Hubungan Penggantian Nama Dagang Asam Valproat dengan Luaran Klinik Pasien Pediatrik Penderita Epilepsi di Instalasi Rawat Jalan RSUD Panembahan Senopati Bantul Yogyakarta

Ania Rachma Apriani; Rizaldy Taslim Pizon; Zulies Ikawati

doi:10.22146/farmaseutik.v19i1.75283

Hubungan Penggantian Nama Dagang Asam Valproat dengan Luaran Klinik Pasien Pediatrik Penderita Epilepsi di Instalasi Rawat Jalan RSUD Panembahan Senopati Bantul Yogyakarta

https://doi.org/10.22146/farmaseutik.v19i1.75283

Ania Rachma Apriani⁽¹⁾, Rizaldy Taslim Pizon^(2*), Zulies Ikawati⁽³⁾

(1) Universitas Gadjah Mada (UGM)
(2) Fakultas Farmasi Universitas Gadjah Mada
(3) Fakultas Farmasi Universitas Gadjah Mada
(*) Corresponding Author

Abstract

Epilepsi merupakan penyakit kronis yang memerlukan perhatian dalam pelayanan kesehatan, karena penggunaannya yang bersifat jangka panjang. Obat Anti Epilepsi (OAE) mempunyai rentang terapi yang sempit, sehingga dalam penatalaksanaan terapinya membutuhkan perhatian, termasuk dalam hal penggantian atau substitusi obatnya. Asam valproat merupakan OAE yang sering digunakan pada pasien pediatrik penderita epilepsi di Instalasi Rawat Rawat Jalan Anak RSUD Panembahan Senopati Bantul Yogyakarta. Tujuan penelitian adalah untuk mengukur hubungan antara penggantian nama dagang asam valproat dengan luaran klinik berupa bangkitan epilepsi pada pasien pediatrik tersebut. Penelitian ini merupakan penelitian dengan rancangan Cohort Study yang dilakukan secara retrospektif, dan dilakukan di RSUD Panembahan Senopati Bantul. Instrumen penelitian berupa aplikasi SIM-RS dan data rekam medik pasien. Pada aplikasi SIM-RS diperoleh data berupa nama dagang asam valproat yang digunakan oleh pasien selama 3 bulan pada periode kunjungan bulan Januari 2020 sampai dengan Desember 2020, kemudian diikuti dan diamati pada bulan ketiga pengamatan. Analisis data yang digunakan untuk mengetahui pengaruh penggantian nama dagang asam valproat ini adalah menggunakan SPSS dengan uji independent t-test dan analisis kovarian digunakan untuk mengetahui seberapa besar faktor klinik berpengaruh pada luaran klinik pasien tersebut. Hasil penelitan ini menunjukkan tidak adanya hubungan antara penggantian nama dagang asam valproat dengan luaran klinik berupa bangkitan epilepsi pada pasien pediatrik penderita epilepsi di Instalasi Rawat Rawat Jalan Anak RSUD Panembahan Senopati Bantul Yogyakarta.

Keywords

asam valproat; bangkitan epilepsi; nama dagang; pediatrik

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References

Al-Balawi, R.S., 2020. Measuring the appropriateness of carbamazepine and valproic acid prescribing and utilization using a newly implemented online system in the Tabuk Region of Saudi Arabia. Saudi Pharmaceutical Journal, 6.

Al-Balawi, R.S., Alshehri, M.A., Alatawi, A.S., Al Shehri, A.M., Alshehry, M.A., dan Al- Gayyar, M.M.H., 2020. Measuring the appropriateness of carbamazepine and valproic acid prescribing and utilization using a newly implemented online system in the Tabuk Region of Saudi Arabia. Saudi Pharmaceutical Journal, 28: 844–849.

Atif, Muhammad, dkk. 2016. Potensial Problems and Recommendation Regarding Subtitution of Generic Epileptic Drugs : a Sistematic Review of Literature

Boon, P., Ferrao Santos, S., Jansen, A.C., Lagae, L., Legros, B., dan Weckhuysen, S., 2021. Recommendations for the treatment of epilepsy in adult and pediatric patients in Belgium: 2020 update. Acta Neurologica Belgica, 121: 241–257.

