Outpatient Parenteral Antimicrobial Treatment Pada Pasien Ulkus Diabetik di RSUP Dr. Sardjito Yogyakarta: Kajian Clinical Outcome Dan Kualitas Hidup Pasien
Rizki Rahmawati(1), Ika Puspitasari(2*), Rizka Humardewayanti Asdie(3), Hemi Sinorita(4)
(1) Magister Farmasi Klinik, Fakultas Farmasi, Universitas Gadjah Mada
(2) Faculty of Pharmacy, Universitas Gadjah Mada
(3) Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran, Kesehatan Masyarakat dan Keperawatan Universitas Gadjah Mada/ RSUP Dr. Sardjito, Yogyakarta
(4) Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran, Kesehatan Masyarakat dan Keperawatan Universitas Gadjah Mada/ RSUP Dr. Sardjito, Yogyakarta
(*) Corresponding Author
Abstract
Outpatient parenteral antimicrobial treatment (OPAT) adalah metode untuk memberikan antibiotik intravena di komunitas atau rawat jalan sebagai alternatif untuk perawatan rawat inap. Tujuan utama program OPAT adalah memungkinkan pasien memperoleh terapi antibiotik parenteral dengan aman dan efektif tanpa menjalani rawat inap. Penelitian ini bertujuan untuk mengetahui pengaruh clinical outcome terhadap kualitas hidup pada pasien ulkus diabetik terinfeksi yang mendapatkan pelayanan OPAT dan rawat inap. Penelitian ini adalah penelitian kuasi ekperimental dengan pendekatan prospektif pada pasien ulkus diabetik di RSUP Dr. Sardjito. Pengambilan sampel dilakukan secara non probability sampling kuota yang dilakukan pada bulan September 2019 – September 2020. Clinical outcome dinilai dari skor PEDIS yang kemudian di kategorikan membaik atau tidak membaik. Kuisoner SF-36 digunakan dalam penilaian kualitas hidup pasien. Uji t tidak berpasangan dan Mann Whitney dilakukan untuk mengetahui perbedaan clinical outcome serta Uji Fisher exact test dilakukan untuk mengetahui ada tidaknya pengaruh antara clinical outcome terhadap kualitas hidup pasien. Subjek penelitian dalam penelitian ini sebanyak 30 pasien yang terdiri dari kelompok OPAT dan kelompok rawat inap. Hasil yang didapatkan pada penelitian ini yaitu sebanyak 93% pasien OPAT membaik, dan 100% pasien Rawat Inap membaik. Tidak terdapat pengaruh yang significant antara clinical outcome dengan kualitas hidup pada pasien ulkus kaki diabetik di RSUP Dr. Sardjito Yogyakarta.
Keywords
Full Text:
PDFReferences
Agale, S. V. (2013). Chronic Leg Ulcers: Epidemiology, Aetiopathogenesis, and Management. Ulcers, 2013, 1–9. https://doi.org/10.1155/2013/413604
Alosaimi, F. D., Labani, R., Almasoud, N., Alhelali, N., Althawadi, L., & Aljahani, D. M. (2019). Associations of foot ulceration with quality of life and psychosocial determinants among patients with diabetes; A case-control study. Journal of Foot and Ankle Research, 12(1), 1–11. https://doi.org/10.1186/s13047-019-0367-5
Alrub, A. A., Hyassat, D., Khader, Y. S., Bani-Mustafa, R., Younes, N., & Ajlouni, K. (2019). Factors associated with health-related quality of life among Jordanian patients with diabetic foot ulcer. Journal of Diabetes Research, 2019. https://doi.org/10.1155/2019/4706720
Anderson, K., & Hamm, R. L. (2012). Factors that impair wound healing. In Journal of the American College of Clinical Wound Specialists. https://doi.org/10.1016/j.jccw.2014.03.001
Asharib Arshad, M., Arshad, S., Arshad, S., & Abbas, H. (2020). The Quality of Life in Patients with Diabetic Foot Ulcers. Journal of Diabetes & Metabolism, 11(2), 1–2. https://doi.org/10.35248/2155-6156.20.11.e101
Borji, M., Otaghi, M., & Kazembeigi, S. (2017). The impact of Orem’s self-care model on the quality of life in patients with type II diabetes. Biomedical and Pharmacology Journal, 10(1), 213–220. https://doi.org/10.13005/bpj/1100
Bradbury, S., & Price, P. (2011). The impact of diabetic foot ulcer pain on patient quality of life. Wounds UK.
C.A., A., A.L., C., H., A., S., B., L.C., E., J., G., A.W., H., A., H., N., J., K.E., J., C.H., R., R., T., E.R.E., V. R., A.M., W., P., W., S., W., & A.J.M., B. (2002). The North-West Diabetes Foot Care Study: Incidence of, and risk factors for, new diabetic foot ulceration in a community-based patient cohort. In Diabetic Medicine.
