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* Corresponding Author
Efek pemakaian bisphosphonate pada pergerakan gigi ortodonti
https://doi.org/10.22146/mkgk.31979 Dini Anggraini(1*), Haru Setyo Anggani(2)
(1) Program Studi Spesialis Ortodonsi, Fakultas Kedokteran Gigi, Universitas Indonesia, Jakarta, Indonesia
(2) Departemen Ortodonsi, Fakultas Kedokteran Gigi, Universitas Indonesia, Jakarta, Indonesia
(*) Corresponding Author
Abstract
Pergerakan gigi penjangkaran yang tidak diinginkan atau relaps gigi-geligi paska perawatan ortodonti, merupakan salah satu efek samping yang tidak diharapkan. Berbagai alat mekanik ortodonti telah digunakan guna mencegah hilangnya penjangkaran, baik alat ekstra oral dan intra oral. Namun, pada penggunaan alat-alat ini masih dijumpai kehilangan penjangkaran dan menimbulkan efek-efek samping seperti resorpsi akar, lesi white spot, karies, gingivitis dan sebagainya.Selain alat mekanik, agen farmakologi juga potensial untuk menyediakan penjangkaran. Agen farmakologi terbaru yang dapat menghambat pergerakan gigi ortodonti adalah Bisphosphonate. Penulis melakukan studi literatur ini guna mengetahui lebih jauh tentang senyawa Bisphosphonate dan efek farmakodinamik serta farmakokinetiknya sehingga mungkin dapat dijadikan sebagai agen farmakologi guna menghambat pergerakan gigi ortodonti. Hasil penelusuran pada berbagai pustaka menunjukkan bahwa Bisphosphosphonate dapat menghambat pergerakan gigi ortodonti. Temuan ini membuka peluang penggunaan Bisphosphonate guna menambah sifat penjangkaran pada perawatan ortodonsi. Namun perlu penelitian lebih lanjut, agar senyawa ini dapat digunakan secara klinik untuk menghambat pergerakan gigi ortodonti.
ABSTRACT: Effect of bisphosphonate administrations on orthodontic tooth movement. Undesirable movement of anchorage tooth or dental relapse of the moved tooth to its initial position after orthodontic treatment are the some unexpected side effects. Various mechanical appliances have been used to prevent anchorage loss, both extra oral and intra oral appliance. However, even with the use of all of these appliances, anchorage loss and other unexpected side effects such as root resorption, white spot lesion, caries, gingivitis, etc were still can be found. Besides mechanical appliances, pharmacological agent also has potential to provide anchorage. The most recent pharmacological agent that can prevent orthodontic tooth movement is Bisphosphonate. The author conduct this literature study in order to have further understanding about bisphosphonate and its pharmacodynamics and pharmacokinetics effects as pharmacological agent to hamper orthodontic tooth movements. Literature studies from numerous references show that Bisphosphonate can prevent orthodontic tooth movement.This finding opens the opportunity of Bisphosphonate administration in order to increase anchorage properties during orthodontic treatment. However, the use of Bisphosphonate clinically to prevent orthodontic tooth movement still require further research.
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DOI: https://doi.org/10.22146/mkgk.31979
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