The analysis of cell damage of liver and kidney among alcoholics in Yogyakarta, Indonesia

https://doi.org/10.19106/JMedSci005103201908

S Suhartini(1*), Hendro Widagdo(2), Yudha Nurhantari(3), Idha Arfianti Wiraagni(4)

(1) Department of Forensic Medicine and Medicolegal, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta
(2) Department of Forensic Medicine and Medicolegal, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta
(3) Department of Forensic Medicine and Medicolegal, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta
(4) Department of Forensic Medicine and Medicolegal, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta
(*) Corresponding Author

Abstract


Alcohol tends to disrupt the organs function of human body, even can cause serious and chronic damage. In Indonesia, the data on cell damage taken from organs including the livers and kidneys among alcoholics are still practically unknown. The aim of this study was to compare the differences of organs’ cell disturbance between alcoholics and non-alcoholics in Yogyakarta, Indonesia. A crosssectional study was conducted among 197 people in Yogyakarta, including 96 alcoholics and 101 non-alcoholics. The material of the study was taken from venous blood samples. A kinetic photometric test was conducted to obtain data on blood-chemical markers’ value of livers (SGOT, SGPT, and GGT), and kidneys (BUN and serum creatinine). The data werethen analyzed by Chi square test.From a total of 96 alcoholics, 83.6% are males and 16.4% are females who consumed alcohol for an average of 16 years, with 51.6% routinely consuming it daily. The kind of alcohol they consumed was single-brand (59.8%). Based on 25th percentile (GGT), on 50th percentile (SGOT, GGT), and on 75th percentile (SGPT, GGT), the alcoholics had higher proportion value of liver marker disturbance than non-alcoholics which was statistically significant (p<0.05). Based on the 50th and 75th percentiles, the alcoholics also had higher proportion value on kidney marker (BUN) damage than non-alcoholics which was statistically significant (p<0.05). There were significant differences in GFR values between males and females (p<0.05), males had kidney cell damage 7.9 times more than females. There was no significant difference in the value of GFR between alcoholics and non-alcoholics. In conclusion, the alcoholics hassignificantly higher proportion value of blood-chemical markers than that non-alcoholics. The GFR values between males and females are also significantly different, and males had kidney cell damage 7.9 times more than that of females.


Keywords


alcohol; liver; kidney cell damage

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References

  1. World Health Organization. Indonesia socio economic context. Accessed March 3, 2014. http://www,who,int/substance_abuse/publications/global_alcohol_report/profiles/idn,pdf
  2. Moss M, Burnham EL. Alcohol abuse in the critically ill patient. Lancet 2006; 368(9554):2231-42. https://doi.org/10.1016/S0140-6736(06)69490-7
  3. Ismail MK, Riely C. Alcoholic fatty liver. Medicine from WebMD, 2006 October 31. http://www.emedicine,com/med/topic99.htm
  4. World Health Organization. The global status report on alcohol and health. Geneva: WHO Library Cataloguing-in-Publication Data, 2014.
  5. O’Shea RS, Dasarathy S, McCullough AJ. Overview alcoholic liver disease. Am J Gastroenterol 2010; 105(1):14-32. https://doi.org/10.1038/ajg.2009.593
  6. Hieda Y, Takeshita H, Fujihara J, Takayama K. A fatal case of pure ethanol ingestion. Forensic Sci Int 2005; 149(2-3):243-7. https://doi.org/10.1016/j.forsciint.2004.08.011
  7. Berg JM, Tymoczko JL, Stryer L. Biochemistry, 5th ed.New York: WH Freeman, 2002.
  8. Anonymous. Insert Kit GOT (ASAT). Jakarta: PT. Rajawali Nusindo, 2008.
  9. Basic Medical Research (Riskesdas). Medical research and development institution. Jakarta: Department of Health, Republic of Indonesia 2007.
  10. Perpres RI. Peraturan Presiden Republik Indonesia nomor 74 tahun 2013 tentang pengendalian dan pengawasan minuman beralkohol, Jakarta: Presiden RI, 2013.
  11. Stephen R. Investigating abnormal liver function tests. Nottingham: Queens Medical Centre, Nottingham University Hospitals NHS Trust, 2013.
  12. Allen JP, Litten RZ, Anton RF, Cross GM. Carbohydrate-deficient transferrin as a measure of immoderate drinking: remaining issues. Alcohol Clin Exp Res 1994; 18(4):799-812. https://doi.org/10.1111/j.1530-0277.1994.tb00043.x
  13. Niemela O. Biomarkers in alcoholism. Clin Chim Acta 2007; 377(1-2):39-49. https://doi.org/10.1016/j.cca.2006.08.035
  14. Somba IM. Analisis status fungsi ginjal mantan penyalahguna narkotika psikotropika dan zat adiktif (NAPZA) di Pusat Rehabilitasi Yayasan Al Islami, Pondok Pesantren Nurul Haromain Kulonprogo, Pondok Rehabilitasi Tetirah Dzikir, dan RS Grhasia. Yogyakarta; Fakultas Kedokteran UGM 2013.
  15. World Health Organization. The global status report on alcohol. Profile: South East Asia. Geneva: WHO Press, 2004.
  16. Epstein M. Alcohol’s impact on kidney function. Alcohol Health Res World 1997; 21(1):84-92.
  17. Anonim. eGFR calculator-U kidney’s nephrology community. Internet School of Nephrology, 2019. https://ukidney.com/nephrology-resources/egfr-calculator
  18. Chung FM, Yang YH, Shieh TY, Shin SJ, Tsai JC, Lee YJ. Effect of alcohol consumption on estimated glomerular filtration rate and creatinine clearance rate. Nephrol Dial Transplant 2005; 20(8):1610-6. https://doi.org/10.1093/ndt/gfh842



DOI: https://doi.org/10.19106/JMedSci005103201908

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