Chapman, A. L. N., Dixon, S., Andrews, D., Lillie, P. J., Bazaz, R., & Patchett, J. D. (2009). Clinical efficacy and cost-effectiveness of outpatient parenteral antibiotic therapy (OPAT): A UK perspective. Journal of Antimicrobial Chemotherapy, 64(6), 1316–1324. https://doi.org/10.1093/jac/dkp343
Ghobadi, A., Sarbarzeh, P. A., Jalilian, M., Abdi, A., & Manouchehri, S. (2020). Evaluation of factors affecting the severity of diabetic foot ulcer in patients with diabetes referred to a diabetes centre in Kermanshah. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 13, 693–703. https://doi.org/10.2147/DMSO.S242431
Guo, S., & DiPietro, L. A. (2010). Factors Affecting Wound Healing REVIEW. Journal of Dental Research.
Kalaivani, V. (2014). Evaluation of diabetic foot complications according to Amit Jain’s classification. Journal of Clinical and Diagnostic Research, 8(12), NC07–NC09. https://doi.org/10.7860/JCDR/2014/10391.5303
Macioch, T., Sobol, E., Krakowiecki, A., Mrozikiewicz-Rakowska, B., Kasprowicz, M., & Hermanowski, T. (2017). Health related quality of life in patients with diabetic foot ulceration - translation and Polish adaptation of Diabetic Foot Ulcer Scale short form. Health and Quality of Life Outcomes. https://doi.org/10.1186/s12955-017-0587-y
Mackintosh, C. L., White, H. A., & Seaton, R. A. (2011). Outpatient parenteral antibiotic therapy (OPAT) for bone and joint infections: Experience from a UK teaching hospital-based service. Journal of Antimicrobial Chemotherapy, 66(2), 408–415. https://doi.org/10.1093/jac/dkq445
Prompers, L., Schaper, N., Apelqvist, J., Edmonds, M., Jude, E., Mauricio, D., Uccioli, L., Urbancic, V., Bakker, K., Holstein, P., Jirkovska, A., Piaggesi, A., Ragnarson-Tennvall, G., Reike, H., Spraul, M., Van Acker, K., Van Baal, J., Van Merode, F., Ferreira, I., & Huijberts, M. (2008). Prediction of outcome in individuals with diabetic foot ulcers: Focus on the differences between individuals with and without peripheral arterial disease. The EURODIALE Study. Diabetologia. https://doi.org/10.1007/s00125-008-0940-0
Psaltikidis, E. M., Silva, E. N. d., Bustorff-Silva, J. M., Moretti, M. L., & Resende, M. R. (2017). Economic evaluation of outpatient parenteral antimicrobial therapy: a systematic review. In Expert Review of Pharmacoeconomics and Outcomes Research. https://doi.org/10.1080/14737167.2017.1360767
Richard, J.-L. (2011). New insights in diabetic foot infection. World Journal of Diabetes, 2(2), 24. https://doi.org/10.4239/wjd.v2.i2.24
Soelistijo, S. A., Novida, H., Rudijanto, A., Soewondo, P., Suastika, K., Manaf, A., Sanusi, H., Lindarto, D., Shahab, A., Pramono, B., Langi, Y. A., Purnamasari, D., Soetedjo, N. N., Saraswati, M. R., Dwipayana, M. P., Yuwono, A., Sasiarini, L., Sugiarto, Sucipto, K. W., & Zufry, H. (2015). Konsensus Pengendalian dan Pencegahan Diabetes Melitus Tipe 2 di Indonesia 2015. In Perkeni. https://doi.org/10.1017/CBO9781107415324.004
Suleyman, G., Kenney, R., Zervos, M. J., & Weinmann, A. (2017). Safety and efficacy of outpatient parenteral antibiotic therapy in an academic infectious disease clinic. Journal of Clinical Pharmacy and Therapeutics, 42(1), 39–43. https://doi.org/10.1111/jcpt.12465
Umaroh, N. (2016). EVALUASI PEMBENTUKAN BIOFILM PADA BAKTERI PENYEBAB ULKUS DIABETIK DI POLI KAKI DIABETES RSUP DR. SARDJITO YOGYAKARTA. Gadjah Mada University.
Wahyuni, A. (2016). Senam Kaki Diabetik Efektif Meningkatkan Ankle Brachial Index Pasien Diabetes Melitus Tipe 2. Jurnal Ipteks Terapan, 9(2), 155–164. https://doi.org/10.22216/jit.2015.v9i2.231
Wilson, J. A., & Clark, J. J. (2004). Obesity: impediment to postsurgical wound healing. Advances in Skin & Wound Care, 17(8), 426–435. https://doi.org/10.1097/00129334-200410000-00013
DOI: https://doi.org/10.22146/farmaseutik.v1i1.60616
Article Metrics
Abstract views : 1765 | views : 1394Refbacks
- There are currently no refbacks.