Efek pemakaian bisphosphonate pada pergerakan gigi ortodonti

Dini Anggraini; Haru Setyo Anggani

doi:10.22146/mkgk.31979

Efek pemakaian bisphosphonate pada pergerakan gigi ortodonti

https://doi.org/10.22146/mkgk.31979

Dini Anggraini^(1*), Haru Setyo Anggani⁽²⁾

(1) Program Studi Spesialis Ortodonsi, Fakultas Kedokteran Gigi, Universitas Indonesia, Jakarta, Indonesia
(2) Departemen Ortodonsi, Fakultas Kedokteran Gigi, Universitas Indonesia, Jakarta, Indonesia
(*) Corresponding Author

Abstract

Pergerakan gigi penjangkaran yang tidak diinginkan atau relaps gigi-geligi paska perawatan ortodonti, merupakan salah satu efek samping yang tidak diharapkan. Berbagai alat mekanik ortodonti telah digunakan guna mencegah hilangnya penjangkaran, baik alat ekstra oral dan intra oral. Namun, pada penggunaan alat-alat ini masih dijumpai kehilangan penjangkaran dan menimbulkan efek-efek samping seperti resorpsi akar, lesi white spot, karies, gingivitis dan sebagainya.Selain alat mekanik, agen farmakologi juga potensial untuk menyediakan penjangkaran. Agen farmakologi terbaru yang dapat menghambat pergerakan gigi ortodonti adalah Bisphosphonate. Penulis melakukan studi literatur ini guna mengetahui lebih jauh tentang senyawa Bisphosphonate dan efek farmakodinamik serta farmakokinetiknya sehingga mungkin dapat dijadikan sebagai agen farmakologi guna menghambat pergerakan gigi ortodonti. Hasil penelusuran pada berbagai pustaka menunjukkan bahwa Bisphosphosphonate dapat menghambat pergerakan gigi ortodonti. Temuan ini membuka peluang penggunaan Bisphosphonate guna menambah sifat penjangkaran pada perawatan ortodonsi. Namun perlu penelitian lebih lanjut, agar senyawa ini dapat digunakan secara klinik untuk menghambat pergerakan gigi ortodonti.

ABSTRACT: Effect of bisphosphonate administrations on orthodontic tooth movement. Undesirable movement of anchorage tooth or dental relapse of the moved tooth to its initial position after orthodontic treatment are the some unexpected side effects. Various mechanical appliances have been used to prevent anchorage loss, both extra oral and intra oral appliance. However, even with the use of all of these appliances, anchorage loss and other unexpected side effects such as root resorption, white spot lesion, caries, gingivitis, etc were still can be found. Besides mechanical appliances, pharmacological agent also has potential to provide anchorage. The most recent pharmacological agent that can prevent orthodontic tooth movement is Bisphosphonate. The author conduct this literature study in order to have further understanding about bisphosphonate and its pharmacodynamics and pharmacokinetics effects as pharmacological agent to hamper orthodontic tooth movements. Literature studies from numerous references show that Bisphosphonate can prevent orthodontic tooth movement.This finding opens the opportunity of Bisphosphonate administration in order to increase anchorage properties during orthodontic treatment. However, the use of Bisphosphonate clinically to prevent orthodontic tooth movement still require further research.

Keywords

bisphosphonate, perawatan ortodonti, pergerakan gigi, bisphosphonate, orthodontic treatment, tooth movement

Full Text:

PDF

References

1. Proffit WR. Contemporary Orthodontics. 5th ed. Missouri: Elsevier Mosby; 2013. 278 – 290.

2. Fujimura Y, Kitaura H, Yoshimatsu M, et al. Influence of bisphosphonates on orthodontic tooth movement in mice. Eur J Orthod. 2009; 31(6): 572 – 577.

3. Vanarsdall G. Orthodontics current principles and techniques. 5th ed. Philadelphia: Elsevier Mosby; 2012. 253 – 262.

4. Igarashi K, Mitani H, Adachi H, Shinoda H. Anchorage and retentive effects of a bisphosphonate (AHBuBP) on tooth movements in rats. Am J Orthod Dentofacial Orthop. 1994; 106(3): 279 – 289.

5. Ortega AJ a J, Campbell PM, Hinton R, Naidu A, Buschang PH. Local application of zoledronate for maximum anchorage during space closure. Am J Orthod Dentofacial Orthop. 2012; 142(6): 780 – 791.

6. Iglesias-Linares A, Yáñez-Vico R-M, Solano-Reina E, Torres-Lagares D, González Moles MA. Influence of bisphosphonates in orthodontic therapy: Systematic review. J Dent. 2010; 38(8): 603 – 611.

7. Russel RG., Watts N., Ebetino F. Mechanisms of action of bisphosphonates: similarities and differences and their potential influence on clinical efficacy. Osteoporos Int. 2008; 19(6): 733 – 759.

8. Jimi E, Takami M, Hiraga T, Nakamura I, Urade M, Miyamoto Y. The Light and Dark Side of Bisphosphonates. J Oral Biosci. 2009; 51(4): 177 – 187.

9. Papapoulos SE. Bisphosphonates : how do they work ? Best Pract Res Clin Endocrinol Metab. 2008; 22(5): 831 – 847.

10. Dunford JE, Thompson K, Coxon FP, et al. Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates. J Pharmacol Exp Ther. 2001; 296(2): 235 – 242.

