Korelasi Efek Samping Antiepilepsi terhadap Ketaatan Pasien Epilepsi di RSUD Arifin Achmad Provinsi Riau


Fina Aryani(1*), Lovina Aldelyn(2), Ratna Sari Dewi(3), Septi Muharni(4), Husnawati Husnawati(5)

(1) Sekolah Tinggi Ilmu Farmasi Riau, Pekanbaru
(2) Sekolah Tinggi Ilmu Farmasi Riau, Pekanbaru
(3) Sekolah Tinggi Ilmu Farmasi Riau, Pekanbaru
(4) Sekolah Tinggi Ilmu Farmasi Riau, Pekanbaru
(5) Sekolah Tinggi Ilmu Farmasi Riau, Pekanbaru
(*) Corresponding Author


Epilepsy is a disorder that is seen as a symptom due to disruption of electrical activity in the brain caused by various causes. Adherence is an important point in the management of epilepsy and suspected discomfort of side effects is a factor that supports adherence of epilepsy patients. The purpose of this study was to analyze the effect of the occurrence of side effects on the level of adherence in the treatment of epilepsy patients. This research was analytical descriptive observational with cross-sectional study. Data was collected by accidental sampling method by giving questionnaires directly to patients who met the inclusion criteria in Arifin Achmad Hospital of Riau Province. Samples are 31 outpatient epilepsy patients. The results showed that the side effects that often occur are headaches with percentages 38,7% and fatigue are 38.7% and 29% while patients with high adherence are 51.62% and low adherence is 48.38%. The results is no correlation between side effects and adherence of epilepsy patients (p = 0.144 and r = -0.269).


Antiepilepsi; Efek Samping; Epilepsi; Ketaatan; Korelasi; Adherence; Antiepilepsy; Epilepsy; Side Effect

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Ardianysah, M. dan Maretta, D., 2017, Hubungan Antara Ketaatan Minum Obat terhadap Kejadian Remisi pada Epilepsi, Tesis, FKIK UMY: Yogyakarta

Asconape, J., Andrea, D. dan John, D., 2000, Myoclonus Associated with the Use of Gabapentin, Epilepsia, 41(4): 81-479.

Baker, G.A., Jacoby, A., Francis, P. dan Chadwick D.W., 1995, The Liverpool Adverse Events Drug Profile, Epilepsia, 36(3):59.

Baker., Gus A., Ann, Jacoby. dan Deborah, B., 1997, Quality of Life of People with Epilepsy: A European Study, Epilepsia, 38(3): 62-353.

Chesaniuk., Marie., Hyunmi, Choi., Paul, Wicks. dan Gertraud, S., 2014, Epilepsy & Behavior Perceived Stigma and Adherence in Epilepsy: Evidence for a Link and Mediating Processes, Epilepsy & Behavior,

Cunnington, M.C., R Edward, F., Jennifer R.W. dan Annie, G., 2009, Impact of Nonadherence to Antiepileptic Drugs on Health Care Utilization and Costs: Findings from the RANSOM Study, Epilepsia, 50(3): 9-501.

Davis, K.L., Sean, D.L. dan Heather, M.E., 2008, Prevalence and Cost of Nonadherence with Antiepileptic Drugs in an Adult Managed Care Population, Epilepsia, 49(3): 54-446.

Dipiro J.T., Talbert, R.L., Yee, G.C., Matzke, G.R., Wells, B.G. dan Posey L.M., 2008, Pharmacotherapy: a Pathophysiologic Approach Seventh Edition, The McGraw-Hill Companies, New York.

Fadare, O.J., Sunmonu T.A, Bankole, I.A., Adekeye K.A. dan Abubakar, S.A., 2018, Medication Adhrence and Adverst Effect Profile of Antiepileptic Drug in Nigerian Patient With Epilepsy, Neurodegenerative Disease Management :1-12

Fervenza, F.C., Kanakiriya, S., Kunau, R.T., Gibney, R., Lager, D.J., 2000, Acute Granulomatous Interstitial Nephritis and Colitis, American Journal of Kidney Disease, 36(5): 1034-1040.

Gabr, W.M., 2015, Adherence to Medication among Outpatient Adolescents with Epilepsy, Saudi Pharmaceutical Journal, 23(1): 33–40.

