Correlation Between Ischemic Time with Kidney Graft Function in Living Donor Kidney Transplant at Sardjito Hospital
Abstract
Background: Kidney transplant function is expected to recover soon after transplantation, marked by decrease in serum creatinine and increase in urine output. Ischemic time is one of the factors that can affect kidney function. Creatinine Reduction Ratio day 2 (CRR2) can graft function
Objective: To know the correlation between ischemic time and early graft function in living donor kidney transplantation, measured by CRR.2.
Methods:This research used a retrospective cohort observational method. Data were collected from medical records of all kidney transplant patients at RSUP Dr. Sardjito from January 2017 to December 2024. The inclusion criteria are patients aged over 18 years, exclusion criteria are patients with hyperacute rejection, recipients lost of data, and those with extreme values. Normality tests using the Kolmogorov-Smirnov test, followed by Spearman correlation analysis. The cutoff for ischemic time was determined based on the highest sensitivity and specificity. The ischemic time and other variables that could affect CRR2 were analyzed bivariately. Variables with p-values < 0.25 are analyzed in multivariate analysis using logistic regression with backward method to identify variables influencing kidney transplant function.
Results: The total procedures was 91 samples, of which 82 patients met the inclusion criteria. One patient was excluded due to hyperacute rejection, six patients had no ischemic time data, and two patients were outliers. From the 82 samples, the average age was 38.65 ± 12.34 years, with 75.6% male and 24.4% female. The average BMI was 23.64 ± 4.7
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