPD also affects insulin resistance.

Method. This research is a prospective, single-blinded, randomized, controlled trial conducted in outpatient unit of Internal Medicine Department in RSUP dr. Soeradji Tirtonegoro Klaten for 8 weeks. The subjects of the study were patients aged over 30 years diagnosed with diabetes mellitus and having no depression (evidenced by Beck Depression Inventory value <17). The data collected were insulin resistance, as measured by HOMA-IR, Perceived Stress Scale (PSS), fasting blood sugar (GDP), HbA1c, and 2 hour post prandial blood sugar (GD2JPP). Statistical analysis was performed by conducting the test of mean difference between control group and treatment group.

Result. The subjects consisted of 44 people, randomized into 2 groups, the control group and the treatment group (LPD group). There was no significant difference in the baseline characteristics of the two groups. At the end of the research period, the LPD group showed insignificant decrease of HOMA-IR and HbA1c, (ΔHOMA-IR = -0.54 ± 3.27; p = 0.425; ΔHbA1c = -0.39% ± 0.88% ; p = 0.45). Meanwhile, the GDP and GD2JPP was increased insignificantly in the LPD group compared to control (ΔGDP = 20.18 ± 65.34; p = 0.296; ΔGD2JPP = 46,59 ± 80,32; p = 0,084). Following HbA1c, there were also observed an insignificant decrease of PSS in LPD group compared to control group (ΔPSS = -5.09 ± 6.47; p = 0.655).

Conclusion. Therapy with LPD decreases HOMA-IR, improves glycemic control (HbA1c) and reduces stress levels in diabetic patients without depression, but is not statistically significant.






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Journal of the Medical Sciences (Berkala Ilmu Kedokteran) by  Universitas Gadjah Mada is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Based on a work at http://jurnal.ugm.ac.id/bik/.