11. Russell RGG. Bisphosphonates : Mode of Action and Pharmacology. Pediatrics. 2014; 119(2): 150 – 162.

12. Zahrowski JJ. Bisphosphonate treatment: an orthodontic concern calling for a proactive approach. Am J Orthod Dentofacial Orthop. 2007; 131(3): 311 – 320.

13. Bartzela T, Türp JC, Motschall E, Maltha JC. Medication effects on the rate of orthodontic tooth movement: a systematic literature review. Am J Orthod Dentofacial Orthop. 2009; 135(1): 16 – 26.

14. Altundal H. The effect of alendronate on resorption of the alveolar bone following tooth extraction. Int J Oral Maxillofac Surg. 2004; 33: 286 – 293.

15. Kaipatur NR, Wu Y, Adeeb S, Stevenson TR, Major PW, Doschak MR. Impact of bisphosphonate drug burden in alveolar bone during orthodontic tooth movement in a rat model: a pilot study. Am J Orthod Dentofacial Orthop. 2013; 144(4): 557 – 567.

16. Lotwala RB, Greenlee GM, Ott SM, Hall SH, Huang GJ. Bisphosphonates as a risk factor for adverse orthodontic outcomes: a retrospective cohort study. Am J Orthod Dentofacial Orthop. 2012; 142(5): 625 – 634.

17. Adachi H, Igarashi K, Mitani H, Shinoda H. Effects of topical administration of a bisphosphonate (risedronate) on orthodontic tooth movements in rats. J Dent Res. 1994; 73(8): 1478 – 1486.

18. Lee K, Sugiyama H, Imoto S, Tanne K. Effects of bisphosphonate on the remodeling of rat sagittal suture after rapid expansion. Angle Orthod. 2001; 71(4): 265 – 273.

19. Kim TW, Yoshida Y, Yokoya K, Sasaki T. An ultrastructural study of the effects of bisphosphonate administration on osteoclastic bone resorption during relapse of experimentally moved rat molars. Am J Orthod Dentofacial Orthop. 1999; 115(6): 645–53.

20. Sato Y, Sakai H, Kobayashi Y, Shibasaki Y, Sasaki T. Bisphosphonate administration alters subcellular localization of vacuolar-yype H ؉ -ATPase and cathepsin K in osteoclasts during experimental movement of rat molars. Anat Rec. 2000; 80(February): 72 – 80.

21. Liu L, Igarashi K, Haruyama N, Saeki S, Shinoda H, Mitani H. Effects of local administration of clodronate on orthodontic tooth movement and root resorption in rats. Eur J Orthod. 2004; 26(5): 469 – 473.

22. Choi J, Baek S-H, Lee J-I, Chang Y-I. Effects of clodronate on early alveolar bone remodeling and root resorption related to orthodontic forces : a histomorphometric analysis. Am J Orthod Dentofac Orthop. 2010; 138(5): 548 – 549.

23. Karras JC, Miller JR, Hodges JS, Beyer JP, Larson BE. Effect of alendronate on orthodontic tooth movement in rats. Am J Orthod Dentofacial Orthop. 2009; 136(6): 843–7.

24. Ozturk F, Hasan B, Sevinc I, Gumus C. Effects of bisphosphonates on sutural bone formation and relapse: A histologic and immunohistochemical study. Am J Orthod Dentofacial Orthop. 2011; 140: 31 – 41.

25. Sirisoontorn I, Hotokezaka H, Hashimoto M, et al. Orthodontic tooth movement and root resorption in ovariectomized rats treated by systemic administration of zoledronic acid. Am J Orthod Dentofacial Orthop. 2012; 141(5): 563 – 573.

26. Keles A, Grunes B, Difuria C, et al. Inhibition of tooth movement by osteoprotegerin vs. pamidronate under conditions of constant orthodontic force. Eur J Oral Sci. 2007; 115(2): 131 – 136.

27. Wood J, Bonjean K, Ruetz S, et al. Novel Antiangiogenic Effects of the Bisphosphonate Compound Zoledronic Acid. J Pharmacol Exp Ther. 2002; 302(3): 1055 – 1061.

28. Fournier P, Boissier S, Filleur S, Guglielmi J, Cabon F, Colombel M. Bisphosphonates Inhibit Angiogenesis in Vitro and Testosterone-stimulated Vascular Regrowth in the Ventral Prostate in Castrated Rats. Cancer Res. 2002; 62: 6538 – 6544.

29. Peterson DE, Ph D, Seneda LM. Bisphosphonate-Associated Osteonecrosis of Mandibular and Maxillary Bone An Emerging Oral Complication of Supportive Cancer Therapy. Am Cancer Soc. 2005; 104: 83 – 93.

30. Khosla S, Burr D, Cauley J, et al. Bisphosphonate-Associated Osteonecrosis of the Jaw: Report of a Task Force of the American Society for Bone and Mineral Research. 2007; 22(10): 10 - 5.

31. Rinchuse DJ, Rinchuse DJ, Sosovicka MF, Robison JM, Pendleton R. bisphosphonates : A report of 2 cases. Am J Orthod Dentofac Orthop. 2007; 131: 321 – 326.

DOI: https://doi.org/10.22146/mkgk.31979