Galleli, L., Siniscalchi, A., Russo., De-Sarro, G., 2013, A Review on Antiepileptic Drugs-Dependent Fatigue: Pathophysiological Mechanism and Incidence, Europan Journal of Pharmacology, 718(3): 10-16

Getnet, A., Woldeyohannes, S.M., Bekana., Mekonen, Tesfa., Fekadu, W., Menberu, M., Yimer, S., Assaye, A., Belette, A. dan Belete, H.,2016, Antiepileptic Drug Non-adherence and Its Predictors Among People With Epilepsy, Behavioural Neurology, 1-6

Gofir, A. dan Wibowo, S., 2006, Obat Antiepilepsi, Pustaka Cendikia Press, Yogyakarta.

Gofir, A., Ikawati, Z. dan Wijayatri, R., 2012, Perbandingan Monoterapi dengan Politerapi Pada Epilepsi Jenis Idiophatik Generalised Tonic Clonic, Jurnal Manajeman dan Pelayanan Farmasi, 3(2):93-98

Greene, N.M., C.A, Heath., J, Greene, 2016, A Review of Medication Adherence in People with Epilepsy, Neurologica : 1– 9.

Hesdorffer DC, Benn EK, Bagiella E, Nordli D, Pellock J, Hinton V, Shinnar S; FEBSTAT Study Team. Distribution of febrile seizure duration and associations with development. Ann Neurol. 2011 Jul;70(1):93-100

Hogan, R.E., Mary, E.B., Roger, L.D. dan Kenneth, W.S., 2000, Total Percentage Body Weight Changes during Add-on Therapy with Tiagabine, Carbamazepine and Phenytoin, Epilepsy Research, 41(2000): 23–28.

Huang CW, Tsai JJ, Lai ML. Lamotrigine-related skin rashes in adults. Kaohsiung J Med Sci. 2002 Nov;18(11):566-72

Hussein, A., Amira, A., Faroug, O., Hassan, E., Omer, E.A., Bedraldin, M., Mohmad, M., Iway, I., Yasin, A. dan Esam, M., 2010, Correlation Between Serum Level of Antiepileptic Drugs and Their Side Effects, Oman Medical Journal, 25(1): 17–21.

Kariyawasam, S., Bandara, N., Koralagama, A., Senanayake, S. 2004, Challenging Epilepsy with Antiepileptic Pharmacotherapy in a Tertiary Teaching Hospital in Sri Lanka, Neurology India 52(2): 233 (2004).

Liu, J., Zhiliang, L., Hu.D. dan Xiaohong, Y., 2013, Adherence to Treatment and Influencing Factors in a Sample of Chinese Epilepsy Patients, Epileptic Disord, 15(5): 94-289.

Lo, T.O., 2003, Adherance to Long – Term Therapies, World Health Organization, Genewa

Martins. H.H, Alonso, N.B., Vidal-Dourado, M., et al, 2011, Are adverse effects of Antiepileptic Drugs Different in Symptomatic Partial and idiopathic Generalized Epilepsies? The Portuguese–Brazilian validation of the Liverpool Adverse Events Profile, Epilepsy Behav. 22(3): 511–517

Mustarsid., Nur, F.T., Setiawati, S.R. dan Salimo, H., 2011, Pengaruh Obat Antiepilepsi Terhadap Gangguan Daya Ingat, Sari Pediatri, 12(5):302-306

Shamaa, E.T., dan Mahmoud, D.A., 2013, Factors Contributing To Therapeutic Compliance of Epileptic Patients And The Suggestive Solutions, Journal of Biology, Agriculture and Healthcare, 3(2): 209-222

Setiaji, A., Tun, P., Saraharto., Amalia, N. dan Setyawati, 2014, Pengaruh Penyuluhan Tentang Penyakit Epilepsi Anak Terhadap Pengetahuan Masyarakat Umum, Media Medika Muda, 1: 5 - 6.

Sirven, J., Fife, D.T., 2005, Antiepileptic Drug and Their Impact on Balance, Future Medicine, 147-155

Stefan, H., G, Michelson., C, Tilz. dan A, Juneman, 2007, Visual Field Defect during Therapy with Valproic-Acid, Europan Journal Of Neurology, 14: 32-929.

Vasquez, B., 2004, Monotherapy in Epilepsy, Arch Neurol, 62: 1361- 1365

Wieshmann, U.C., and Baker.G., 2016, Efficacy and Tolerability of Anti-Epileptic Drugs – an Internet Study, Acta Neurol, 35(5) : 533–539.

Wiffen, P., Marc, M., Melanie, S. dan Nicola, S, 2010, Farmasi Klinis Oxford, Penerbit Buku Kedokteran EGC, Jakarta.

DOI: https://doi.org/10.22146/jmpf.70942

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