Bosak, Magdalena, dkk. 2017. Safety of Switching from Nama dagang Name to Generic Levetiracetam in Patient with Epilepsy

Cai Q-Y, Zhou Z-J, Luo R, Gan J, Li S-P, Mu D-Z, dkk.. Safety and tolerability of the ketogenic diet used for the treatment of refractory childhood epilepsy: a systematic review of published prospective studies. World J Pediatr [Internet]. 2017 Dec 12 [cited 2021 Apr 3];13(6):528–36. Available from: http://link.springer.com/10.1007/s12519-017-0053-2

Camfield P, Camfield C, dan Pohlmann-Eden B. 2012. Transition From Pediatric to Adult Epilepsy Care: A Difficult Process Marked by Medical and Social Crisis. American Epilepsy Society. 13–21.

Chisholm, MA ST. 2016. Pharmacotherapy Principles and Practice. New York: Mc Graw- Hill Companies.

Coste, J., Blotiere, P.-O., Miranda, S., Mikaeloff, Y., Peyre, H., Ramus, F., dkk., 2020a. Risk of early neurodevelopmental disorders associated with in utero exposure to

valproate and other antiepileptic drugs: a nationwide cohort study in France. Scientific Reports, 10: 17362.

Coste, J., Blotiere, P.-O., Miranda, S., Mikaeloff, Y., Peyre, H., Ramus, F., dkk., 2020b. Risk of early neurodevelopmental disorders associated with in utero exposure to valproate and other antiepileptic drugs: a nationwide cohort study in France. Scientific Reports, 10: 17362.

Dijkman SC, Alvarez-Jimenez R, Danhof M, Pasqua OD. 2016. Pharmacotherapy in pediatric epilepsy : from trial and error to rational drug and dose selection-a long way to go. Expert Opinion on Drug Metabolism and Toxicology;12:1143-56.

Finamore, J.M., Sperling, M.R., Zhan, T., Nei, M., Skidmore, C.T., dan Mintzer, S., 2016. Seizure outcome after switching antiepileptic drugs: A matched, prospective study. Epilepsia, 57: 1294–1300.

Fisher RS, Cross JH, D’Souza C, French JA, Haut SR, Higurashi N, dkk.. Instruction manual for the ILAE 2017 operational classification of seizure types. Epilepsia [Internet]. 2017 Apr 1 [cited 2021 Mar 24];58(4):531–42. Available from: http://doi.wiley.com/10.1111/epi.13671

Goel, D. dan Mittal, M., 2021. Experience with Low-Dose Sodium Valproate in Idiopathic Generalized Epilepsy Patients: A Long-Term Follow-Up Study on Selective Cohort from North India. Journal of Neurosciences in Rural Practice, 12: 046–050.

Keputusan Menteri Kesehatan Republik Indonesia Nomor HK.01.07/ Menkes/367/2017 Tentang Pedoman Nasional Pelayanan Kedokteran Tata Laksana Epilepsi pada Anak

Kemenkes RI. Peraturan Menteri Kesehatan Republik Indonesia Nomor 72 Tahun 2016 Tentang Standar Pelayanan Kefarmasian. 2016.

NICE. 2018. Epilepsies : Diagnosis and Management. Epilepsies. CG137. pp. 1-99 Penovich, P.E., Stern, J.M., Becker, D.A., Long, L., Santilli, N., McGuire, L., dkk., 2021.

Epilepsy Treatment Complacency in Patients, Caregivers, and Healthcare Professionals. Neurology: Clinical Practice,10.1212/CPJ.0000000000001066.

PERDOSSI. 2016. Pedoman Tatalaksana Epilepsi. Airlangga University Press.

Surabaya.

Pressler, R.M., Cilio, M.R., Mizrahi, E.M., Moshé, S.L., Nunes, M.L., Plouin, P., dkk., 2021. The ILAE classification of seizures and the epilepsies: Modification for seizures in the neonate. Position paper by the ILAE Task Force on Neonatal Seizures. Epilepsia, 62: 615–628.

Scheffer, I.E., Berkovic, S., Capovilla, G., Connolly, M.B., French, J., Guilhoto, L., dkk., 2017. ILAE classification of the epilepsies: Position paper of the ILAE Commission for Classification and Terminology. Epilepsia, 58: 512–521.

Shin, Jung-Wong, dkk. 2017. Switching between Phenytoin Generics in Patient with Epilepsy may Lead to Increased Risk of Breakthrough Seizure : Chart Analysis and Practice Recommendations

Sinaga N. 2018. Artikel Penelitian : Dosis Obat Anti epilepsi pada Respons Awal Pengobatan Epilepsi Dose of Antiepileptic Drugs in Initial Response to Epilepsy Treatment ; 3(3):163–73.

DOI: https://doi.org/10.22146/farmaseutik.v19i1.75283