gwenny Ichsan Prabowo
* Corresponding Author Departement of Biochemistry, Medicine Faculty, Universitas Airlangga, Surabaya, Indonesia
Medical Biochemistry
Margarita Maria Maramis Department of Psychiatry, Dr. Soetomo General Hospital Surabaya
Erikavitri Yulianti Department of Psychiatry, Dr. Soetomo General Hospital Surabaya
Afrina Zulaikah Department of Psychiatry, Dr. Soetomo General Hospital Surabay
Zain Budi Syulthoni Department of Psychiatry, Dr. Soetomo General Hospital Surabaya
Hendy Muagiri Margono Department of Psychiatry, Dr. Soetomo General Hospital Surabaya
Retno Handajani Departement of Biochemistry, Medicine Faculty, Universitas Airlangga, Surabaya,
Institute of Tropical Disease, Universitas Airlangga,Surabaya, Indonesia
(1) Departement of Biochemistry, Medicine Faculty, Universitas Airlangga, Surabaya, (2) Department of Psychiatry, Dr. Soetomo General Hospital Surabaya (3) Department of Psychiatry, Dr. Soetomo General Hospital Surabaya (4) Department of Psychiatry, Dr. Soetomo General Hospital Surabay (5) Department of Psychiatry, Dr. Soetomo General Hospital Surabaya (6) Department of Psychiatry, Dr. Soetomo General Hospital Surabaya (7) Departement of Biochemistry, Medicine Faculty, Universitas Airlangga, Surabaya,
Institute of Tropical Disease, Universitas Airlangga,Surabaya, Indonesia (*) Corresponding Author
Abstract
Schizophrenia is a common health problem in the world, including in Indonesia. Polymorphism of gene disrupted in schizophrenia 1 (DISC1) Leu607Phe is allegedly related to the predisposition to schizophrenia. However, studies on the relationship between polymorphism of DISC1 Leu607Phe and schizophrenia in various etnics provided different results. The purpose of this study was to determine the frequency of DISC1 Leu607Phegene polymorphism and its association with treatment response in patients with schizophrenia at Department of Psychiatry, Dr. Soetomo General Hospital Surabaya. In this study, the number of male patients with schizophrenia was more than that of the female patients. The mean age of male patients with schizophenia was lower than that of the female patients. Schizophrenia patients were primarily came from Javanese ethnic with positive and negative symptom score (PANSS) lower in male patients than that in the female patients. In conclusion, no DISC1 gene polymorphism at codon 607 is observed in schizophrenia patients at Dr. Soetomo General Hospital Surabaya, but the G nucleotide variation at the number 196.339 in intron regions is found instead.
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